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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Policy brief on tuberculosis-associated disability

World Health Organization WHO (2023) C_WHO

People affected by impairments and disabilities associated with TB are even more likely to belong to marginalized segments of society and are more likely to have their human rights unprotected. The challenges faced by people affected by TB include the consequences of impairment and disability associ... more

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Africa, WASH, and the Millennium Development Goals: A Local Systems Case Study of How Senegal Achieved MDG Target 7c

McGahey, Christopher USAID (2017) C1

Nationally, Senegal met the MDG target for water supply access. It did this by engaging the public and private sectors to effectively invest and report on investments. It focused on larger population centers, less on remote regions of the country. Its achievements set the stage for more equitable an... more

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National Community Health Worker Strategy in Zambia

Ministry of Health, Zambia (2010) C1

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Provincial Guide to Cultural and Religious Practices and Observances in Managing COVID-19 Fatalities in the Western Cape

Western Cape Government, South Africa (2020) CC

External Link

Kenya Comprehensive Refugee Programme 2015

UN High Commissioner for Refugees (2015)

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Handbook for Emergencies

UNHCR (2007) C2

Section One summarizes UNHCR’s mandate of international protecdtion and the aim and principles of emergency response; Section Two deals with emergency management; Section Three covers the vital sectors and problem areas in refugee emergencies, including health, food, sanitation and water, a... more

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Terminology and Information on Drugs

United Nations Office on Drugs and Crime UNODC United Nations (2016) CC

Third edition

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“As if We Weren’t Human” -Discrimination and Violence against Women with Disabilities in Northern Uganda

Human Rights Watch (2010) C1

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Malawi: 2019 Flood Response Plan and Appeal

Government of Malawi (2019) C2

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European nurse: Information and communication guide on microbes

European specialist nurse organisation (ESN) (2020) C2

This manual addresses all the issues. It focus on the cycle of microbes, antibiotics, vaccination, AMR, infection prevention and control. It will support nurses on better action and also on communication towards their patients and families.

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Safety surveillance of COVID-19 vaccines in pregnant and breastfeeding women

World Health Organization WHO (2021) C_WHO

COVID-19 Vaccines: 1 Safety Surveillance 2 Manual While there is no indication that pregnant women have an increased susceptibility to infection with SARS-CoV-2, there is evidence that pregnancy may increase the risk of severe illness and mortality from COVID-19 disease in comparison with non-pregn... more

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National Comprehensive HIV Prevention, Care, and Treatment Training for Pharmacy Professionals. Participant Manual

Ministry of Health, Federal Democratic Republic of Ethiopia Ministry of Health, Federal Democratic Republic of Ethiopia (2018) CC

In line with its decentralization principle, the Ethiopian Health Policy has achieved great progress in improving access to comprehensive HIV/AIDS services to the majority of the population. Both quality and coverage of services have improved significantlysince the initiation... more

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Crisis and Emergency Risk Communication Quick Guide

Centers for Disease Control and Prevention (2008) C_CDC

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WHEELCHAIR SERVICE TRAINING PACKAGE - For Managers (Reference Manual and Workbook)

Sarah Frost, Chapal Khasnabis, Kylie Mines, and Lourdes de la Peza WHO (2015) C_WHO

WHO published and launched the third part of the Wheelchair Service Training Package (WSTP) series consisting of two sub-packages: the Wheelchair Service Training Package for Managers (WSTPm) and the Wheelchair Service Training Package for Stakeholders (WSTPs). WHO recognises that in order to develo... more

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Discrimination and Barriers Facing Women and Girls with Disabilities in Afghanistan

Human Rights Watch (2020) C2

Afghanistan has one of the largest populations per capita of persons with disabilities in the world. At least one in five Afghan households includes an adult or child with a serious physical, sensory, intellectual, or psychosocial disability. More than 40 years of war have left more than one million... more

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Policy brief: Access to assistive technology

World Health Organization WHO (2021) C_WHO

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Guidelines for long-lasting insecticidal nets care, repurposing and disposal

Ministry of Health Uganda, WHO Uganda WHO Regional Office for Africa (2019) C_WHO

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The Climate Dictionary - Speak Climate Fluently

United Nations Development Programme (2023) CC

The Climate Dictionary is an initiative aimed at providing an everyday guide to understanding climate change. It seeks to bridge the gap between complex scientific jargon and the general public, making climate concepts accessible and relatable to individuals from various backgrounds and levels of ex... more

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Falling short

International Union Against Tuberculosis and Lung Disease; Treatment Action Group; msh; ec al. (2017)

Ensuring Access to Simple, Safe and Effective First-Line Medicines for Tuberculosis. Accessed in November 2017.