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Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the
...
severity of the infection, therapeutic options are limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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Guia de treinamento para profissionais de saúde da linha de frente
Versão oficial em português da obra original em Inglês
Recognizing neglected tropical diseases through changes on the skin: a training guide for front-line health workers
Humanitarian NGOs have made increased use of Private Security Providers (PSPs) over the last decade. There is a gap between the ways that NGOs actually use PSPs and the regulation of this engagement. These guidelines aim to assist humanitarian NGOs
...
in reaching an informed decision about when, how and under what conditions to seek PSP services. The guidelines are aimed at operational managers of NGOs, from headquarter to field level. The guidelines do not only cover armed guarding or armed protection, but can be applied to the wide range of services provided by PSPs. Document also available in French.
more
Operational guidance for managing programme quality.
These guidelines are about implementing the programme-quality standards of the Core Humanitarian Standard in limited access humanitarian response. They have been developed using approaches and to
...
ols tested by Oxfam, other INGOs and the UN in Afghanistan, DRC, Iraq, Somalia, Syria and Yemen. The guidelines are an operational resource to help programme designers and decision makers deliver ‘good enough’ programme quality in limited access humanitarian response.
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This publication provides managers with guidance on how to create basic HIV prevention cascades as a starting point to enhance their ability to monitor and improve their programming and to facilitat
...
e comparisons of programme effectiveness across sites.
more
South Africa reported it fist case of COVID-19 on 5 March 2020. While the first cases were imported, local transmission has led to a rapid increase in the number of cases. As of 21 April 2020, more than 3,400 cases and 58 deaths had been confirmed.
...
On 15 March, President Cyril Ramaphosa declared a national state of disaster, and the government has since taken several measures to curb the spread of the virus, including closing borders, implementing strict social distancing measures and a 35-day nation-wide lockdown. These measures, along with the global economic shock caused by the pandemic, are expected to generate rising needs requiring an immediate and urgent response. Although South Africa is considered an upper-middle-income country, the amount of disparities—social, economic, and gender—make the country particularly vulnerable during this emergency.
more
The equation is simple: we cannot effectively respond to a global pandemic when millions of people are still caught in warzones. We cannot treat sick people when hospitals are being bombed, or prevent the spread of coronavirus when tens of millions are forced to flee from violence. We must have a gl
...
obal ceasefire, and we must put our collective resources behind making that ceasefire a reality.
more
This guide has been produced by the International
Network on Explosive Weapons (INEW) to introduce the
humanitarian advocacy agenda on the use of explosive
weapons in populated areas and to provide ideas for actions
at the national level. It
...
is aimed primarily at NGOs and
campaigners working on humanitarian issues and issues
related to weapons and protection of civilians.
more
The present report is submitted pursuant to Security Council resolution 2164 (2014), by which the Council extended the mandate of the United Nations Multidimensional Integrated Stabilization Mission in Mali (MINUSMA) and requested me to report to it
...
every three months on the implementation of the resolution and the progress on the implementation of the Mission’s mandate. The present report covers the period from 17 December 2014 to 19 March 2015.
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Fills a gap in current guidance on how to implement humanitarian standards in urban situations. In Arabic, English, French and Spanish available
สื่อ “สาร” ให้เข้าถึง : คู่มือนักข่าวส าหรับการรายงานเกี่ยวกับการเปลี่ยนแปลงสภาพภูมิอากาศและการพัฒนาอย่า
...
งยั่งยืนในภูมิภาคเอเชียและแปซิฟิก
A new, free handbook, for journalists reporting climate change in Asia and the Pacific
It explores the essential aspects of climate change, including its injustices to vulnerable communities, especially women and girls and least developed countries, and provides examples of best practices and stories of hope unique to the region. It can be used as a resource for journalists to understand the science of climate change, as well as helping journalists to improve their reporting of the environmental, social, economic, political, technological and other angles of the story.
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This is the third guidance note in a four-part series of notes related to impact evaluation developed by InterAction with financial support from the Rockefeller Foundation.This third guidance note, Introduction to Mixed Methods in Impact Evaluation, starts by explaining what a mixed methods (MM) imp
...
act evaluation design is and what distinguishes this approach from quantitative or qualitative impact evaluation designs. It notes that a mixed methods approach seeks to integrate social science disciplines with predominantly quantitative (QUANT) and predominantly qualitative (QUAL) approaches to theory, data collection, data analysis and interpretation. The guidance note is also available in French and Spanish on https://www.interaction.org/impact-evaluation-notes. ATTENTION: ANNEXES 1 TO 11 TO THIS DOCUMENT CAN BE FOUND IN ENGLISH VERSION ON: https://www.interaction.org/introduction-mixed-methods-impact-evaluation-annexes
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Apostolic Exhortation Evangelii Gaudium of the Holy Father Francis to the Bishops, Clergy, Consecrated Persons and the lay faithul on the proclamation of the gospel in the today`s world
In the last quarter of 2019 Southern African Regional Interagency Standing Committee Africa (RIASCO) reported that more than 11 million people were experiencing crisis or emergency levels of food insecurity in nine Southern African countries1 due to deepening drought
...
and climate related crisis. The Southern African Development Community (SADC) urged for urgent humanitarian action, and at the beginning of November 2019 Angola, Botswana, Lesotho and Namibia had declared states of drought emergencies, requiring international assistance to address the worsening food insecurity situation.
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This case study examines the humanitarian response to the conflict-related crisis in the North-East of Nigeria, focusing primarily on the period from 2015 to the end of 2016. The aim is test the central hypotheses of the Emergency Gap project: that the current structure, conceptual underpinning
...
and prevalent mindset of the international humanitarian system limits its capacity to be effective in response to conflict-related emergencies.
As with many conflict-related crises, the emergency in north-east Nigeria has deep and complex roots in the history of the region. The conflict began in 2009 and quickly developed beyond the control of the authorities. It unfolded in the midst of pre-existing political, social and economic tensions, making an effective humanitarian response exceedingly difficult. Despite this complexity, what is clear is that the crisis has resulted in a sprawling humanitarian disaster that has killed over 25,000 people as a direct result of the violence, and continues to devastate many more lives through hunger, psychological trauma and lack of access to healthcare. more
As with many conflict-related crises, the emergency in north-east Nigeria has deep and complex roots in the history of the region. The conflict began in 2009 and quickly developed beyond the control of the authorities. It unfolded in the midst of pre-existing political, social and economic tensions, making an effective humanitarian response exceedingly difficult. Despite this complexity, what is clear is that the crisis has resulted in a sprawling humanitarian disaster that has killed over 25,000 people as a direct result of the violence, and continues to devastate many more lives through hunger, psychological trauma and lack of access to healthcare. more
Distributing immediate, lifesaving assistance is one of the most urgent actions in an emergency response and can significantly improve the safety and wellbeing of individuals. Non-Food Items (NFI
...
), Food Security, WASH and Shelter in-kind assistance actors can help reduce and mitigate protection risks to individuals and communities when conducting distributions.
more
A Communities Report on Progress Towards the UN Political Declaration on the Fight Against TB and a Call to Action to Close the Gaps in TB Targets
This report documents how - – two years on from the United Nations High-Level Meeting on TB
...
and the Political Declaration on the Fight Against Tuberculosis – there is a major gap between the targets endorsed by heads of state and governments, and the results achieved. This is felt most acutely within communities, where it results in deaths and suffering. A Deadly Divide is informed by extensive inputs from TB-affected communities and civil society throughout the world. It presents evidence and experiences for six key Areas for Action.
Available in Arabic, English, French, Russian, Spanish, Portuguese
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This note provides information and practical guidance to support gender-based violence (GBV) practitioners to integrate attention to disability into GBV prevention, risk mitigation and response effo
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rts during the COVID-19 pandemic. This document complements other resources relating to GBV and COVID-19 and assumes that the user is already familiar with common GBV prevention, risk mitigation and response approaches.
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El documento WHO Guidance on community mental health services: Promoción de enfoques centrados en la persona y basados en los derechos humanos forma parte del conjunto de publicaciones de la OMS Orientación y paquetes técnicos sobre servicios com
...
unitarios de salud mental. Ofrece una descripción detallada de los enfoques de salud mental centrados en la persona y basados en los derechos humanos, así como ejemplos resumidos de servicios de buenas prácticas en todo el mundo. Describe los vínculos necesarios con los sectores de la vivienda, la educación, el empleo y la protección social, y presenta ejemplos de redes regionales y nacionales integradas de servicios comunitarios de salud mental. Se presentan recomendaciones específicas y pasos de acción para desarrollar servicios de salud mental comunitarios que respeten los derechos humanos y se centren en la recuperación. Este exhaustivo documento va acompañado de un conjunto de siete paquetes técnicos centrados en categorías específicas de servicios de salud mental y de orientaciones para la creación de nuevos servicios.
Orientaciones de la OMS sobre los servicios comunitarios de salud mental: Promover enfoques centrados en la persona y basados en los derechos es un conjunto de publicaciones que proporciona información y apoyo a todas las partes interesadas que deseen desarrollar o transformar su sistema y servicios de salud mental para que se ajusten a las normas internacionales de derechos humanos, incluida la Convención de las Naciones Unidas sobre los Derechos de las Personas con Discapacidad.
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On November 9, the Russian military announced a full retreat of all their forces from the right bank of Dnipro River; by November 11, 41 settlements, including Kherson city, were de-occupied by Ukrainian forces. Civilians who live in these areas have endured months of combat
...
and occupation. Services have been interrupted or severely disrupted due to damage or destruction of facilities and infrastructure through combat actions, looting of the majority of the valuable assets by the retreating Russian troops, and dispersion of the people rendering said services.
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