Chagas disease, also known as American trypanosomiasis, is a potentially life-threatening illness caused by the protozoan parasite Trypanosoma cruzi. About 6–7 million people worldwide are estimated to be infected with T. cruzi. The disease is found mainly in endemic areas of 21 continental Lati...n American countries, where it has been mostly transmitted to humans and other mammals by contact with faeces or urine of triatomine bugs (vector-borne), known as kissing bugs, among many other popular names, depending on the geographical area.
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La enfermedad de Chagas es parasitaria y afecta a más de 6 millones
de personas en el mundo. Como normalmente es asintomática durante
años, los nuevos casos suelen no detectarse ni reportarse y la mayoría
de las personas con la enfermedad no tiene conciencia de su condición.
Se diagnostica ...a menos del 10% de las personas afectadas, y en su gran
mayoría estas no reciben el tratamiento que necesitan. Sin tratamiento,
la enfermedad de Chagas puede causar daños irreversibles al corazón y
otros órganos vitales, o la muerte.
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Lesson on schistosomiasis (bilharziasis): Causes, Symptoms and Treatment. Schistosomiasis is caused by parasitic blood flukes from the genus schistosoma. Schistosoma cercariae penetrate human skin and enter the bloodstream of the infected individual, where the parasites enter the portal vein. Schist...osoma parasites also enter the mesenteric and bladder circulations, where they release eggs. Symptoms of schistosomiasis are related to the location of the parasites, the parasite burden and the amount of eggs produced. Systems affected in schistosomiasis include the hepatic, splenic, genitourinary, pulmonary, and nervous systems.
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DNA studies of Egyptian mummies shows evidence of the existence of Schistosomiasis about 5000 years ago. Schistosomiasis is increasing in prevalence, affecting nearly 10% of the world’s population and ranking second only to malaria as a cause of morbidity & mortality.
Schistosoma haematobium are... found in tropical Africa & part of southwest Asia.
Schistosoma mansoni are found in tropical Africa, part of southwest Asia, south America & Caribbean islands.
Schistosoma japonicum are found in parts of Japan, China, Philippines, India & part of southeast Asia.
Blood flukes are known as schistosomes because of the "split body" on the ventral side of the male, in which the female is held during insemination and egg laying.
Man is the definite host harbouring adult parasites, and fresh water snails are intermediate hosts.
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Schistosomiasis is the medical term for Bilharzia.
Bilharzia is an acute and chronic disease caused by schistosome parasitic worms.
You cannot see the parasite when it enters your body.
The worms can stay in the body from 5 to 30 years.
At least 261 million people required.
Species of the genus Schistosoma are digenetic trematodes and the causative agents of the Neglected Tropical Disease (NTD) schistosomiasis; a parasitic disease that ranks second only to malaria in terms of socioeconomic impacts. Over 220 million people worldwide are currently infected, 90% of whom l...ive in sub-Saharan Africa (SSA), with an estimated annual mortality of at least 200,000. Infection in humans, as well as alternative mammalian definitive hosts, occurs in contaminated freshwater environments via cercariae shed from specific snail intermediate hosts. Early acute morbidity can occur following cutaneous penetration, sometimes leading to an urticarial rash known as swimmers itch or cercarial dermatitis.
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Schistosomiasis, also known as Bilharzia, is an infection caused by a parasitic worm that lives in fresh water in subtropical and tropical regions. Schistosomiasis is second only to malaria as the most devastating parasitic disease. The parasites that cause schistosomiasis live in certain types of f...reshwater snails. The infectious form, known as cercariae, emerge from the snail and then contaminate the water. People become infected when their skin comes into contact with the contaminated freshwater. Most human infections are caused by Schistosoma mansoni, Schistosoma haematobium, or Schistosoma japonicum.
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Schistosomiasis, also known as bilharzia, is an infection caused by a parasitic worm that lives in fresh water in subtropical and tropical regions.
Schistosomiasis is a chronic parasitic infection caused by worms. It is most common in rural and impoverished populations. In the Americas, the parasite species is Schistosoma mansoni, which is associated with intestinal schistosomiasis. The main risk factor for infection is exposure through househo...ld, work, or recreational activities in fresh water contaminated with faeces from infected humans.
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Schistosomiasis is an acute and chronic parasitic disease caused by blood flukes (trematode worms) of the genus Schistosoma. Estimates show that at least 251.4 million people required preventive treatment in 2021. Preventive treatment, which should be repeated over a number of years, will reduce and... prevent morbidity. Schistosomiasis transmission has been reported from 78 countries. However, preventive chemotherapy for schistosomiasis, where people and communities are targeted for large-scale treatment, is only required in 51 endemic countries with moderate-to-high transmission.
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Schistosomiases are acute or chronic visceral parasitic diseases due to 5 species of trematodes (schistosomes). The three main species infecting humans are Schistosoma haematobium, Schistosoma mansoni and Schistosoma japonicum. Schistosoma mekongi and Schistosoma intercalatum have a more limited dis...tribution.
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Full Perscribing information on Fexinidazole Tablet for oral use
INDICATIONS AND USAGE
Fexinidazole Tablets are indicated for the treatment of both the first-stage (hemolymphatic) and second-stage (meningoencephalitic) human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense in pati...ents 6 years of age and older and weighing at least 20 kg.
Limitations of Use
Due to the decreased efficacy observed in patients with severe second stage HAT (cerebrospinal fluid white blood cell count (CSF-WBC) >100 cells/μL) due to T. brucei gambiense disease, Fexinidazole Tablets should only be used in these patients if there are no other available treatment options [see Warnings and Precautions (5.1)]
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In support of the London Declaration goals, PATH aims to catalyze engagement of the diagnostics industry and product development efforts. As part of this work, PATH conducted a diagnostic landscape analysis to identify gaps and evaluated current and nascent HAT diagnostics that may provide solutions....
We conducted literature reviews and interviews with key stakeholders to identify use cases for HAT diagnostics, understand current practices, and analyze progress toward more robust diagnostics across
different biomarkers.
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Un comité OMS d’experts sur la trypanosomiase humaine africaine (THA) : lutte et surveillance, s’est réuni à Genève (Suisse), du 22 au 26 avril 2013. Le Dr H. Nakatani, sous-directeur général pour le VIH/SIDA, la tuberculose, le paludisme et les maladies tropicales négligées, a ouvert la... réunion au nom du Dr M. Chan, directeur-général de l’OMS.
La THA est une maladie qui afflige les populations rurales de l’Afrique, là où prolifère la mouche tsé-tsé (ou glossine), vecteur des trypanosomes qui en sont la cause. On distingue deux formes de THA : la forme à T. b. gambiense ou forme gambienne, endémique en Afrique de l’Ouest et en Afrique centrale et qui
représente actuellement 95 % des cas, et la forme à T. b. rhodesiense ou forme rhodésienne, endémique en Afrique de l’Est et en Afrique australe, à laquelle sont dus les 5 % restants.
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People with Guinea worm disease (GWD) have no symptoms for about 1 year. Then, the person begins to feel ill. Symptoms can include the following:
Slight fever
Itchy rash
Nausea
Vomiting
Diarrhea
Dizziness
A blister then develops. This blister can form anywhere on the skin. However, the blis...ter forms on the lower body parts in 80%–90% of cases. This blister gets bigger over several days and causes a burning pain. The blister eventually ruptures, exposing the worm. The infected person may put the affected body part in cool water to ease the symptoms or may enter water to perform daily tasks, such as fetching drinking water. On contact with water, the worm discharges hundreds of thousands of larvae into the water.
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Today is World Chagas Disease Day. This year’s theme is Finding and reporting every case to defeat Chagas disease.
Despite progress, the global case detection rate for Chagas disease is low (estimated to be around 10%), posing a substantial barrier to accessing treatment and care and in prevent...ing transmission.
Often termed as a “silent and silenced disease”, many people with Trypanosoma cruzi infection (the parasite that causes the disease) develop no symptoms or unspecific mild symptoms. Moreover, many countries with cases lack systems to track the number of affected people and active transmission routes.
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Datos y cifras
Se calcula que en el mundo hay entre 6 y 7 millones de personas infectadas por el Trypanosoma cruzi, el parásito causante de la enfermedad de Chagas, la mayoría de ellas en América Latina.
La infección por Trypanosoma cruzi se puede curar si el tratamiento se administra al poco ...tiempo de producirse la infección.
Hasta un 30% de los enfermos crónicos presentan alteraciones cardíacas y hasta un 10% padecen alteraciones digestivas, neurológicas o combinadas que pueden requerir un tratamiento específico.
El control de vectores y otras estrategias destinadas a reducir la transmisión que estos producen son los métodos más útiles para prevenir la enfermedad de Chagas en América Latina.
Los análisis de sangre son fundamentales para prevenir la infección por transfusiones o trasplantes de órganos en todo el mundo.
La detección y el tratamiento de niñas infectadas y mujeres infectadas en edad fértil es clave, además del cribado de los recién nacidos y otros hijos de madres infectadas que no hayan recibido antes tratamiento antiparasitario.
La enfermedad de Chagas, también llamada tripanosomiasis americana, es una enfermedad potencialmente mortal causada por el parásito protozoo Trypanosoma cruzi (T. cruzi).
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Principaux faits
D’après les estimations, 6 à 7 millions de personnes dans le monde sont infectées par Trypanosoma cruzi (T. Cruzi), le parasite responsable de la maladie de Chagas. La plupart de ces personnes vivent en Amérique latine.
La transmission à l’être humain se fait principalem...ent, en Amérique latine, par l’intermédiaire d’un insecte appelé triatome, qui peut être porteur de T. cruzi.
Parmi les autres modes de transmission de la maladie de Chagas, figurent : la transmission orale (par voie alimentaire), la transfusion de sang ou de produits sanguins, la transmission mère-enfant (congénitale), la transplantation d’organes et les accidents de laboratoire.
La maladie de Chagas ne touchait auparavant que des zones rurales de la Région des Amériques, et surtout de l’Amérique latine. Ces dernières décennies, toutefois, les mouvements de population ont fait que la plupart des personnes infectées sont des habitants de zones urbaines (urbanisation) et que la maladie s’est propagée à d’autres continents (où T. cruzi se transmet par des voies non vectorielles).
L’infection à T. cruzi est curable si un traitement est instauré rapidement après l’infection.
Chez les personnes infectées de façon chronique, un traitement antiparasitaire peut éventuellement prévenir ou enrayer la progression de la maladie, et éviter sa transmission, notamment de la mère à l’enfant.
Jusqu’à 30 % des personnes infectées de façon chronique présentent des troubles cardiaques, et jusqu’à 10 % d’entre elles souffrent de troubles digestifs et/ou neurologiques, ce qui peut imposer un traitement particulier.
Les principales méthodes de prévention de la maladie de Chagas en Amérique latine sont la lutte antivectorielle ainsi que d’autres stratégies visant à réduire la transmission vectorielle.
Dans le monde entier, le dépistage sanguin joue un rôle crucial dans la prévention de l’infection par transfusion ou transplantation d’organes.
Il est essentiel de détecter et de traiter l’infection chez les femmes et les filles en âge de procréer, ainsi que de soumettre tout nouveau-né et ses frères et sœurs à un dépistage dans le cas où la mère est infectée et n’a jamais reçu de traitement antiparasitaire.
Certains facteurs socio-économiques et environnementaux influent fortement sur la maladie de Chagas, dont la propagation et les différentes dimensions interdépendantes justifient la nécessité de mettre en œuvre des stratégies de lutte multisectorielles.
Quelques pays ont mis en place la notification et la surveillance des cas aigus et chroniques et des voies de transmission actives, qui sont essentielles à la lutte contre la maladie de Chagas.
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Болезнь Шагаса, известная также как американский трипаносомоз, — потенциально опасное для жизни заболевание, вызываемое простейшим паразитом Trypanosoma cruzi.
إن داء شاغاس المعروف أيضا باسم داء المثقبيات الأمريكي، مرض قد يكون مهدداً للحياة يسببه الطفيلي الأوّالي المعروف باسم المِثْقَبِيَّة الكروزيَّة.