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Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are
...
limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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Parasites & Vectors volume 15, Article number: 389 (2022)
Dengue is one of the common arboviral infections and is a public health problem in South East Asia. The aim of this systematic review and meta-analysis was to evaluate the prevalence and distribution of dengue in SAARC (South Asian Associ
...
ation for Regional Cooperation) countries.
more
Indian J Psychiatry. 2012 Jan-Mar; 54(1): 41–47.
doi: 10.4103/0019-5545.94644
Indian J Psychol Med. 2017 Jan-Feb; 39(1): 46–51.
doi: 10.4103/0253-7176.198949
Mental health and poor recovery in female nursing workers: a contribution to the study of gender inequities
Lúcia Rotenberg,1 Aline Silva-Costa,1 and Rosane Härter Griep
Pan American Health Organization PAHO
(2017)
C_WHO
Rev Panam Salud Publica. 2014;35(3):179–85
Lancet 2012; 380: 1193–1201
Series: Epilepsy 2
The Global Burden of Disease Study (GBD) is the most comprehensive worldwide observational epidemiological study to date. It describes mortality and morbidity from major diseases, injuries and risk factors to health at global, national and regional levels. Examining trends from 1990 to the present a
...
nd making comparisons across populations enables understanding of the changing health challenges facing people across the world in the 21st century.
Accessed July 4, 2019
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This paper looks at the increasing use of 'new psychoactive substances', a term which is defined differently by different people, but which is here defined as 'narcotic drugs or psychotropic substances made available or used from the early to mid-2000s for their psychoactive properties'
Series: Ser
...
ies|Drug Use| Volume 394, ISSUE 10209, P1668-1684, November 02, 2019
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Open AccessPublished:March 28, 2019DOI:https://doi.org/10.1016/S1473-3099(18)30730-8
The Lancet Infectious Diseases
Les programmes de planification familiale sont une solution gagnant-gagnant ; le bien-être de chaque femme et des enfants est amélioré, et l'économie nationale et l'environnement en tirentles bénéfices
Bull World Health Organ 2016;94:554–556 | doi: http://dx.doi.org/10.2471/BLT.15.162610
After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery for HAT with special emphasis on the discovery, pre-clinical development, and operational challenge
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s of the clinical trials of fexinidazole. The screening of the Drugs for Neglected Diseases initiative (DNDi) HAT-library by the Swiss TPH had singled out fexinidazole, originally developed by Hoechst (now Sanofi), as the most promising of a series of over 800 nitroimidazoles and related molecules. In cell culture, fexinidazole has an IC50 of around 1 µM against Trypanosoma brucei and is more than 100-fold less toxic to mammalian cells. In the mouse model, fexinidazole cures both the first, haemolymphatic, and the second, meningoencephalitic stage of the infection, the latter at 100 mg/kg twice daily for 5 days. In patients, the clinical trials managed by DNDi and supported by Swiss TPH mainly conducted in the Democratic Republic of the Congo demonstrated that oral fexinidazole is safe and effective for use against first- and early second-stage sleeping sickness. Based on the positive opinion issued by the European Medicines Agency in 2018, the WHO has released new interim guidelines for the treatment of HAT including fexinidazole as the new therapy for first-stage and non-severe second-stage sleeping sickness caused by Trypanosoma brucei gambiense (gHAT). This greatly facilitates the diagnosis and treatment algorithm for gHAT, increasing the attainable coverage and paving the way towards the envisaged goal of zero transmission by 2030.
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Lancet 2013; 381: 1405–16
Series: Childhood Pneumonia and Diarrhoea no.1
Lancet. 2018 Dec 19. pii: S0140-6736(18)31647-7. doi: 10.1016/S0140-6736(18)31647-7. [Epub ahead of print]
Rund drei Viertel der in Deutschland lebenden Flüchtlinge aus Syrien, dem Irak und Afghanistan sind nach Gewalterlebnissen traumatisiert.
Neue Empfehlungen für die Umgebungsuntersuchungen bei Tuberkulose
Diel, R., G. Loytved, A.Nienhaus, et al.
Deutsches Zentralkomitee zur Bekämpfung der Tuberkulose
(2011)
C2
DOI http://dx.doi.org/ 10.1055/s-0030-1256439 Online-Publikation: 10. 5. 2011 Pneumologie 2011; 65: 359–378
La crisis del sistema de salud colombiano: una aproximación desde la legitimidad y la regulación
recommended
Suárez-Rozo LF, Puerto-García S, Rodríguez-Moreno LM, Ramírez-Moreno
Rev. Gerenc. Polit. Salud, Bogotá, Colombia
(2017)
C1
El objetivo fue determinar cuáles son las percepciones de distintos actores del sistema de salud
colombiano sobre los problemas del sistema que están detrás de la crisis. Se realizó un estudio
cualitativo a partir de entrevistas semiestructuradas y en profundidad con cuarenta agentes del
sect
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or salud, en Bogotá, Cali, Ibagué, Espinal y Calima-Darién. Los resultados mostraron que la
corrupción, el incumplimiento de normas y los conflictos entre los intereses de diversos actores
del sistema debilitan la legitimidad de este último, atomizan la cooperación y cohesión de los
actores y fortalecen el interés particular.
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DOI: 10.1126/science.aax2196; Science 08 Mar 2019: Vol. 363, Issue 6431, pp. 1017
