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Research priorities for Chagas disease, human African trypanosomiasis and leishmaniasis

World Health Organization WHO (2012) C_WHO
This report provides a review and analysis of the research landscape for three diseases – Chagas disease, human African trypanosomiasis and leishmaniasis – that disproportionately afflict poor and remote populations with limited access to health services. It represents the work of the disease re... more
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Chagas Clinical Research Platform

Drugs for Neglected Diseases Initiative DNDi Latin America (2022) CC
To support its R&D activities on Chagas disease, DNDi launched the Chagas Clinical Research Platform (CCRP). The platform brings together partners, experts, and stakeholders to provide support for evaluation and development of new treatments for Chagas disease. The patient-centred platform aims to f... more
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Full prescribing information Fexinidazole tablets, for oral use

Drugs for Neglected Diseases initiative DNDi (2021) C1
Full Perscribing information on Fexinidazole Tablet for oral use INDICATIONS AND USAGE Fexinidazole Tablets are indicated for the treatment of both the first-stage (hemolymphatic) and second-stage (meningoencephalitic) human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense in pati... more
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Describing nearly two decades of Chagas disease in Germany and the lessons learned: a retrospective study on screening, detection, diagnosis, and treatment of Trypanosoma cruzi infection from 2000 – 2

Guggenbühl Noller, J.M., Froeschl, G., Eisermann, P. et al. BMC Infectious Diseases (2020) CC
The highly complex and largely neglected Chagas disease (CD) has become a global health problem due to population movements between Latin America and non-endemic countries, as well as non-vectorial transmission routes. Data on CD testing and treatment from routine patient care in Germany of almost t... more
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Serious adverse events following treatment of visceral leishmaniasis: A systematic review and meta-analysis

Singh-Phulgenda, S., Dahal, P., Ngu, R. et al. PLOS Neglected Tropical Diseases (2021) C1
Despite a historical association with poor tolerability, a comprehensive review on safety of antileishmanial chemotherapies is lacking. We carried out an update of a previous systematic review of all published clinical trials in visceral leishmaniasis (VL) from 1980 to 2019 to document any reported ... more
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Leptospirosis in sugarcane plantation and fishing communities in Kagera northwestern Tanzania

Mgode, G.; Japhary, M.; Mhamphi, G. et al. PLoS Neglected Tropical diseases (2019) CC
Leptospirosis is a bacterial zoonotic disease of worldwide importance, though relatively neglected in many African countries including sub Saharan Africa that is among areas with high burden of this disease. The disease is often mistaken for other febrile illnesses such as dengue, malaria, rickettsi... more
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Global Burden of Human Mycetoma: A Systematic Review and Meta-analysis

Van de Sande, W. PLoS Neglected Tropical diseases (2013) CC
Mycetoma is a chronic infectious disease of the subcutaneous tissue with a high morbidity. This disease has been reported from countries between 30°N and 15°S since 1840 but the exact burden of disease is not known. It is currently unknown what the incidence, prevalence and the number of reported ... more
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Visceral leishmaniasis: a global overview

Wamai, R.; Khan, J.; McGloin, J.; Ziaggi, G. Jornal of Global Health Science (2020) CC
A group of enzootic and zoonotic protozoan infections, the leishmaniases constitute among the most severely neglected tropical diseases (NTDs) and are found in all continents except Oceania. Representing the most common infectious diseases, NTDs comprise an open-ended list of some 20 parasitic, bact... more
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Drugs to prevent COVID-19: living guideline

World Health Organisation (WHO) (2023) C_WHO
The WHO Living guideline: Drugs to prevent COVID-19 contains the Organization’s most up-to-date recommendations for the use of drugs to prevent COVID-19. The latest version of this living guideline is available in pdf format (via the ‘Download’ button) and via an online platform. Guidelines ... more
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Preventing Child and Maternal Deaths: A Framework for Action in a Changing World 2023-2030

US Agency for International Development USAID (2023) CC
Improving the survival chances and quality of life of women, newborns, and children remains an urgent global challenge. Since 2012, substantial progress has been made in reducing maternal and under-5 deaths, and a only handful of countries are on target to meet the SDG targets in 2030. Yet, 5 millio... more
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Towards a Human Rights-Based Approach to Migration: Training Guide

UN Office of the High Commissioner for Human Rights OHCHR (20023) CC
This training guide is designed to enable participants to understand the human rights perspective on migration, and how human rights laws and standards can be operationalized to make migration safer and an empowering experience for all. It provides an introduction to related principles and issues an... more
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Atrapados en la tormenta de la COVID-19: la salud de la mujer, el niño y el adolescente en el contexto de la CSU y los ODS: informe 2020: resumen de orientación

World Health Organization WHO (2020) C_WHO
Mothers, newborns, young children and adolescents are losing 20 percent of their health and social services due to the COVID-19 pandemic says a Panel of senior global health experts.
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Dans la tourmente de la pandémie de COVID-19: la santé de la femme, de l’enfant et de l’adolescent dans le contexte de la couverture sanitaire universelle et des objectifs de développement durable : r

World Health Organization WHO (2020) C_WHO
Groupe indépendant d’experts de la redevabilité de l’initiative Chaque femme, chaque enfant. (‎2020)‎. Dans la tourmente de la pandémie de COVID-19: la santé de la femme, de l’enfant et de l’adolescent dans le contexte de la couverture sanitaire universelle et des objectifs de dével... more
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Investing to overcome the global impact of neglected tropical diseases

World Health Organisation (WHO) (2015) C_WHO
The report brings a new dimension to long-term thinking about the future approach to these diseases. For the fi rst time, it sets out financing needs, options, and targets for meeting WHO Roadmap goals by 2020, but also for reaching universal coverage of all people in need by 2030. Th e report makes... more
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Rabies epidemiology, prevention and control in Nigeria: Scoping progress towards elimination

Mshelbwala, P.; Weese, J.; Sanni-Adeniyi, O. et al. PLoS Neglected Tropical diseases (2021) CC
Human rabies remains a significant public health problem in Africa with outbreaks reported in most countries. In Nigeria–the most populous country in Africa–rabies causes a significant public health burden partly due to perennial obstacles to implementing a national prevention and control progra... more
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WHO Guidelines for Malaria- 14 March 2023

World Health Organisation (WHO) (2023) C_WHO
The conditionality of this recommendation is largely driven by the current higher unit cost of pyrethroid-PBO ITNs compared to pyrethroid-only LLINs and therefore the uncertainty of their cost-effectiveness. Furthermore, as PBO is less wash-resistant than pyrethroids, its bioavailability declines ... more
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Clinical management of COVID-19: living guideline, 13 January 2023

World Health Organisation (WHO) (2023) C_WHO
As of 12 December 2022, over 645 million people worldwide have been diagnosed with COVID-19, with over 6.6 million deaths (4). The Omicron variant, which emerged in late November 2021, and its subvariants, are now the dominant circulating viruses, contributing to the ongoing surge in several countr... more
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Trends in maternal mortality 2000 to 2020: estimates by WHO, UNICEF, UNFPA, World Bank Group and UNDESA/Population Division

World Health Organisation (WHO) (2023) C_WHO
Every day in 2020, approximately 800 women died from preventable causes related to pregnancy and childbirth - meaning that a woman dies around every two minutes. Sustainable Development Goal (SDG) target 3.1 is to reduce maternal mortality to less than 70 maternal deaths per 100 000 live births by ... more
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Building Resilient Health Systems to Advance toward Universal Health in the Americas: Lessons from COVID-19

Pan American Health Organization (PAHO) (2023) C_WHO
This brochure presents a summary of the situation of health systems and services in the Americas as they progress toward the achievement of universal access to health and universal health coverage (universal health). The information provided presents an overview of the situation before the COVID-19 ... more
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Promoting Wellbeing and Mental Health in Schools

Pan American Health Organization (PAHO) (2023) C_WHO
This Handbook is primarily for educators, to help them learn about mental health issues and better support them in educational environments. The Handbook aims to provide training to teachers, administrators, and people involved in the education of primary school children about the implementation of ... more