J Acquir Immune Defic Syndr Volume 78, Supplement 1, August 15, 2018
Abstract: Chagas disease is caused by infection with the protozoan Trypanosoma cruzi, and although over 100 years have passed since the discovery of Chagas disease, it still presents an increasing problem for global public health. A plethora of information concerning the chronic phase of human Chaga...s disease, particularly the severe cardiac form, is available in the literature. However, information concerning events during the acute phase of the disease is scarce. In this review, we will discuss the current status of acute Chagas disease cases globally, the immunological findings related to the acute phase and their possible influence in disease outcome, and reactivation of Chagas disease in immunocompromised individuals, a key point for transplantation and HIV invection management.
more
Sleeping sickness is controlled by case detection and treatment but this often only reaches less than 75% of the population. Vector control is capable of completely interrupting HAT transmission but is not used because of expense. We conducted a full scale field trial of a refined vector control tec...hnology. From preliminary trials we determined the number of insecticidal tiny targets required to control tsetse populations by more than 90%. We then carried out a full scale, 500 km2 field trial covering two HAT foci in Northern Uganda (overall target density 5.7/km2). In 12 months tsetse populations declined by more than 90%. A mathematical model suggested that a 72% reduction in tsetse population is required to stop transmission in those settings. The Ugandan census suggests population density in the HAT foci is approximately 500 per km2. The estimated cost for a single round of active case detection (excluding treatment), covering 80% of the population, is US$433,333 (WHO figures). One year of vector control organised within country, which can completely stop HAT transmission, would cost US$42,700. The case for adding this new method of vector control to case detection and treatment is strong. We outline how such a component could be organised.
more
Lunsar, Port Loko District, Sierra Leone
This catalogue provides tools and information resources to support EU/EEA countries in addressing the challenging issue of vaccine hesitancy. The catalogue provides examples of practices that can serve as a resource for other countries. The project was developed in the context of ECDC’s support fo...r EU/EEA Member States in prevention and control of vaccine-preventable diseases, including effective communication to promote immunisation.
more
Q14. SCOPING QUESTION: In adults with psychotic disorders (including schizophrenia), what is the comparative effectiveness and safety of second-generation antipsychotic medications?
This study was designed to examine the knowledge, attitude and beliefs about causes, manifestations and treatment of mental illness among adults in a rural community in
northern Nigeria.
Q1: In individuals with psychotic disorders (including schizophrenia), are antipsychotic drugs safe and effective?
In the last quarter century, several projects emerged to reform mental health services in Latin American and Caribbean countries. Some did not survive the difficulties that inevitably arise in processes of change, and ended up disappearing before the intended changes could be introduced. Others, how...ever, as shown in this publication, were able to overcome difficulties and meet intended objectives, effectively transforming the structure and quality of services. All these projects, including the many that did not survive, were part of one of the richest experiences in the transformation of mental health care worldwide - the experience of mental health reform in Latin America and the Caribbean
more
Clinical Pharmacology: Advances and Applications, 2025:17 29–47
Le Plan Stratégique National de Communication pour le Changement Social et des Comportements en matière de Lutte contre le Paludisme 2021–2025 de la Côte d’Ivoire définit les grandes lignes pour améliorer la prévention et la prise en charge du paludisme à travers la communication. Il vise... à changer durablement les comportements des populations, en mettant l’accent sur l’utilisation correcte des moustiquaires imprégnées, le recours précoce au diagnostic et au traitement, et la participation active des communautés. Le document identifie les publics cibles, les messages clés, les canaux de communication adaptés (médias, acteurs communautaires, écoles, etc.) et prévoit des mécanismes de suivi-évaluation. L’objectif final est de réduire la morbidité et la mortalité liées au paludisme, en mobilisant tous les acteurs nationaux et locaux autour d’une communication efficace et inclusive.
more
Ce rapport présente les résultats de la troisième année de l’ECPSS réalisée en 2015 par l’Agence Nationale de la Statistique et de la Démographie et le Ministère de la Santé et de l’Action Sociale.