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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Ensuring health security in the African region: Emergency preparedness and response flagships progress report #4

World Health Organisation (WHO) (2022) C_WHO

The World Health Organization Regional Office for Africa (WHO AFRO), in accordance with recommendations from various WHO committees, has developed three flagship initiatives to support Member States in the African region to prepare for, detect and respond to public health emergencies. They are the r... more

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Palliative care for older people: better practices

Hall, S.; H. Petkova, A.D. Tsouros, et al. World Health Organization WHO, Regional Office for Europe, et al. (2011) C_WHO

This publication aims to provide examples of better palliative care practices for older people to help those involved in planning and supporting care-oriented services most appropriately and effectively. Examples have been identifi ed from literature searches and from an international call... more

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Safety in administering medicines for neglected tropical diseases
recommended

World Health Organization WHO (2021) C_WHO

This manual summarizes key issues related to the safety of NTD medicines and their administration, with a focus on essential medicines used in mass drug administration (MDA), also called preventive chemotherapy. It can be used as a standalone reference manual, but is intended to be used in conjuncti... more

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WORLD HEART REPORT 2023 CONFRONTING THE WORLD’S NUMBER ONE KILLER

Cesare, M.D.; Bixby, H.; Gaziano, T. et al. World Heart Federation (2023) CC

Global progress against cardiovascular disease (CVD) is flatlining. Though rates of CVD deaths globally have fallen in the last three decades, this trend has begun to stall and, without concerted efforts, is at risk of reversing.

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Responding to COVID-19 in Africa: using data to find a balance part II

African Union, African CDC, World Health Organisation (2020) C_WHO

Six months in, the indirect impacts of COVID-19 take a toll on health, social and economic outcomes.

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Cancer
recommended

Hellen Gelband,Jha Prabhat, Rengaswamy Sankaranarayanan et al. The World Bank (2015) C1

This volume presents the complex patterns of cancer incidence and death around the world and evidence on effective and cost-effective ways to control cancers. The Disease Control Priorities Volume 3 evaluation of cancer will indicate where cancer treatment is ineffective and wasteful, and offer alte... more

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Creating HIV prevention cascades — Operational guidance on a tool for monitoring programmes

UNAIDS (2021) C_WHO

This publication provides managers with guidance on how to create basic HIV prevention cascades as a starting point to enhance their ability to monitor and improve their programming and to facilitate comparisons of programme effectiveness across sites.

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A new approach to cholera in Haiti: Report by the Secretary-General (A/71/895)

UN General Assembly (2017) C1

On 19 August 2016, the former UN Secretary-General announced a new approach to cholera in Haiti, consisting of two tracks. Track 1 focuses on reducing cholera transmission, improving access to care, and addressing water, sanitation, and health system issues. Track 2 aims to provide material assistan... more

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OSCE human dimension commitments and state responses to the COVID-19 pandemic

Organization for Security and Co-operation in Europe OSCE (2020) CC

The COVID-19 pandemic has been a formative experience for all humanity and a health emergency of global proportions, presenting a huge challenge to national leaders, health systems, and citizens. The findings of a new report by the OSCE Office for Democratic Institutions and Human Rights (ODIHR) sho... more

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Operational handbook on tuberculosis: module 6: tuberculosis and co-morbidities, 3rd ed

World Health Organization WHO (2025) C_WHO

Addressing comorbidities and risk factors for tuberculosis (TB) is a crucial component of the World Health Organization (WHO)’s End TB Strategy. This WHO operational handbook on tuberculosis. Module 6: tuberculosis and comorbidities aims to support countries in scaling up people-centred care, base... more

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Nutrition Program Design Assistant: A Tool for Program Planners (NPDA)

CORE Group Nutrition Working Group, Food and Nutrition Technical Assistance III Project (FANTA), and Save the Children (2015)

Reference Guide Version 2. Revised. The Nutrition Program Design Assistant is a tool to help organizations design the nutrition component of their community-based maternal and child health, food security, or other development program. The tool focuses on prevention and also provides guidance on recu... more

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Antimicrobial stewardship: changing risk-related behaviours in the general population

National Institut for Health and Care Excellence NICE (2017) C2

This guideline covers making people aware of how to correctly use antimicrobial medicines (including antibiotics) and the dangers associated with their overuse and misuse. It also includesmeasures to prevent and control infection that can stop people needing antimicrobials or spreadinginfection to o... more

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Community based Mental health and Psychosocial support in humanitarian settings: Three-tiered support for children and families (Field test)

UN Children's Fund UNICEF (2018) CC

The CB MHPSS operational guidelines were developed in response to emerging evidence on the determinants of children’s resilience, lessons learned from the evaluation of existing approaches, and the unique challenges that today’s crises pose for children’s safety, wellbeing and optimal developm... more

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The Planetary Health Education Framework

Guzman C., Potter T. (2020) CC

The Planetary Health Education Framework is a project of the Planetary Health Alliance (planetaryhealthalliance.org). The Planetary Health Alliance is a consortium of over 250 partners from around the world committed to understanding and addressing the human health impacts of global environmental ch... more

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Diabetes in the South-East Asia Region

World Health Organization (WHO), Regional Office for South-East Asia (2016) C_WHO

Special issue: WHO South-East Asia Journal of Public Health -Vol. 5, Issue 1, April 2016.This special This issue contains a rich collection of articles, demonstrating the encouraging scientific momentum to address the growing burden of diabetes in the region

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Primary Protection: Enhancing Health Care Resilience for a Changing Climate

Robin G. and J. Balbus (2014) CC

Best Practices Report.PART 1 Primary Protection: Enhancing Health Care Resilience for a Changing Climatei Primary Protection: EnhancingU.S. Department of Health and Human Services

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HIV & AIDS, Gender, and Domestic Violence

Brot für die Welt; DIFÄM (2010) C2

The first chapter provides an overview of gender and domestic violence in the HIV and AIDS discourse and their interconnect- edness. It analyses literature regarding gender and HIV transmission, domestic violence, and HIV and AIDS. It then discusses how gender roles impact the effects of AIDS. The... more

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2023 حالة أطفال العالم لعام

UN Children's Fund UNICEF (2024) CC

The article focuses on "The State of the World’s Children 2023" report published by UNICEF. It highlights the critical role of vaccines in saving lives and the challenges in global immunization efforts, especially for marginalized and underserved children. The report emphasizes the impact of COVID... more

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Finding community-led solutions to COVID-19
recommended

RCCE technical working group (2020) C1

An interagency guidance note on working with communities in high density settings to plan local approaches to preventing and managing COVID-19. This guidance note is intended for anyone involved in COVID-19 risk communication and community engagement (RCCE) efforts in complex and fragile settings in... more

Safety in administering medicines for neglected tropical diseases recommended

Cancer recommended

Finding community-led solutions to COVID-19 recommended

Safety in administering medicines for neglected tropical diseases
recommended

Cancer
recommended

Finding community-led solutions to COVID-19
recommended