Human strongyloidiasis is a chronic parasitic disease caused by infection with Strongyloides stercoralis, a soil-transmitted helminth that is estimated to infect 300–600 million people worldwide. This neglected tropical disease (NTD) is endemic globally, predominately in the South-East Asia, Afric...an and Western Pacific regions, and in South and Central America. Strongyloidiasis has a wide range of clinical presentations, including subclinical disease, symptomatic disease (often with diarrhoea, abdominal pain and urticaria) and a rare but deadly complication of hyperinfection with disseminated disease. The feared complication of disseminated strongyloidiasis can occur in the setting of immunocompromising conditions (e.g. human T-cell lymphotropic virus type 1 infection and malignancies) or immunosuppressive medications (e.g. steroids) and has an estimated case-fatality rate exceeding 60%. The standard treatment for chronic S. stercoralis infection is oral medication with ivermectin.
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The present guidelines incorporate all these changes, leading to a substantial reconfiguration of therapeutic choices for both disease forms.
HAT is a serious, life-threatening disease and the efficacy of fexinidazole depends on swallowing the medicine after an appropriate intake of food as well as... on completing the full 10-day treatment schedule. Therefore, the recommendations regarding fexinidazole administration are considered key elements that must be carefully followed. When the conditions listed in these guidelines are not met for any individual patient, the alternative available treatments should be prescribed.
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English and French.
WEEKLY EPIDEMIOLOGICAL RECORD, NO 37, 13 SEPTEMBER 2024, 505-524
Schistosome snail resource (SSR) is Wellcome Trust funded, open access biomedical resource that aims to generate and make freely available live schistosome life-cycle stages, snail intermediate hosts and related material for schistosomiasis research.
The Lancet Volume 403, Issue 10422p203-218January 13, 2024, Free Download with free registration
The consortium is an international public-private partnership that aims to reduce the global disease burden of schistosomiasis by addressing the medical needs of infected children between the ages of 3 months and 6 years. By doing so, we hope to contribute to the ongoing efforts to eliminate schisto...somiasis and improve child health.
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Human African trypanosomiasis (HAT), or sleeping sickness, is caused by trypanosome parasites that are transmitted by tsetse flies. HAT is found only in sub-Saharan Africa. Two subspecies of Trypanosoma brucei cause disease: T. b. gambiense in West and Central Africa, and T. b. rhodesiense in East A...frica.
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The Lancet Regional Health - Americas 2024;37: 100881
Published Online 13 September 2024 https://doi.org/10.1016/j.lana.2024. 100881
Global Health Observatory (GHO) interactive graph
MEDBOX Issue Brief no.35: The first issue brief on the NTD Toolbox contains general strategies, roadmaps, key treatment guidelines, reports, and training material on Buruli ulcer, Chagas, and Leishmaniasis.
Chagas disease is caused by Trypanosoma cruzi. Infection is transmitted to humans when bitten by Triatominae (reduviid, kissing, or assassin) bugs in South and Central America, Mexico, and very rarely in the US. Less commonly, T. cruzi is transmitted via ingestion of sugar cane juice or food contami...nated with infected Triatominae bugs or their feces, transplacentally from an infected mother to her fetus, or via blood transfusion or an organ transplant from an infected donor.
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Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021–2030 (“the road map”) sets explicit targets for the elimination of onchocerciasis by 2030, including eliminating the need for mass drug administration (MDA) of ivermectin in at least... one focus in 34 countries, in more than 50% of the population in at least 16 countries, and in the entire endemic population in at least 12 countries. The road map also targets interruption of onchocercal transmission in 12 countries by 2030. Achieving these targets and milestones will require a number of critical actions. These include establishing a well-coordinated global partnership to connect stakeholders and existing partnerships at all levels in order to improve coordination and collaboration, accelerate technical progress, implement a harmonized research agenda and enhance service delivery.
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Three full years have passed since the launch of the road
map for neglected tropical diseases 2021–2030. Data on
progress begin to provide insights into the prospects of
attaining the 2030 targets.
No vaccines or drugs to prevent infection are available. The best way for travelers to prevent infection is to protect themselves from sand fly bites. To decrease the risk of being bitten, follow these preventive measures:
Avoid outdoor activities, especially from dusk to dawn, when sand flies ge...nerally are the most active.
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This document is the second in a series of global reports describing progress towards the 2030 targets set in Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021–2030. It describes a wide range of activities, accomplishments and challenge...s across the portfolio of NTDs and across all six WHO regions. The report presents epidemiological and programmatic data for 2022, which were gathered, compiled and analysed in 2023. In some cases, 2023 data are available and presented; in other cases, less recent information is included, when 2022 data are not available. In addition, it presents the main facts or events that occurred in 2023.
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This toolkit is a comprehensive set of practical tools and resources designed to support country-level risk communication and community engagement (RCCE) practitioners, decision-makers, and partners to plan and implement readiness and response activities for dengue fever outbreaks. The toolkit conta...ins: information about dengue fever; RCCE considerations for how to approach key issues during dengue fever outbreaks; tools for understanding the context in which dengue fever outbreaks occur; methods for collecting data to inform strategy development and bring evidence into planning and implementation of activities; guidance to support vector control and prevention activities; case studies; and links to existing RCCE tools and training. It is one of a suite of toolkits on RCCE readiness and response to a range of disease and response areas.
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For communities already burdened by poverty and ravaged by scourges such as malaria and tuberculosis, the parasitic disease schistosomiasis is especially devastating. The disease weakens the body's resistance to other infections and leads to poor growth and impaired learning in children. The Carter ...Center works to control the disease and provide hope for future generations in Nigeria, the most schistosomiasis-endemic country in Africa.
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Trop. Med. Infect. Dis. 2024, 9(9), 222; https://doi.org/10.3390/tropicalmed9090222
