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Cryptococcal disease, particularly cryptococcal meningitis is a significant cause of morbidity and mortality among people living with HIV with advanced HIV disease. It is estimated that it is responsible for nearly 19% of AIDS-related mortality, second only to tuberculosis. Rapid screening, diagnosi ... more
An overview of validation structures and responsibilities at national, regional and global levels. This governance document supplements the global guidance document. Validation of elimination requires rigorous assessment at the national, regional and global levels of the impact and process indicato ... more
In: Antenatal Care, Maternal Care, Under 5 Clinics, Family Planning Clinics and HIV Exposed Child Follow Up. This 5th Edition of the Malawi Guidelines for Clinical Management of HIV in Children and Adults is implemented from January 2022. It replaces all previous editions of the Malawi Antiretrovir ... more
Essential triple EMTCT services include testing for HIV, syphilis and HBV in ante- natal care (ANC) settings; prompt and efficacious interventions to treat women who test positive; prevent transmission of any of the infections to their children; counseling for women and their partners to reduce t ... more
Pathogens 2022, 11, 33. https://doi.org/10.3390/pathogens11010033
Journal of Adolescent Health 2022 1-16
Front Psychiatry. 2022 Aug 11;13:937723. doi: 10.3389/fpsyt.2022.937723. PMID: 36061286; PMCID: PMC9429610. The review findings show that there exist several diverse interventions that promote mental health among adolescents in sub-Saharan Africa. These interventions can be implemented in diverse se ... more
J Int AIDS Soc. 2022 Nov;25(11):e25970. doi: 10.1002/jia2.25970. PMID: 36377082; PMCID: PMC9663860. These reassuring findings suggest that dolutegravir and raltegravir are effective and safe as preferred regimens in children and adolescents living with HIV. With the rollout of dolutegravir in paedia ... more
A Guide for Community Case Workers in OVC Programs. This guide is meant to help you, a community case worker or facility case manager working on an orphans and vulnerable children (OVC) program, to understand your role in supporting multi-month dispensing (MMD) of anti-retroviral (ARV) medicines f ... more
These guidelines provide new and updated recommendations on the use of point-of-care testing in children under 18 months of age and point-of-care tests to monitor treatment in people living with HIV; the treatment monitoring algorithm; and timing of antiretroviral therapy (ART) among people living w ... more
These guidelines provide new and updated recommendations on the use of point-of-care testing in children under 18 months of age and point-of-care tests to monitor treatment in people living with HIV; the treatment monitoring algorithm; and timing of antiretroviral therapy (ART) among people living w ... more
Validation of elimination of mother-to-child transmission, or vertical transmission, of HIV, syphilis and hepatitis B virus (HBV), is an attestation that a country has successfully met standard criteria for elimination, or for being at 1 of the 3 levels of achievement on the ‘Path to Elimination ... more
Front. Cell. Infect. Microbiol., 12 April 2021 Sec. Parasite and Host Volume 11 - 2021 | https://doi.org/10.3389/fcimb.2021.656938 Over the past several decades, malaria/HIV-1 co-infection has become a significant global public health problem in co-endemic areas of the world.
Bhana A et al. Journal of the International AIDS Society 2021, 24(S2):e25713
Multi-month dispensing (MMD) is the prescribing and dispensing of three to six months of antiretrovirals (ARV) and other medicines required for treatment of people living with HIV (PLHIV). This approach is in contrast to the current standard of care approach where drug dispensing requires monthly ... more

Prevention of mother-to-child transmission of HIV

Le Saout, E. International MSF HIV working Group (2020) C2
Internal Document
Prevention of mother-to-child HIV transmission (PMTCT) has been a success in many respects but there is still much to do to eliminate mother-to child transmission (MTCT), particularly in low antiretroviral therapy (ART) coverage areas and in the postnatal phase. The success of PMTCT is highly dep ... more
Technical Document
What works?
Currently, there are only two manufacturers with HIV POC diagnostic products prequalified by the World Health Organization (WHO) and eligible for procurement through the United Nations. UNICEF concluded its last tender for HIV EID and VL POC diagnostic technologies in 2018 and awarded two manufact ... more