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Ethical considerations for use of unregistered interventions for Ebola viral disease

World Health Organization (2014)
West Africa is experiencing the largest, most severe, most complex outbreak of Ebola virus disease in history. On 11 August 2014, WHO convened a consultation where the participants concluded that in the particular context of the current Ebola outbreak in West Africa, it is ethically acceptable to of... more
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Severe Acute Malnutrition Update: Current WHO Guidelines and the WHO Essential Medicine List for Children

Williams, Phoebe CM.; Berkley, James A. (2016) C1
This document was prepared in response to a need to review and potentially update the current recommendations for the antibiotic treatment of both inpatient and outpatient management of severe acute malnutrition (SAM). The current recommendations (Table 1) are based on guidelines published in 2013 i... more
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Field use of molluscicides in schistosomiasis control programmes: an operational manual for programme managers

World Health Organization (WHO) (2017) C_WHO
Recent systematic reviews and meta-analysis of the impact of chemical-based mollusciciding (King et al., 2015, Sokolow et al., 2016) have concluded that regular mollusciciding is likely to contribute significantly towards elimination of schistosomiasis in high-risk areas. The WHO roadmap’s new foc... more
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Rapid Evaluation of the Medicines Registration System in Benin

Diadié Maïga, Bedel Evi, Angélique Gbaguidi USAID, SIAPS (2016) C_WHO
The primary role of Benin’s Department of Pharmacy and Medicines (DPMED) is to develop and apply the national pharmaceutical policy. The main objective of this policy is to ensure the availability and accessibility of quality medicines for the population. To fulfill its mandate, DPMED aims to stre... more
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Alternative drinking-water disinfectants: Bromine, iodine and silver

World Health Organization (WHO) (2018) CC
Disinfection of drinking-water supplies has been one of the most significant public health advancements of the last century with respect to reducing waterborne disease.
Although chlorine has been used as the disinfectant of choice for public drinking-water supplies for the past century, a numbe... more
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A systematic review of online interventions for mental health in low and middle income countries: A neglected field

Arjadi , R.; Nauta, M. H.; Chowdhary, N.; et al. Global Mental Health (2015) C1
Glob Ment Health (Camb). 2015; 2: e12. Published online 2015 Jul 14. doi: 10.1017/gmh.2015.10 Low and middle income countries (LMICs) are facing an increase of the impact of mental health problems while confronted with limited resources and limited access to mental health care, known as the ‘me... more
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Tracking global trends in the effectiveness of antibiotic therapy using the Drug Resistance Index

Klein E.Y., K. K .Tseng, S. Pant, et al. BMJ Global Health (2019) C2
BMJ Global Health, Vol. 4 (2019) no.2 Antibiotic resistance is threatening global health, development and food security; however, measures for assessing and communicating the threat of resistance are lacking. The Drug Resistance Index (DRI) allows for global assessment of the relative efficacy of ... more
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Tutorial of local production of alcohol-based solution (WHO formulation)

WHO Collaborating Centre of Patient Safety Infection Control & Improving Practices; Hôpitaux Universitaires de Genève (HUG); Pharm-Ed WHO Collaborating Centre of Patient Safety Infection Control & Improving Practices; Hôpitaux Universitaires de Genève (HUG); Pharm-Ed (2016) C2
14.04.2016 Pharm -Ed -- The alcohol-based solution for hand hygiene is now part of the WHO essential medicines list .Local production of the alcohol-based handrub is an alternative to commercial products. Although adapted to contexts with limited resources, it is essential to respect the Good Man... more
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COVID-19: Chloroquine and hydroxychloroquine research

World Health Organization WHO (2020) C_WHO
This document updates the earlier version published in April 2020. In recent weeks, information on the potential use of chloroquine or hydroxychloroquine for the treatment of people with COVID-19 has been disseminated in academic journals and public media. Although there are now ongoing clinical tri... more
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COVID-19 in children and the role of school settings in COVID-19 transmission- first update

European Centre for Disease Prevention and Control ECDC (2020) C1
23 Dec 2020. The aim of this document is to provide an update on the knowledge surrounding the role of children in the transmission of SARS-CoV-2 and the role of schools in the COVID-19 pandemic, based on the experience in the EU from August–December, 2020. This document also addresses transmissio... more
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Africa CDC Consortium for COVID-19 Vaccine Clinical Trials (CONCVACT)

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C1
August 2020, The Africa Joint Continental Strategy for COVID-19 is underpinned by the need to limit transmission, prevent deaths and reduce associated harms. Participation by African nations in clinical trials is an essential step to ensure that sufficient data is generated on the safety and efficac... more
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Statement on the Use of Ivermectin for COVID-19

African Union; Africa CDC Centres for Disease Control and Prevention (2021) C1
Ivermectin is an antiparasitic drug approved for the treatment of parasitic infections, including strongyloidiasis and onchocerciasis in humans. There is a reported increase in the use of ivermectin for the prevention and treatment of COVID-19 by the public in African Union Member States. Currently... more
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AstraZeneca ChAdOx1-S/nCoV-19 [recombinant], COVID-19 vaccine

World Health Organization WHO (2021) C_WHO
10 May 2021. Manufactureres: SK Bioscience Co. Ltd. [COVID-19 Vaccine (ChAdOx1-S [recombinant])] Serum Institute of India Pvt. Ltd. [COVISHIELD™, ChAdOx1 nCoV-19 Corona Virus Vaccine (Recombinant)] The ChAdOx1-S/nCoV-19 [recombinant] vaccine is a replication-deficient adenoviral vecto... more
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Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report: 2021

World Health Organization WHO (2021) C_WHO
9 June 2021 Since its launch, GLASS has expanded in scope and coverage and as of May 2021, 109 countries and territories worldwide have enrolled in GLASS. A key new component in GLASS is the inclusion of antimicrobial consumption (AMC) surveillance at the national level highlighted in this fourth G... more
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Vaccines/COVID-19 vaccine EUL issued

World Health Organization WHO (2022) C_WHO
This chronology of facts has challenged public health systems worldwide and regulatory bodies are no exception. Regulatory authorities with mechanisms in place to authorize the use of investigational products had to development guidelines and procedures, create task forces and alliances to maximize ... more
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WHO preferred product characteristics for gonococcal vaccines

World Health Organization WHO (2021) C_WHO
Development of one or more vaccines for Neisseria gonorrhoeae is an important objective for sexual and reproductive health worldwide, and for the fight against antimicrobial resistance. WHO preferred product characteristics (PPCs) provide strategic guidance as to WHO’s preferences for new vacci... more
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The shot, the message, and the messenger: COVID-19 vaccine acceptance in Latin America

Argote P., Barhan E., Zukerman Daly S. et al. NPJ (2021) CC
Herd immunity by mass vaccination offers the potential to substantially limit the continuing spread of COVID-19, but high levels of vaccine hesitancy threaten this goal. In a cross-country analysis of vaccine hesitant respondents across Latin America in January 2021, we experimentally tested how fiv... more
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Good Practices in the Rational and Effective Use of Oxygen
recommended

Pan American Health Organisation PAHO PAHO (2021) C_WHO
In the face of rapid increases in the number of hospitalizations due to COVID-19 in Latin America and the Caribbean, coupled with shortages of human and material resources, including medical equipment and gases, there is a need to redesign models of care in the Region to optimize available resources... more
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Global roadmap for research and development of tuberculosis vaccines

European & Developing Countries Clinical Trials Partnership EDCTTP; Amterdam Institute for Global health & Development aighd (2021) C1
The roadmap describes the actions needed to achieve the three development goals for TB vaccines set by the WHO: 1. A safe, effective and affordable TB vaccine for adolescents and adults. 2. An affordable TB vaccine for neonates and infants with improved safety and efficacy. 3. A therapeutic v... more
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Malaria vaccine: WHO position paper - March 2022
recommended

World Health Organization WHO (2022) C_WHO
Weekly Epidemiological Record No 9, 2022, 97, 61–80 This position paper supersedes the 2016 publication, “Malaria vaccine: WHO position paper-2016.”1 It includes the updated WHO recommendations on the wider use of the RTS,S/AS01 vaccine for the reduction of malaria morbidity and mortality in ... more