The health and well-being of Africans are fundamental to Africa’s future. To ensure a healthier, more secure future, Africa has embarked on a historic effort to lay the foundation for sustainable health and development for all. Agenda 63 envisages a 50-year effort to galvanize a socioeconomic transformation across the continent. A key element of this transformation involves harnessing the “demographic dividend” to drive progress towards increased economic growth, social development and shared prosperity. The African Union’s ‘Africa Health Strategy’ and the ‘Catalytic Framework to End AIDS, TB and Eliminate Malaria by 2030 provide key goals, strategies and milestones for the journey towards a healthy and prosperous Africa. Making optimal use of technology, including digital communications platforms where feasible, will play a pivotal role in achieving these aims.