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Chagas disease, also known as American trypanosomiasis, is a potentially life-threatening illness caused by the protozoan parasite Trypanosoma cruzi. About 6–7 million people worldwide are estimated to be infected with T. cruzi. The disease is found mainly in endemic areas of 21 continental Lati
...
n American countries, where it has been mostly transmitted to humans and other mammals by contact with faeces or urine of triatomine bugs (vector-borne), known as kissing bugs, among many other popular names, depending on the geographical area.
more
Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 117: e200460, 2022
Integrating the multiple dimensions of the problem into a coherent approach adapted to field realities and needs represents an immense challenge, but the payoff is more effective and sustainable experiences, with higher social awareness
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, increased case detection and follow-up, improved adherence to care, and integrated participation of various actors from multiple action levels. Information, Education, and Communication (IEC) initiatives have great potential for impact in the implementation of multidimensional programs of prevention and control successfully customised to the diverse and complex contexts where Chagas disease persists.
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The Chagas disease data platform is founded upon a collaborative framework that aims to bring together partners including individual researchers in Chagas endemic regions, leading global research institutions, policy specialists and funders from across the globe. The theme is coordinated by a team b
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ased at IDDO and at the Drugs for Neglected Diseases initiative’s Latin America Office.
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Chagas disease, which is caused by infection with the parasite Trypanosoma cruzi, is known as the silent disease. An estimated 8 million people have the disease and most of them do not know that they are infected.
La dengue est une maladie virale transmise par les moustiques qui s’est rapidement propagée dans toutes les Régions de l’OMS ces dernières années. Le virus de la dengue est transmis par des moustiques femelles, principalement de l’espèce Aedes aegypti, mais aussi dans une moindre mesure A
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e. albopictus. Ces moustiques sont aussi vecteurs du virus du chikungunya, du virus amaril et du virus Zika. La dengue est largement répandue sous les tropiques, avec des variations locales du risque qui dépendent des caractéristiques climatiques, ainsi que de facteurs sociaux et environnementaux.
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El dengue es una enfermedad vírica transmitida por mosquitos que en los últimos años se ha propagado rápidamente a todas las regiones de la OMS. El virus del dengue se transmite a través de mosquitos hembra principalmente de la especie Aedes aegypti y, en menor grado, de la especie Ae. albopict
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us. Estos mosquitos también son vectores de los virus de la fiebre chikungunya, la fiebre amarilla y el Zika. La enfermedad está muy extendida en los trópicos, con variaciones locales en el riesgo que dependen de los parámetros climáticos y de los factores sociales y ambientales.
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Causada por el parásito Trypanosoma cruzi, la enfermedad de Chagas es una enfermedad silenciosa. Se estima que 8 millones de personas son portadoras y la mayoría no lo sabe.
This is a tool meant to share and train the healthcare workers with precise and updated information about Chagas disease, in order to increase the amount of diagnostics and treatments amongst the affected people.
Chagas Coalition Resource Platform
recommended
Global chagas coalitions members contributions
Chagas disease is named after the Brazilian physician Carlos Chagas, who discovered the disease in 1909. It is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors and is found only in the Americas (mainly, in rural areas of Latin America where pover
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ty is widespread). Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis
more
L’objectif de ces lignes directrices est de présenter l’ensemble complet des recommandations et des énoncés de meilleures pratiques de l’OMS en matière d’avortement
Comparison of the Influence of Different Nucleic Acid Extraction Assays on the Sensitivity of Trypanosoma cruzi-Specific Real-Time PCR
Kann, S.; Zabala-Monterroza, W.; García, C.
Multidisciplinary Digital Publishing Institute MDPI
(2022)
CC
For the molecular diagnosis of Chagas disease by real-time PCR (polymerase chain reaction), optimization of diagnostic accuracy is desirable. The detection limit of real-time PCR assays for the diagnosis of Trypanosoma cruzi in human serum is affected by various influences including the choice of th
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e nucleic acid extraction assay. In this study, three nucleic acid extraction assays were compared regarding their influence on the sensitivity of a T. cruzi-specific real-time PCR with 62 reference sera containing T. cruzi target DNA (deoxyribonucleotide acid). More than 95% of the positive sera were correctly identified after all three nucleic acid extraction strategies with a detection rate ranging from 96.8% (60/62) for the worst assay to 100% (62/62) for the best one. A matched pairs analysis for the comparison of the cycle threshold (Ct) values obtained with the 59 reference samples with positive real-time PCR results after all three nucleic acid extraction schemes indicated differences in a range of about 3 Ct steps. Summarized, all three compared nucleic acid extraction schemes were basically suitable for T. cruzi-specific PCR from serum with some minor differences. However, in the case of low quantities of circulating parasite DNA in the serum of a patient with Chagas disease, even minor effects can make a difference in the individual diagnosis.
more
To support its R&D activities on Chagas disease, DNDi launched the Chagas Clinical Research Platform (CCRP). The platform brings together partners, experts, and stakeholders to provide support for evaluation and development of new treatments for Chagas disease. The patient-centred platform aims to f
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acilitate clinical research, provide a forum for technical discussions, develop a critical mass of expertise, and strengthen institutional research capacities. In addition, it identifies and reviews priority needs, works towards standardization of methodology to assess drug efficacy and reviews alternatives for using current approved drugs (new schemes, doses, combination) and special scenarios (resistance).
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Die Infektion wird durch nachtaktive, blutsaugende Raubwanzen übertragen. Während des Blutsaugens scheiden die infizierten Wanzen Trypanosomen aus, die Bindehaut, Schleimhäute, Abschürfungen und Hautverletzungen einschließlich der Bißwunde kontaminieren können. Die Übertragung kann auch durc
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h Bluttransfusion erfolgen, wenn das Blut von einem infizierten Spender stammt. Auch kongenitale Infektionen, verursacht durch Parasiten, die während der Schwangerschaft die Plazenta passieren, sind möglich. Der Erreger, Trypanosoma cruzi, infiziert viele Spezies.
more
Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 117: e220083chgsa, 2022
Two adjectives raise an issue for communicators working on Chagas disease (CD): “invisible and silent”. Two adjectives that can be ascribed to other neglected tropical diseases (NTD), but which are part of the essence of CD. Br
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inging CD out of its situation of neglect and oblivion is a mission entrusted mainly to the world of communication as well as of science, politics and financial resources. However, communication has not always been considered among the priorities in the approach to the disease, except in valuable exceptions, some of which we have seen in the preceding article.
more
Chagas disease is a neglected tropical disease cause by the Trypanosoma cruzi parasite. It is spread mostly by insects known as Triatominae, or kissing bugs.
If left untreated, Chagas can cause serious problems to the heart and digestive system.
About six to seven million people worldwide, mostly in Latin America, are estimated to be infected with
Trypanosoma cruzi, the parasite that causes Chagas disease (WHO data from 2021). Chagas disease is
found mainly in endemic areas of 21 Latin American countries.
Info Chagas
What do we need to know abaout Chagas Disease? What is Chagas Disease?
How Chagas disease is transmitted video.
Video available with spanish sub title
The BeatChagas platform is a tool developed by the Technical Group of Information, Education, and Communication (IEC) for Chagas Disease (TG6-IEC Chagas), part of the Chagas Disease Control Program by the World Health Organization (WHO). The purpose of this platform is to share information about the
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TG6-IEC group’s activities.
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