Eaton JW et al. Journal of the International AIDS Society 2019, 22(S1):e25237 http://onlinelibrary.wiley.com/doi/10.1002/jia2.25237/full | https://doi.org/10.1002/jia2.25237
PLoS Med 15(7): e1002615. https://doi.org/10.1371/journal. pmed.1002615
Research Article
Karo et al. BMC Infectious Diseases 2014, 14:148 http://www.biomedcentral.com/1471-2334/14/148
dos Santos et al. BMC Public Health 2014, 14:80 http://www.biomedcentral.com/1471-2458/14/80
Lessons learned from an M&E task-shifting initiative in Botswana
Kulkarni et al. The Journal of Headache and Pain (2015) 16:67 DOI 10.1186/s10194-015-0549-x
BMC Family Practice201415:165, DOI: 10.1186/1471-2296-15-165
Open Access
BMC Public Health (2019) 19:1608
https://doi.org/10.1186/s12889-019-7853-3
BMC Medicine201614:112 DOI: 10.1186/s12916-016-0660-0
(7th Version)
20, March 2020
Arsenical monotherapies were previously very successful for treating human African trypanosomiasis (HAT).
Melarsoprol resistance emerged as early as the 1970s and was widespread by the late 1990s.
Melarsoprol resistance represents the only example of widespread drug resistance in HAT patients wher...e the genetic mechanism has been established.
The current goal of elimination of HAT as a public health problem by 2020 may be undermined by the emergence and spread of resistance to current or new drugs.
Insights into potential resistance mechanisms for current and new drugs will facilitate predictions of the likelihood of resistance and will also facilitate rational approaches to minimizing, monitoring, and tackling the future emergence of resistance.
more