On 20 March 2020, Pope Francis asked the Dicastery for Promoting Integral Human Development (DPIHD) to create a Commission, in collaboration with other Dicasteries of the Roman Curia and other organizations, to express the Church’s solicitude and care for the whole human family facing the COVID-19 pandemic, including analysis, reflection on the new socio-economic-cultural future, and the proposal of relevant approaches. Accordingly, DPIHD has established a Vatican COVID-19 Commission to take up the Pope’s concern through the activities of five Working Groups, which are: acting now for the future; looking to the future with creativity; communicating hope; seeking common dialogue and reflections; supporting to care.