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2015 Pipeline Report HIV, Hepatitis C virus (HCV), and Tuberculosis (TB)

Polly Clayden, Simon Collins, Mike Frick, et al. A. Benzacar; HIV i-BASETREATMENT ACTION GROUP (2015)
Drugs, Diagnostics, Vaccines, Preventive Technologies, Research toward a cure, and immune-based and gene therapies in development
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Target Regimen Profiles for TB Treatment

World Health Organization WHO (2016) C_WHO
There is an urgent need for safer, simpler, more efficacious and accessible treatment regimens for all forms of TB. The development of Target Product Profiles for TB treatment regimens (referred to as Target Regimen Profiles or TRPs) seeks to guide the drug development process towards important regi... more
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Guidelines for use of Bedaquiline in RNTCP through conditional access under Programmatic Management of Drug Resistant Tuberculosis in India (Part 2)

World Health Organization (WHO), Central TB Division Ministry of Health and Family Welfare, Government of India (2016) C_WHO
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Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis (CDC)

Centers for Diseases Control and Prevention (2019) C_CDC
National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention Division of Tuberculosis Elimination Accessed: 08.10.2019
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Community-Based Care for Drug-Resistant Tuberculosis: A Guide for Implementers

United States Agency for International Development (USAID) (2011)
This guide provides practical, step-by-step guidance on how to organize, implement, and monitor community-based care for DR TB. It is equally useful for program planning or supervision. The target audience for this guide is TB Program Managers, governments, policy makers, nongovernmental organizatio... more
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PIH Guide to the Medical Management of MDR-TB

USAID; TB Care; DRTB Training Network (2014) C1
This guide is a resource for physicians and other health care professionals who provide care and treatment to patients with drug-resistant tuberculosis.
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WHO treatment guidelines for isoniazid-resistant tuberculosis: Supplement to the WHO treatment guidelines for drug-resistant tuberculosis
recommended

World Health Organization WHO (2018) C_WHO
The new WHO recommendations for the treatment of isoniazid-resistant, rifampicin-susceptible TB are based upon a review of evidence from patients treated with such regimens by a Guideline Development Group in conformity with WHO requirements for evidence-based policies.
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Management of MDR-TB: A field guide

Partners in Health, World Health Organization (2009) C_WHO
Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) increasingly occur in resource-constrained settings. In the context of a national response to MDR- and XDR-TB, health workers in TB clinics (in district hospitals and some accredited health centres) wil... more
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MDR-TB Weight-Based Dosing Chart for Children

Sentinel Project (2013) C1
Therapy for MDR-TB is extremely long, complex and burdensome to both patients and health care systems. A single diagnosis can require two years of treatment, or longer. When treating children, there are significant additional barriers treating children with MDR-TB. There is limited data on the pharm... more
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Active tuberculosis drug-safety monitoring and management (aDSM)

World Health Organization (2015) C_WHO
Framework for implementation. The END TB Strategy.
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Management of drug-resistant tuberculosis

World Health Organization (2014) C_WHO
Training for staff working at DR-TB management centres. Training modules
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Framework for the engagement of all health care providers in the management of drug resistant tuberculosis

World Health Organization (2015) C_WHO
The END TB strategy
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Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis

Centers for Disease Control and Prevention, National Center for HIVAIDS, et. al (2013) C_CDC
National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention. Division of Tuberculosis Elimination.
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Drug-resistant tuberculosis: how to interpret rapid molecular test results

World Health Organisation (2020) C_WHO
This training toolkit by the European Laboratory Initiative for TB, HIV and Viral Hepatitis provides a unique combination of practical guidance and expert advice on the interpretation of selected WHO-endorsed tests for drug-resistant tuberculosis (DR-TB).
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Meeting report of the WHO expert consultation on the definition of extensively drug-resistant tuberculosis

World Health Organization WHO (2021) CC
Meeting Report 27-29 October 2020 The overall goal of the meeting was to discuss recent changes in treatment regimens and diagnostics for drug-resistant TB and to determine how these impact on the definition of XDR-TB, with a view to revising this definition. The pre-existing definition of XDR-TB w... more
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WHO consolidated guidelines on tuberculosis: module 4: treatment: drug-resistant tuberculosis treatment,update

World Health Organization WHO (2022) C_WHO
These guidelines group all recommendations on TB care and support in one document and are complemented by an operational handbook. The guidelines are to be used primarily by national TB programmes, or their equivalents in Ministries of Health, stakeholders and technical organizations working on... more
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Rapid Communication: Key changes to the treatment of drug-resistant tuberculosis
recommended

World Health Organization WHO (2022) C_WHO
These updates include shorter novel 6-month all-oral regimens for the treatment of multidrug- and rifampicin-resistant TB (MDR/RR-TB), with or without additional resistance to fluoroquinolones (pre-XDR-TB) as well as an alternative 9-month all-oral regimen for the treatment of MDR/RR-TB. This Ra... more
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Factsheet: Drug-Resistant Tuberculosis in the Americas

Pan American Health Organisation PAHO (2021) C_WHO
12 countries have a high TB estimated burden with an incidence rate more than 45 per 100 000 population They represent 88 of the cases in the Region In 2019 the TB case detection gap in the Region was 52 500 cases
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Investing in drug-resistant tuberculosis household contact management and preventive treatment

Hussain.H.; Malik, A. A. The Lancet (2022) CC
Preventing tuberculosis infection from progressing to tuberculosis disease is a crucial component of the goal to eliminate tuberculosis. When deciding on the use of tuberculosis preventive therapy among household contacts, policy makers regularly ask questions, such as whether tuberculosis preventiv... more
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The use of next-generation sequencing for the surveillance of drug-resistant tuberculosis: an implementation manual

World Health Organisation (WHO) (2023) C_WHO
This document provides practical guidance on planning and implementing next-generation sequencing (NGS) technology for characterization of Mycobacterium tuberculosis complex (MTBC) bacteria. The aim is to detect mutations associated with drug resistance in the context of a surveillance system for tu... more