Strict storage recommendations for insulin are difficult to follow in hot tropical regions and even more challenging in conflict and humanitarian emergency settings, adding an extra burden to the management of people with diabetes. According to pharmacopeia unopened insulin vials must be stored in a... refrigerator (2–8°C), while storage at ambient temperature (25–30°C) is usually permitted for the 4-week usage period during treatment. In the present work we address a critical question towards improving diabetes care in resource poor settings, namely whether insulin is stable and retains biological activity in tropical temperatures during a 4-week treatment period. To answer this question, temperature fluctuations were measured in Dagahaley refugee camp (Northern Kenya) using log tag recorders. Oscillating temperatures between 25 and 37°C were observed. Insulin heat stability was assessed under these specific temperatures which were precisely reproduced in the laboratory. Different commercialized formulations of insulin were quantified weekly by high performance liquid chromatography and the results showed perfect conformity to pharmacopeia guidelines, thus confirming stability over the assessment period (four weeks). Monitoring the 3D-structure of the tested insulin by circular dichroism confirmed that insulin monomer conformation did not undergo significant modifications. The measure of insulin efficiency on insulin receptor (IR) and Akt phosphorylation in hepatic cells indicated that insulin bioactivity of the samples stored at oscillating temperature during the usage period is identical to that of the samples maintained at 2–8°C. Taken together, these results indicate that insulin can be stored at such oscillating ambient temperatures for the usual four–week period of use. This enables the barrier of cold storage during use to be removed, thereby opening up the perspective for easier management of diabetes in humanitarian contexts and resource poor settings.
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Epidemiologische Lage
Grundsätze für die Hausärztliche Praxis
Organisatorische Hinweise
Mögliche Optionen zur Entlastung der Praxis
Klinische Hinweise zur Behandlung von Covid-19-Fällen
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WHO/HTM/HIV/2007.01 WHO/HTM/TB/2007.380
Haiti is one of the worst food crises in the world with 46 percent of the population projected to be in high acute food security, mainly due to reduced agricultural production caused by a long period of drought, storms and increased prices of basic foodstuffs, which are compounded by the effects of ...the coronavirus disease 2019 (COVID-19).
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Près de deux ans après la signature de l’Accord Politique pour la Paix et la Réconciliation (APPR), la population centrafricaine est toujours l’otage d’un environnement sécuritaire instable et imprévisible. La poursuite des conflits dans plusieurs zones du pays, les faiblesses structurell...es conjuguées aux effets socio-économiques de la pandémie de COVID-19 et aux effets dévastateurs des catastrophes naturelles ont plongé 2,8 millions de personnes dans une grande vulnérabilité. Sur ce total, 1,9 million connaissent des besoins humanitaires sévères, un chiffre inégalé depuis 5 ans qui traduit une détérioration du bien-être physique et mental et des conditions de vie des populations dans l’ensemble du pays.
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Maphunziro Othandiza Kusankha Mwanzeru Polimbana ndi Mliri wa Edzi. Bukhu Lophunzitsira Kudzilet sa ku Edzi M’malawi
Members of the FETP Learning Advisory Council (FLAC) have curated a list of reliable sources for learning on COVID-19 and related topics, relevant during an active infectious disease outbreak.
These resources are organized into the following categories, which are then organized by types of resource... (such as online course, recorded webinar, report, article, training material, scientific publication, dashboard, and tracker):
Training
Other knowledge hubs and sharing platforms
Organizational and government responses
Research
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Accessed 3rd of October 2015
L’analyse des besoins humanitaires en Haïti a révélé que plus de 4,4 millions d’Haïtiens et d’Haïtiennes, soit environ 40% de la population, auront besoin d’une assistance humanitaire en 2021.
Le Burkina Faso est l’un des pays les plus pauvres du monde avec peu de donateurs institutionnels œuvrant directement à la satisfaction des besoins des personnes en situation de handicap. En tant que pays prioritaire de LIGHT FOR THE WORLD ainsi que de la Coopération Autrichienne au Développem...ent, le Burkina Faso offre de réelles opportunités pour un travail en synergie. Afin de soutenir le programme au Burkina Faso, LIGHT FOR THE WORLD a décidé d’y ouvrir un bureau pays en 2009. Ce bureau jouera un rôle crucial dans l’appui des partenaires locaux et contribuera à une transition dans le travail de LIGHT FOR THE WORLD au Burkina Faso, passant d’une série de projets indépendants à un programme complet visant à promouvoir le développement inclusif et la création d’une société inclusive. Il permet à LIGHT FOR THE WORLD d’apporter une réelle plus-value aux efforts pour la création d’une société inclusive. Cette stratégie d’intervention a été élaborée suivant un processus exhaustif: sur base d’une analyse situationnelle et d’une large consultation des acteurs principaux entre avril 2010 et mai 2011 au Burkina Faso et en Europe.
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