In the 126 years since it was first described, scientists have learned a great deal about Buruli ulcer, (an ulcerating skin infection caused by the environmental bacterium, Mycobacterium ulcerans), including how to treat it. Yet, there is 1 question about this neglected tropical disease that has rem...ained unanswered: how is M. ulcerans transmitted to humans? In southeastern Australia, where Buruli ulcer is endemic and cases are increasing, researchers are putting together the M. ulcerans transmission puzzle. The more they learn, the better equipped they will be for managing infections.
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The Lancet Volume 399, Issue 10327p786-797February 26, 2022
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Journal of Computational Biophysics and ChemistryVol. 22, No. 01, pp. 31-41 (2023)
Buruli ulcer (BU), a neglected tropical disease (NTD), is an infection of the skin and subcutaneous tissue caused by Mycobacterium ulcerans. The disease has been documented in many South American, Asian, and Western Pacific countries and is widespread throughout much of Africa, especially in West... and Central Africa.
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Status of endemicity of Buruli ulcer 2023
Although Buruli ulcer, tuberculosis, and leprosy are the three most common mycobacterial diseases, One Health dimensions of these infections remain poorly understood. This narrative review aims at exploring the scientific literature with respect to the presence of animal reservoir(s) and other envir...onmental sources for the pathogens of these infections, their role in transmission to humans and the research on/practical implementation of One Health relevant control efforts.
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Buruli ulcer (BU), the second most common mycobacterial disease in West Africa, is a necrotizing skin disease that can lead to high morbidity in affected patients. The disease is caused by Mycobacterium ulcerans (MU), whose major virulence factor is mycolactone. Although early infection can be treat...ed with antibiotics, an effective preventative strategy is challenging due to unknown reservoir(s) and unresolved mode(s) of transmission.
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Information sheet Buruli Ulcer
PLoS Negl Trop Dis 16(11): e0010908. https://doi.org/10.1371/journal.pntd.0010908
Diagnostics 2019, 9(4), 204; https://doi.org/10.3390/diagnostics9040204
The aim of the meeting was to broaden the network’s initiatives. Preliminary work involved integrating laboratory testing for skin NTDs other than Buruli ulcer, such as cutaneous leishmaniasis, mycetoma, leprosy and yaws, while extending the network’s reach to encompass additional laboratories.
This is a series of videos about Buruli ulcer disease from Kwame Nkrumah University of Science and Technology. These videos were created Richard Phillips, Stephen Sarfo, Emmanuel Adu, Veronica Owusu-Afriyie, and Cary Engleberg (University of Michigan). The complete learning module is available throu...gh the African Health OER Network at: http://open.umich.edu/education/med/oernetwork/med/internal/buruli-ulcer/2009.
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Buruli Ulcer, buruli ulcer signs and symptoms, buruli ulcer treatment, Buruli ulcer risks, Buruli ulcer disease, health care workers and buruli ulcer
Technical Update
Areas of Africa endemic for Buruli ulcer (BU), caused by Mycobacterium ulcerans, also have a high prevalence of human immunodeficiency virus (HIV), with adult prevalence rates between 1% and 5% (Maps). However, there is limited information on the prevalence of BU–HIV coinfection.... Preliminary
evidence suggests that HIV infection may increase the risk of BU disease (1–3). In the Médecins Sans Frontières project in Akonolinga, Cameroon, HIV prevalence was approximately 3–6 times higher among BU patients than the regional estimated HIV prevalence (2). Similarly in Benin and Ghana, BU
patients were 8 times and 3 times respectively more likely to have HIV infection than those without BU (1, 3). Further study is needed to clarify this association and enhance knowledge about the prevalence ofBU–HIV coinfection in endemic areas.
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Website last accessed on 18.03.2023
Principaux faits
L’ulcère de Buruli est une infection chronique débilitante causée par la bactérie Mycobacterium ulcerans.
L’ulcère de Buruli a été signalé dans au moins 33 pays situés dans des régions au climat tropical, subtropical ou tempéré d’Afrique, d’Amérique ...du Sud et du Pacifique occidental.
Cette infection affecte la peau et parfois les os et peut entraîner des déformations et des incapacités permanentes.
Le mode de transmission de cette maladie est inconnu, on ne peut la prévenir.
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The guide contains valuable tools for wound care and the rehabilitation of people affected by Buruli ulcer. It is also helpful for peripheral health centres in areas where Buruli ulcer is endemic and to people and their families affected by the disease