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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Coronavirus SARS-CoV-2/ COVID-19 Pandemic: Information and interim guidelines for pharmacists and the pharmacy workforce

International Pharmaceutical Federation (FIP) (2020) CC

The purpose of this document is to provide relevant information and guidelines on coronavirus outbreaks – and in particular the novel coronavirus SARS-CoV-2 and the diseases it produces, COVID-19 – for pharmacists and the pharmacy workforce, both in a primary care context (i.e. community phar... more

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Upgrading Guidelines/Information of Health Facilities and Utilities Ministry of Health Republic of Zambia March

Ministry of Health, Zambia (2016) C1

The Ministry of Health together with its partners realizes that efficient and effective delivery of clinical care is highly dependent on the availability of appropriately upgraded environment, which is in well facilitated space. Such facilities and utilities should always be properly designed, bu... more

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Hepatitis B (chronic): Diagnosis and management of chronic hepatitis B in children, young people and adults

Aftab Ala, Elizabeth Boxall, Steven Bradley et al. National Clinical Guideline Centre (2013)

Clinical guideline, Methods, Evidence and Recommendations In this guideline the following is covered: information needs of people with chronic hep titis B and their carers; where children, young people and adults with chronic hepatitis B a- should be assessed; assessment of liver disease, includi... more

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Diagnosis and management of epilepsy in adults

Healthcare Improvement Scotland Scottish Intercollegiate Guideline Network (2018) C1

SIGN 143. A national clinical guideline Published May 2015, Revised 2018

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The Critical Role of the Staff Nurse in Antimicrobial Stewardship—Unrecognized, but Already There

Olans R. N. , R. D. Olans, A. DeMaria Jr Clinical Infectious Diseases (2016) C2

An essential participant in antimicrobial stewardship who has been unrecognized and underutilized is the“staff nurse.”Although the role of staff nurses has not formally been recognized in guidelines for implementing and operating antimicrobial stewardship programs (ASPs) or defined in the medica... more

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Impact of COVID-19 on Pediatric Asthma: Practice Adjustments and Disease Burden

Papadopoulos, N.G.; Custovic, A.; Deschildre, A. et al. The Journal of Allergy and Clinical Immunology: In Practice (2020) CC

Coronavirus disease 2019 has a mild disease course in children and adolescents. Chronic respiratory conditions, including asthma, have been suggested as risk factors; however, asthma in children is highly variable in both triggers and severity. During the pandemic, pediatric asthma services limite... more

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Panduan Penatalaksanaan Klinis Pembesaran Prostat Jinak (Benign Prostatic Hyperplasia/BPH)

Mochtar, C.A., R. Umbas, D.M. Soebadi, et al., Indonesian Urological Association (2015) C1

Clinical Guidelines for Therapy Management of Benigne Prostate Hyperplasia in Indonesia 2015

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MSF الإرشادات السريرية. دليل التشخيص والعلاج
recommended

Médecins sans Frontières (MSF) (2022) C2

Clinical Guidelines. Diagnosis and Treatment Manual.

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Lineamientos técnicos para la atención de personas con tuberculosis presuntiva y seguimiento de casos diagnosticados, en el marco de la pandemia por COVID-19

Dr. Francisco José Alabí Montoya, Dr. Carlos Gabriel Alvarenga Cardoza, Dra. Karla Marina Díaz de Naves Ministerio de Salud El Salvador (2021) C1

Clinical guidelines for the care of persons with suspected tuberculosis and and follow-up of diagnosed cases, in the context of the COVID-19 pandemic

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Médecins Sans Frontières (MSF) Guidance App
recommended

Médecins sans Frontières (2014) C3

For those with smartphones, you can install the free ‘MSF Guidance’ app by the Open Medicine Project from the app store. It includes the MSF guidelines on Ebola and Marburg virus disease. MSF guidance is an easily searchable app with all the latest MSF clinical protocols and essential drug info... more

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Pneumonia Nosokomial

The Indonesian Association of Pulmonologist (2003) C1

Clinical Guidelines for the Diagnose and Management of Nosocomial Pneumonia in Indonesia

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Epilepsies: diagnosis and management
recommended

National Institute for Health and Care Excellence (NICE) (2012) C2

Clinical guideline | Published: 11 January 2012 | nice.org.uk/guidance/cg137

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Bipolar disorder: assessment and management

National Institute for Health and Care Excellence (NICE) (2014) CC

Clinical Guideline

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Defeating Cholera

Centers for Disease Control and Prevention CDC (2010) C_CDC

Clinical Presentation and Management for Haiti Cholera Outbreak, 2010 The document provides detailed guidelines for diagnosing and managing cholera cases, with a focus on rehydration therapy and preventing dehydration-related fatalities. It outlines the use of oral rehydration salts (ORS), intrav... more

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Kangaroo Mother Care

KMC India Network Save the Children (2004) C1

Clincial Practice Guidelines

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Responding to children and adolescents who have been sexually abused
recommended

World Health Organization WHO (2017) C_WHO

WHO clinical guidelines. For the first time, WHO has published guidelines to help (primarily) front-line healthcare providers give high-quality, compassionate, and respectful care to children and adolescents (up to age 18) who have or may have experienced sexual abuse, including sexual assault or r... more