Q 1: Are antidepressants (Tricyclic Antidepressants (TCA) and Selective Serotonin Reuptake Inhibitors (SSRI)) better (more
effective than/as safe as) than treatment as usual (placebo) in adults with depressive episode/disorder?
Sci Rep. 2016; 6: 25920. Published online 2016 May 16. doi: 10.1038/srep25920
This guide covers: Treatment That Works; Myths About Treatment; Success Stories; Resources | Do you or a loved one have PTSD? There is no need to suffer. Treatment works. If you have PTSD—posttraumatic stress disorder — you don’t have to suffer. There are good treatments that can help. This b...ooklet describes therapies and medications that are proven to help people with PTSD.
You’ll hear from experts about what treatment is like, and how it can help you. Don’t let PTSD get in the way of your enjoyment of life, hurt your relationships, or cause problems for you at
work or school. PTSD treatment works.
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Abstract: Posttraumatic stress disorder (PTSD) is a chronic psychological disorder that can develop after exposure to a traumatic event. This review summarizes the literature on the epidemiology, assessment, and treatment of PTSD. We provide a review of the characteristics of PTSD along with associa...ted risk factors, and describe brief, evidence-based measures that can be used to screen for PTSD and monitor symptom changes over time. In regard to treatment, we highlight commonly used, evidence-based psychotherapies and pharmacotherapies for PTSD. Among psychotherapeutic approaches, evidence-based approaches include cognitive-behavioral therapies (e.g., Prolonged Exposure and Cognitive Processing Therapy) and Eye Movement Desensitization and Reprocessing. A wide variety of pharmacotherapies have received some level of research support for PTSD symptom alleviation, although selective serotonin reuptake inhibitors have the largest evidence base to date.
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Q4: For people with dementia with associated depression, do antidepressants when compared to placebo/comparator produce benefits/harm in the specified outcomes?
Dialogues Clin Neurosci. 2017 Jun; 19(2): 93–107.
International Journal of Psychiatry in Clinical Practice, 2012; 16: 77–84
WHO guidelines on the pharmacological treatment of persisting pain in children with medical illnesses
Q 2: How long should treatment with antidepressants continue in adults with depressive episode/disorder?
Anxiety disorders
Chapter F.5
Q10: Are antidepressants (Tricyclic antidepressants (TCA), Selective serotonin reuptake inhibitors (SSRIs)) effective and safe in children 6-12 years of age with depressive episode/disorder?
Occasional anxiety is a normal part
of life. You might worry about things
like health, money, or family
problems. But people with
generalized anxiety disorder (GAD)
feel extremely worried or feel
nervous about these and other
things—even when there is little or
no reason to worry about the...m.
People with GAD find it difficult to
control their anxiety and stay
focused on daily tasks.
The good news is that GAD is
treatable. Call your doctor to talk
about your symptoms so that you
can feel better.
more
Do you sometimes have sudden attacks of
anxiety and overwhelming fear that last for
several minutes? Maybe your heart pounds,
you sweat, and you feel like you can’t
breathe or think. Do these attacks occur at
unpredictable times with no obvious trigger,
causing you to worry about the possibi...lity of
having another one at any time?
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Standard Treatment Guideline
As part of the Mental Health Gap Action Programme, WHO has developed training manuals (Training of trainers and supervisors training manual and Training of health-care providers training manual) to support implementation of the mhGAP Intervention Guide for mental, neurological and substance use (MNS...) disorders in non-specialized health settings, version 2.0. These manuals can be used to build capacity among non-specialist health-care providers in the assessment and management of people with priority MNS conditions in low resource settings.
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For each medicine the Formulary provides information on use, dosage, adverse effects, contraindications and warnings, supplemented by guidance on selecting the right medicine for a range of conditions
(2015)
Scoping question: Are antidepressants (specifically, tricyclic antidepressants and selective serotonin reuptake inhibitors) effective and safe in adolescents with moderate-severe depressive disorder for whom psychosocial interventions have proven ineffective?
This twelfth version of the WHO living guideline now contains 19 recommendations. This latest update provides updated recommendations for remdesivir, addresses the use of combination therapy with corticosteroids, interleukin-6 (IL-6) receptor blockers and Janus kinase (JAK) inhibitors in patients wi...th severe or critical COVID-19, and modifies previous recommendations for the neutralizing monoclonal antibodies sotrovimab and casirivimab-imdevimab in patients with non-severe COVID-19.
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An Evidence-Based Treatment Guide for Clinicians