Q 3: Is brief, structured psychological treatment in non-specialist health care settings better (more effective than/as safe as) than treatment as usual in people with depressive episode/disorder?
This Review summarizes many of the persistent biological alterations associated with childhood maltreatment including changes in neuroendocrine and neurotransmitter systems and pro-inflammatory cytokines in addition to specific alterations in brain areas associated with mood regulation. Finally, I d...iscuss several candidate gene polymorphisms that interact with childhood maltreatment to modulate vulnerability to major depression and PTSD and epigenetic mechanisms thought to transduce environmental stressors into disease vulnerability.
Neuron Review, vol. 89, March 2, 2016 pp.892-909
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November 3, 2009https://doi.org/10.1371/journal.pmed.1000176
PLoS Med 6(11): e1000176. https://doi.org/10.1371/journal.pmed.1000176
Recognition, Assessment and Treatment
National Clinical Guideline Number 159
Advice on physical activity should be encouraged as part of treatment for adults with depressive episode/disorder with inactive lifestyles. In moderate and severe depression, this intervention should be considered as adjunct to antidepressants or brief structured psychological treatments.
Q6: Is advice on physical activity better (more effective than/as safe as) than treatment as usual in adults with depressive episode/disorder with inactive lifestyles
Good practices in Mental Health and Well-being
SCOPING QUESTION: Which psychosocial interventions are effective in the management of cannabis dependence?
Country Progress Report
Reporting Period
January – December, 2014
Accessed: 26.09.2019
Assessment and Guidance for Strengthening Integration of Mental Health into Primary Health Care and Community-Based Service Platforms in Ukraine
Q1: Are brief psychosocial interventions for people using cannabis or psychostimulants effective in reducing drug use, dependence and harm from drug use?
SCOPING QUESTION:Which psychosocial interventions are effective in the treatment of psychostimulant dependence for adults and young people?
Occasional anxiety is a normal part
of life. You might worry about things
like health, money, or family
problems. But people with
generalized anxiety disorder (GAD)
feel extremely worried or feel
nervous about these and other
things—even when there is little or
no reason to worry about the...m.
People with GAD find it difficult to
control their anxiety and stay
focused on daily tasks.
The good news is that GAD is
treatable. Call your doctor to talk
about your symptoms so that you
can feel better.
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Do you sometimes have sudden attacks of
anxiety and overwhelming fear that last for
several minutes? Maybe your heart pounds,
you sweat, and you feel like you can’t
breathe or think. Do these attacks occur at
unpredictable times with no obvious trigger,
causing you to worry about the possibi...lity of
having another one at any time?
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Standard Treatment Guideline
As part of the Mental Health Gap Action Programme, WHO has developed training manuals (Training of trainers and supervisors training manual and Training of health-care providers training manual) to support implementation of the mhGAP Intervention Guide for mental, neurological and substance use (MNS...) disorders in non-specialized health settings, version 2.0. These manuals can be used to build capacity among non-specialist health-care providers in the assessment and management of people with priority MNS conditions in low resource settings.
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Retention of knowledge and application within the community one year later
املعالجة الرسيرية
لالضطرابات النفسية والعصبية واستخدام مواد اإلدمان
يف حاالت الطوارئ اإلنسانية
Mhgap Humanitarian Intervention Guide (mhGAP-HIG): Clinical management of mental, neurological and substance use cond...itions in humanitarian emergencies
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Q9: What is/are the effective and safe interventions to treat somatoform disorders in children and adolescents in non- specialist health settings?
An Evidence-Based Treatment Guide for Clinicians