About six to seven million people worldwide, mostly in Latin America, are estimated to be infected with Trypanosoma cruzi, the parasite that causes Chagas disease (WHO data from 2021). Chagas disease is found mainly in endemic areas of 21 Latin American countries. Chagas disease was once entirely confined to rural areas but in the last decades, due to population movements, most infected people live in urban settings and the disease has spread to other continents. The burden of disease is due to its chronic progression with people still suffering years later after initial infection.