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2
The purpose of this book is to provide an overview of Buruli ulcer (Mycobacterium ulcerans infection) for the medical and scientific communities and the general public alike.
The "Questions and Answers on Prevention and control of Alcohol related harm" has been developed by WHO country office in Viet Nam with technical contribution from national and international experts in the field. This publication provides scientific evidences on harms of alcohol use to the health of
...
users as well as to others and society at large. It provides WHO recommendations for the most effective prevention measures in Viet Nam and will also help answer questions that policy makers may have on how to develop effective policies for prevention and control of alcohol related harms.
more
Despite high regional demand for vaccines valued at over US$ 1 billion annually, Africa’s vaccine industry provides only 0.1% of global supply. Vaccine inequity and hoarding at the start of the pandemic, which resulted in delays in obtaining COVID-19 doses, stimulated new resolve to address future
...
supply security. In 2021, the AU set a target to produce and supply more than 60% of the vaccine doses on the continent by 2040.
In the last 18 months alone, more than 30 new African manufacturing projects have been announced and estimates indicate that the African vaccine market across all existing and projected novel products could range between US$ 2.8 billion and US$ 5.6 billion by 2040*, demonstrating the potential for a thriving regional industry to emerge.
more
Ces recommandations ont été élaborées dans le cadre de la mission de l’Organisation mondiale de la Santé de fournir des orientations normatives à ses États-membres. L’objectif de ce document est de formuler des recommandations fondées sur des données factuelles afin de faciliter l’acc
...
ès universel aux interventions essentielles et efficaces en matière santé maternelle et néonatale, grâce à l’optimisation des rôles du personnel de santé.
Ces recommandations s’adressent aux décideurs de la santé, aux responsables et autres acteurs aux niveaux international, national et régional. En fournissant ces recommandations générales à l’échelle internationale, l’Organisation mondiale de la Santé part du principe que les pays les adapteront et qu’ils les mettront en œuvre en tenant compte du système politique et des systèmes de santé déjà en place.
more
The power of the Global Drug Policy Index lies in its key objective: to score and
rank how countries are faring in different areas of drug policy as identified in the
UN report ‘What we have learned over the last ten years: A summary of knowledge
acquired and produced by the UN system on drug-r
...
elated matters’,1 and derived
from the landmark UN System Common Position on Drug
more
The document explains why vector control is important in national programmes and describes the preparation of a tailor-made vector control plan for national programmes. It outlines entomological procedures for regular and specific vector control and how data should be analysed for better overall und
...
erstanding of filarial transmission and vectors. The document will also be useful for teaching personnel in lymphatic filariasis programmes about the use and value
of entomological procedures in overall epidemiological appraisal in the context of
elimination
more
De 2008 à 2011, la Confédération internationale des sages-femmes (ICM) a entrepris l’élaboration des Normes globales pour la réglementation de la pratique sage-femme, parallèlement au développement des normes globales pour la formation des sages-femmes et à une mise à jour des compétence
...
s pour la pratique du métier de sagefemme. Ces normes globales, auxquelles viennent
s’ajouter les autres documents fondamentaux de l’ICM, fournissent un cadre professionnel qui peut être utilisé par les associations de sages-femmes, les organismes de réglementation de la pratique sage-femme, les formateurs de sages-femmes et
les gouvernements, pour renforcer la profession et améliorer le niveau de la pratique sage-femme dans leur pays.
more
Prévention des incapacités dans l'ulcère de Buruli : rééducation de base : guide pratique de terrain
Buruli ulcer caused by Mycobacterium ulcerans is a neglected tropical disease characterized by extensive ulceration involving predominantly the upper and lower limbs of patients. The disease is common in rural tropical communities in West and Central Africa, where access to proper health care is lim
...
ited. Pathogenesis of the characteristic painless ulcers is linked to the elaboration by M. ulcerans of a lipid toxin called mycolactone that has potent cytopathic, immunosuppressive, and analgesic effects on a host of cells in cutaneous tissues. Mycolactone is known to profoundly inhibit secretion of a plethora of proteins that are essential for wound healing. Even though a combination antibacterial therapy of streptomycin and rifampicin for 8 weeks is effective for treatment, it relies on good and appropriate wound management to prevent secondary bacterial infections and improve healing. Evidence-based interventions for wound care in Buruli ulcer disease are often lacking and have relied on expert advice and recommendations. Surgical interventions are limited to debridement of necrotic tissue and grafting of extensive ulcers, usually after antibiotic therapy. Patients’ rehabilitation is an important component of care to reduce disabilities associated with the disease and proper integration into the community after treatment.
more
This report presents key findings from a study carried out on the ‘Mainstreaming quality of care in empanelled hospitals under PMJAY’. It provides a detailed analysis of current coverage and perceptions of quality accreditation and certification across PMJAY empanelled hospitals from three diffe
...
rent states
(Haryana, Uttar Pradesh and Gujarat).
more
This global progress report attempts to lay the groundwork for the kind of accelerated action needed. Section 1 presents key data, trends and developments in women’s, children’s and adolescents’ health and well-being. That is followed in Section 2 by a deeper dive into the impact of the COVID-
...
19 pandemic, which has created and contributed to many threats and challenges to progress for women, children and adolescents. In Section 3, the report concludes with recommendations for accelerating progress towards the achievement of the 2030 Agenda even in such challenging times, with an emphasis on partnership
and clear-eyed recognition of the consequences of failing to do better.
more
Notre étude porte sur les agents de santé et la perception de leur rôle, précisément le cas des infirmiers du centre hospitalier universitaire pédiatrique Charles De Gaulle. Au Burkina Faso, tout comme ailleurs dans le monde, les infirmiers dispensent près de 80% des services de santé. Cepen
...
dant, dans la pratique leur pouvoir de responsabilité et leur autorité sont très
limités, de même qu’il existe un écart entre rôle défini et celui accompli. Ainsi on y dénote de l’ambiguïté, liée au manque de clarté des missions de son service et de précision dans leur rôle, faisant qu’ils en sont parfois désabusés. Ce qui révèle aussi que le problème pour les diverses catégories de personnel infirmier soit beaucoup lié au manque de définition précise
des rôles, et à la sous-utilisation de leurs compétences.
more
GDF is the largest global provider of quality-assured tuberculosis (TB)
medicines, diagnostics, and laboratory supplies to the public sector.
Since 2001, GDF has facilitated access to high-quality TB care in over 130
countries, providing treatments to over 30 million people with TB and procuring
...
and delivering more than $200 million worth of diagnostic equipment
more
The recommendations in this guideline are intended to inform development of national and subnational health policies, clinical protocols and programmatic guides. The target audience includes national and subnational public health policy-makers, implementers and managers of maternal, newborn and chil
...
d health programmes, health-care facility managers, supervisors/instructors for in-service training, health workers (including midwives, auxiliary nurse-midwives, nurses, paediatricians, neonatologists, general medical practitioners and community health workers), nongovernmental organizations, professional societies involved in the planning and management of maternal, newborn and child health services, academic staff involved in research and in the pre-service education and training of health workers, and those involved in the education of parents.
more
The pharmaceutical sector of any nation is responsible for providing society with quality medicines and other pharmaceutical services. According to the World Health Organization (WHO), Pharmaceuticals may constitute as much as 40% of the national health budget in developing countries, yet portions o
...
f the population may lack access to the most essential medicines; while the limited funds available for health are spent on unnecessary, ineffective and even dangerous medications.
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Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are
...
limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
more
Sexual and reproductive health is health issues that have to do with your body, sex, relationships, and having and giving birth to children. This includes having the information you need to be able to make your own decisions about your body, when to have sex, and whether or not to become a parent. T
...
his also includes having access to family planning methods—or contraceptives—
when you do not want to become pregnant. The acronym SRH is often used as a way to refer to sexual and reproductive health.
more
Método madre canguro : guía práctica
recommended
Los cuidados de la madre canguro son un método de atención a los bebés prematuros. El método consiste en llevar a los bebés, normalmente por la madre, con contacto piel con piel. Esta guía está dirigida a los profesionales de la salud responsables del cuidado de los recién nacidos de bajo pe
...
so y prematuros. Diseñada para ser adaptada a las condiciones locales, ofrece orientación sobre cómo organizar los servicios en el nivel de referencia y sobre lo que se necesita para proporcionar un cuidado eficaz de la madre canguro. La guía incluye consejos prácticos sobre cuándo y cómo puede aplicarse mejor el método de la madre canguro.
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Sector Environmental Guidelines, Full technical Update