Распространенность депрессивных расстройств и их роль в формировании различных вариантов патологии человека обусловливают актуальность поиска новых подходов к ...профилактике и лечению депрессий. Перспективным направлением может стать модификация микробиома кишечника. Основанием для разработок в этой области являются приведенные в обзоре данные исследований, подтверждающих значимость состава кишечной флоры в регуляции психических функций, в частности настроения и поведения, роль диеты в развитии депрессий. Обсуждена гипотеза о роли микробиома кишечника в развитии депрессивных расстройств. http://www.ssmj.ru/system/files/2016_02_168-174.pdf
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Front Chem. 2021; 9: 622286.
Published online 2021 Mar 12. doi: 10.3389/fchem.2021.622286
Assessment in action series
Key Findings from Azerbaijan, Georgia, Kyrgyzstan, Russia, and Ukraine
Writing by Katya Burns
Editing by Paul Silva and Roxanne Saucier
The cardiovascular disease continuum begins with risk factors such as diabetes mellitus (DM), progresses to vasculopathy and myocardial dysfunction, and finally ends with cardiovascular death. Diabetes is associated with a 2- to 4-fold increased risk for heart failure (HF). Moreover, HF patients wit...h DM have a worse prognosis than those without DM. Diabetes can cause myocardial ischemia via micro- and macrovasculopathy and can directly exert deleterious effects on the myocardium. Hyperglycemia, hyperinsulinemia, and insulin resistance can cause alterations in vascular homeostasis. Then, reduced nitric oxide and increased reactive oxygen species levels favor inflammation leading to atherothrombotic progression and myocardial dysfunction. The classification, diagnosis, and treatment of HF for a patient with and without DM remain the same. Until now, drugs targeting neurohumoral and metabolic pathways improved mortality and morbidity in HF with reduced ejection fraction (HFrEF). Therefore, all HFrEF patients should receive guideline-directed medical therapy. By contrast, drugs modulating neurohumoral activity did not improve survival in HF with preserved ejection fraction (HFpEF) patients. Trials investigating whether sodium-glucose cotransporter-2 inhibitors are effective in HFpEF are on-going. This review will summarize the epidemiology, pathophysiology, and treatment of HF in diabetes.
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This document serves to provide interim guidance/ recommendations to carry out mpox surveillance activities mainly case investigation, contact tracing and isolation. For the development of this document WHO, UKHSA and CDC guidelines were referred to and adopted within the country context.
This section provides general information on HCW and key elements of management procedures that are essential to know before developing a HCWM plan.
Pour l'achat de tests de diagnostic rapide du paludisme (TDR), plusieurs critères sont recommandés pour garantir la qualité et l'efficacité des tests. Ces critères se basent notamment sur la performance des tests, leur stabilité, leur facilité d'utilisation, leur coût et leur conformité aux... standards de l'Organisation Mondiale de la Santé (OMS)
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N95 or equivalent respirators are single-use personal protective equipment (PPE) designed for use by health workers that provide direct care to patients with diseases transmitted by aerosols or during aerosol generating procedures (AGP) for patients with acute respiratory disease, as is the case of ...COVID-19. • Given the current shortage of N95 and equivalent respirators, the World Health Organization (WHO) has suggested the possibility of their extended use by the same individual for up to 6 hours or the reprocessing of respirators when necessary.
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