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Treatments and vaccines for COVID-19

European Medicines Agency EMA (2021) CC

The European Medicines Agency (EMA) is evaluating potential COVID-19 treatments and vaccines to enable promising medicines to reach patients as soon as possible. It is also interacting with medicine developers and making use of real-world data to monitor the safety and effectiveness of medicines use... more

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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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A Field Guide to Antibiotic Stewardship in Outpatient Settings

Telligen, Quality Innovation Network National Coordinating Center, Centers for Medicare & Medicaid Services (CMS) (2018) C2

Antibiotic Stewardship (AS) is a coordinated program that promotes the appropriate use of antimicrobials to improve patient outcomes, reduce microbial resistance, and decrease the spread of multi-drug resistant organisms. In clinical settings, stewardship activities focus on measuring and improving ... more

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Corticosteroids for COVID-19

World Health Organization WHO (2020) C_WHO

WHO published guidance for clinicians and health care decision-makers on the use of corticosteroids in patients with COVID-19. We recommend systemic corticosteroids for the treatment of patients with severe and critical COVID-19. We suggest not to use corticosteroids in the treatment of patients ... more

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Behavorial Health Departement - Primary Care Center and fireweed Treatment Guidelines for PTSD

Sorkin, J., Chaney, G., Garcia, M.,et al. (2006) C2

This treatment guideline is intended to assist clinicians in the Behavioral Health department in treatment planning and service delivery for patients with Post Traumatic Stress Disorder (PTSD). It may also assist clinicians treating patients who have some of the signs and symptoms of PTSD but who do... more

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IPC guidelines for ambulances transferring known or suspected COVID-19 cases
recommended

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C1

These guidelines outline the minimum operational guidance for infection prevention and control (IPC) in ambulances transferring suspected or confirmed COVID-19 patients. Ambulance staff should be trained in the procedures outlined here as part of their induction and prior to starting work. They are ... more

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The public health implications of asthma

Bousquet, J.; Bousquet, P.; Godard, P.; Daures, J. (2005) CC2

Health economics is receiving more attention as decisionmakers — including purchasers, physicians and patients seek a more comprehensive understanding of the impact of adopting new health care strategies in developed and developing countries. Formal economic evaluation is playing an increasingly i... more

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HIV Management in Russia

V. Allan Ipsos; The Global Virology Therapy Monitor Team, Ipsos Healthcare (2013) C2

Examining the infrastructure of the Russian and USA healthcare systems with respect to the management of HIV patients

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Developing, Implementing, and Monitoring the Use of Standard Treatment Guidelines: A SIAPS How-To Manual

Systems for Improved Access to Pharmaceuticals and Services (SIAPS) MSH, USAID (2015) CC

STGs are designed to assist health care professionals in making decisions about appropriate, effective patient care. However, health managers often have trouble setting and meeting the high standards required of modern, developed health care systems. With stakeholders expressing concern over issues ... more

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Making Health Care Safer – Antibiotic Rx in Hospitals: Proceed with Caution

Centers for Disease Control and Prevention CDC (2019) C_CDC

Antibiotics save lives, but poor prescribing practices are putting patients at unnecessary risk for preventable allergic reactions, super-resistant infections, and deadly diarrhea. Errors in prescribing decisions also contribute to antibiotic resistance, making these drugs less likely to work in th... more

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View PDF (2001)

Policy Guidelines for Collaborative TB and HIV Services for Injecting and Other Drug Users: An Integrated Approach

World Health Organization, UNAIDS, United Nations Office on Drugs and Crime (2008)

These policy guidelines provide a strategic approach and new recommendations for integrated TB and HIV services for patients suffering from substance-abuse addiction. The key recommendations fall under three main categories: joint planning, key interventions, and overcoming barriers.

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Guidelines for the management of asthma in adults and adolescents: Position statement of the South African Thoracic Society – 2021 update

Lalloo, U.G.; Kalla, I.S.; Abdool-Gaffar, S. et al. African Journal of Thoracic and Critical Care Medicine (2021) CC

sthma prevalence is increasing worldwide, and surveys indicate that most patients in developed and developing countries, including South Africa, do not receive optimal care and are therefore not well controlled. Standard management guidelines adapted to in-country realities are important to support ... more

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WHO guidelines on the use of chest imaging in COVID-19
recommended

World Health Organization WHO (2022) C_WHO

Updated 2022. This guide addresses the care pathway from presentation of the patient to a health facility to patient discharge. It considers different levels of disease severity, from asymptomatic individuals to critically ill patients. Accounting for variations in the benefits and harms of chest im... more

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Major trauma backpack 2021

World Health Organization WHO (2021) C_WHO

The WHO Trauma Bag 2021 is intended to provide the resources needed to care for care of acutely ill and injured patients in hospital emergency units, field hospitals or clinics providing acute care. The Trauma Bag may also be applicable in prehospital settings if care is provided by advanced practi... more

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Testing Algorithm Zika Infection

Bernhard Nocht Institute for Tropical Medicine (2016) C1

When is laboratory testing for Zika Virus infection reasonable? Testing algorithm for patients with and without symptoms.

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Cancer Education Materials

Global Oncology (2024) C2

Website last accessed on 16.03.2024 GO developed our Cancer Education Materials (CEM) tool to improve the patient diagnosis and treatment experience in resource-limited settings, reduce stigma, help facilitate dialogue between patients and providers, and ensure that no patient stops treatment beca... more

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Global Competency-Based Fistula Surgery Training Manual

FIGO and Partners; UNFPA (2011)

Too few physicians are equipped with the knowledge and skills needed to repair genital fistulae and care for patients following surgery. Most procedures are performed in Africa and Asia by local physicians, with technical support from surgeons from developed countries where these fistulae are rarely... more

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Ebola: What Every Health Care Professional Should Know

University of Alabama at Birmingham (UAB) School of Nursing (2014)

The course has an emphasis on health care in the US: "health care professionals need to understand this virus as more patients in the United States are confirmed to have EVD and patients are being transported to the US for treatment". Does anyone know of similar online courses (in English and/or Fre... more

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Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases
recommended

World Health Organization WHO (2020) C_WHO

The purpose of this document is to provide interim guidance to laboratories and stakeholders involved in laboratory testing of patients who meet the definition of suspected case of pneumonia associated with a novel coronavirus identified in Wuhan, China. 19 March 2020

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Cholera Information for health workers

World Health Organization WHO; Eastern Mediterranean Region (2022) C_WHO

The poster provides information for medical personnel. It includes recommendations for the treatment of cholera patients and guidelines for hygiene measures.

IPC guidelines for ambulances transferring known or suspected COVID-19 cases recommended

WHO guidelines on the use of chest imaging in COVID-19 recommended

Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases recommended

IPC guidelines for ambulances transferring known or suspected COVID-19 cases
recommended

WHO guidelines on the use of chest imaging in COVID-19
recommended

Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases
recommended