Personne ne se rend dans un établissement de soins de santé pour tomber malade. On s’y rend pour aller mieux, pour accoucher, pour se faire vacciner. Cependant, des centaines de millions de gens sont confrontés à un risque accru d’infection quand ils se font soigner dans des établissements ...de santé où les services de première nécessité font défaut, y compris les services d’approvisionnement en eau, d’assainissement et d’hygiène (WASH) et les services de gestion des déchets médicaux. Non seulement l’absence de services WASH dans les établissements de santé compromet la sécurité sanitaire des patients et leur dignité, mais il peut éventuellement exacerber la propagation d’infections résistant aux antimicrobiens et compromettre les efforts faits en vue de l’amélioration de la santé maternelle et infantile.
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Chagas disease (CD) is a neglected tropical disease, endemic in Latin America, but due to migration and environmental changes it has become a global public health issue.
Chagas disease constitutes a public health problem, and Spain is the non-endemic country with the highest burden of disease outside the Americas. It represents a model for non-endemic countries regarding health policies to control the disease. This study is aimed to generate estimates of the T.cruzi... prevalence and the number of undetected and untreated individuals with the infection in Spain and to compare them with the actual number of cases reported by official sources.
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Little progress has been made since the 1960s and 1970s to widen the therapeutic arsenal against Trypanosoma cruzi, the causative pathogen of Chagas disease, which remains a frustrating and perplexing infectious disease. This chapter focuses on the strategic and operational challenges in the clinica...l drug development of a novel antitrypanosomal agent for Chagas disease. The various elements that contribute to a robust assessment of treatment effect including dose selection, choice of patient population, trial methodology, endpoint measures, and regulatory perspectives are discussed. The learnings herein should serve as resource to help researchers and other stakeholders optimize their clinical development plans and speed delivery of new medicines to patients with Chagas disease.
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Chagas disease (CD) is caused by Trypanosoma cruzi. When acquired, the
disease develops in stages. For diagnosis, laboratory confirmation is required, and an extensive assessment of the patient’s health should be performed. Treatment consists of the administration of trypanocidal drugs, which may... cause severe adverse effects. The objective of our systematic review was to analyze data contained in the CD published case reports to understand the challenges that patients and clinicians face worldwide.
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Objective
To estimate the prevalence of Chagas disease in pregnant women and the vertical transmission of the disease.
Methods
Observational studies were identified from eight electronic databases, and details on study design, population and prevalence of Chagas disease were extracted. The data... were pooled using a random-effects model, and choropleth maps were created based on geopolitical regions and countries.
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This review focusses on the interactions between the etiologic agent of Chagas disease, Trypanosoma cruzi, and its triatomine vector. The flagellate mainly colonizes the intestinal tract of the insect. The effect of triatomines on trypanosomes is indicated by susceptibility and refractoriness phenom...ena that vary according to the combination of the strains. Other effects are apparent in the different regions of the gut. In the stomach, the majority of ingested blood trypomastigotes are killed while the remaining transform to round stages. In the small intestine, these develop into epimastigotes, the main replicative stage. In the rectum, the population density is the highest and is where the infectious stage develops, the metacyclic trypomastigote. In all regions of the gut, starvation and feeding of the triatomine affect T. cruzi. In the small intestine and rectum, starvation reduces the population density and more spheromastigotes develop. In the rectum, feeding after short-term starvation induces metacyclogenesis and after long-term starvation the development of specific cells, containing several nuclei, kinetoplasts and flagella. When considering the effects of T. cruzi on triatomines, the flagellate seems to be of low pathogenicity. However, during stressful periods, which are normal in natural populations, effects occur often on the behaviour, eg, in readiness to approach the host, the period of time before defecation, dispersal and aggregation. In nymphs, the duration of the different instars and the mortality rates increase, but this seems to be induced by repeated infections or blood quality by the feeding on infected hosts. Starvation resistance is often reduced by infection. Longevity and reproduction of adults is reduced, but only after infection with some strains of T. cruzi. Only components of the surface coat of blood trypomastigotes induce an immune reaction. However, this seems to act against gut bacteria and favours the development of T. cruzi.
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Coherent Market Insights has announced the addition of Chagas Disease Treatment Market 2023 Forecast Analysis by Types, Applications, Size, Share, Key Players, and Regions. a new research report to its market research archive. The Chagas Disease Treatment Market has been thoroughly researched and an...alyzed by industry experts and researchers. The industry is examined at the global, regional, and national levels. The report highlights the primary revenue stream for the estimated year, along with sales volumes, growth patterns, and major industry market dynamics. The historical data is provided, as well as a comprehensive revenue analysis for the forecast period. The report focuses on the size, share, growth status, and future trends of the Chagas Disease Treatment Market, as well as recent business developments.
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Leishmaniasis is a spectrum of disease caused by the infection of protozoan parasite Leishmania mainly affecting the antigen presenting cell of the host. The disease is although considered as neglected tropical disease still it is not completely eradicated. Majority of the issues related to the ther...apeutic approach is due to increased cytotoxicity of the drugs, less effectiveness, high cost and occurrence of drug resistance. Therefore, recent advancement in the field of parasitology has taken into consideration of the specific arms of immunity which can be triggered with the help of natural products, synthetic molecules or parasite specific ligands which helps in the restoration of host protective immunity and recovery from the infection. Therefore, in this review, we have highlighted the recent advancement in the field of Leishmania research taken into consideration of the therapeutic perspective. We have shown that apart from therapeutic potential of the available drugs and vaccination approach, the immune-therapy are emerging as the modern regime of treatment where the effectiveness of the therapy is significantly increased and making it safer and promising.
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Small drinking-water supplies commonly experience operational, managerial, technical and resourcing challenges that impact their ability to deliver safe and reliable services. The needs and opportunities associated with these supplies therefore warrant explicit consideration in policies and regulati...ons.
These Guidelines, specifically tailored to small water supplies, build on over 60 years of guidance by the World Health Organization (WHO) on drinking-water quality and safety. They focus on establishing drinking-water quality regulations and standards that are health based and context appropriate; on proactively managing risks through water safety planning and sanitary inspections; and on carrying out independent surveillance. The guidance is intended primarily for decision-makers at national and subnational levels with responsibility for developing regulatory frameworks and support programmes related to these activities. Other stakeholders involved in water service provision will also benefit from the guidance in this document.
Designed to be practical and accessible, these Guidelines offer clear guidance that is rooted in the principle of progressive improvement. State-of-the-art recommendations and implementation guidance are provided, drawn from a comprehensive evidence review and established good practices. Additionally, case examples are provided from countries and areas around the world to demonstrate how the guidance in this publication has been implemented in practice in a wide variety of contexts.
Together with WHO’s 2024 Sanitary inspection packages – a supporting tool for the Guidelines for drinking-water quality: small water supplies, these Guidelines update and supersede WHO’s 1997 Guidelines for drinking-water quality. Volume 3: surveillance and control of community supplies. Key changes to this updated publication include a greater focus on preventive risk management and a broader range of small water supplies covered, including those managed by households, communities and professional entities.
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The Guidelines for drinking-water quality: small water supplies have been developed to address the needs and opportunities associated with small supplies to facilitate progressive improvement towards safe and sustainable drinking-water services for all. These Guidelines are based on the principal re...commendation in the World Health Organization’s Guidelines for drinking-water quality, and they provide guidance on applying that recommendation to small water supplies in particular. These Guidelines aim to help governments and practitioners improve the safety of drinking-water delivered through small supplies.
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Ces Directives sur la qualité de l’eau de boisson : petits approvisionnements en eau ont été élaborées pour aborder les besoins et les possibilités associés aux petits approvisionnements afin de favoriser l’amélioration progressive vers des services d’alimentation en eau de boisson sû...rs et durables pour tous. Ces directives se fondent sur la principale recommandation des Directives de qualité pour l’eau de boisson de l’Organisation mondiale de la santé ; elles visent à fournir des orientations concernant l’application de cette recommandation aux petits approvisionnements en eau en particulier. Ces directives visent à aider les gouvernements et les praticiens à améliorer la sécurité sanitaire de l’eau de boisson fournie par de petits approvisionnements.
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Las Guías para la calidad del agua de consumo humano: pequeños sistemas de abastecimiento de agua se han elaborado para tratar las necesidades y oportunidades asociadas a los pequeños sistemas de abastecimiento, con el fin de facilitar la mejora progresiva hacia unos servicios seguros y sostenibl...es de agua de consumo humano para todas las personas. Estas Guías se basan en la recomendación principal de las Guías para la calidad del agua de consumo humano de la Organización Mundial de la Salud, y proporcionan orientación sobre la aplicación de esas recomendaciones a los pequeños sistemas de abastecimiento de agua en particular. El objetivo de estas Guías consiste en ayudar a los gobiernos y a los profesionales a mejorar la seguridad del agua de consumo humano suministrada a través de pequeños sistemas de abastecimiento.
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Настоящее «Руководство по обеспечению качества питьевой воды: маломасштабные системы водоснабжения» было разработано для удовлетворения потребностей и использ...вания возможностей, связанных с маломасштабными системами водоснабжения, в целях содействия постоянному совершенствованию системы устойчивого снабжения всего населения безопасной питьевой водой. Настоящее Руководство основано на главной рекомендации Руководства по обеспечению качества питьевой воды Всемирной организации здравоохранения и содержит руководящие указания в отношении выполнения этой рекомендации, в частности применительно к маломасштабным системам водоснабжения. Настоящее Руководство призвано помочь правительствам и отрасли повысить безопасность питьевой воды, доставляемой маломасштабными системами водоснабжения.
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وقد وُضعت هذه الإرشادات المعنونة "إرشادات بشأن مياه الشرب: إمدادات المياه الصغيرة" لتناول الاحتياجات والفرص المرتبطة
بإمدادات المياه الصغيرة وتيسير التحسين التد...ريجي نحو خدمات مياه شرب آمنة ومستدامة للجميع.
تستند هذه الإرشادات إلى التوصية الرئيسية الواردة في إرشادات منظمة الصحة العالمية بشأن جودة مياه الشرب وتوفّر إرشادات حول تطبيق هذه التوصية على إمدادات المياه صغيرة الحجم على وجه الخصوص.
تهدف هذه الإرشادات إلى مساعدة الحكومات والممارسين على تحسين سلامة مياه الشرب المقدمة من خلال الإمدادات الصغيرة.
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