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Publication Years
1066
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Despite a historical association with poor tolerability, a comprehensive review on safety of antileishmanial chemotherapies is lacking. We carried out an update of a previous systematic review of all published clinical trials in visceral leishmaniasis (VL) from 1980 to 2019 to document any reported
...
serious adverse events (SAEs).
more
Risk factors for asthma among schoolchildren who participated in a casecontrol study in urban Uganda
Data on asthma aetiology in Africa are scarce. We investigated the risk factors for asthma among schoolchildren (5–17 years) in urban Uganda. We conducted a case-control study, among 555 cases and 1115 controls. Asthma was diagnosed by study clinicians. The main risk factors for asthma were tertia
...
ry education for fathers (adjusted OR (95% CI); 2.32 (1.71–3.16)) and mothers (1.85 (1.38–2.48)); area of residence at birth, with children born in a small town or in the city having an increased asthma risk compared to schoolchildren born in rural areas (2.16 (1.60–2.92)) and (2.79 (1.79–4.35)), respectively; father’s and mother’s history of asthma; children’s own allergic conditions; atopy; and cooking on gas/electricity. In conclusion, asthma was associated with a strong rural-town-city risk gradient, higher parental socio-economic status and urbanicity. This work provides the basis for future studies to identify specific environmental/lifestyle factors responsible for increasing asthma risk among children in urban areas in LMICs.
more
Accessed November 2017
Paying for performance (P4P) provides financial incentives for providers to increase the use and quality of care. P4P can affect health care by providing incentives for providers to put more effort into specific activities, and by increasing the amount of resources available to finance the delivery
...
of services. This paper evaluates the impact of P4P on the use and quality of prenatal, institutional delivery, and child preventive care using data produced from a prospective quasi-experimental evaluation nested into the national rollout of P4P in Rwanda. Treatment facilities were enrolled in the P4P scheme in 2006 and comparison facilities were enrolled two years later. The incentive effect is isolated from the resource effect by increasing comparison facilities’ input-based budgets by the average P4P payments to the treatment facilities. The data were collected from 166 facilities and a random sample of 2158 households. P4P had a large and significant positive impact on institutional deliveries and preventive care visits by young children, and improved quality of prenatal care. The authors find no effect on the number of prenatal care visits or on immunization rates. P4P had the greatest effect on those services that had the highest payment rates and needed the lowest provider effort. P4P financial performance incentives can improve both the use of and the quality of health services. Because the analysis isolates the incentive effect from the resource effect in P4P, the results indicate that an equal amount of financial resources without the incentives would not have achieved the same gain in outcomes.
more
Patients with retreatment tuberculosis (TB) represent those
who have been treated previously for onemonth ormorewith
anti-TB drugs and who have been diagnosed once again with
the disease.These patientsmainly include relapses, treatment
after failure, or loss to follow-up on a first-line treatmen
...
t
regimen [1]. The number of these patients is not negligible.
In 2014, of the 6.3 million TB cases that were notified
by National TB Programmes (NTPs) to the World Health
Organization (WHO), approximately 700,000 patients were
already previously treated
more
A summary of what we know
The articles in this compendium elaborate on some of the ideas shared at the symposium. Together, they provide a broad view of the dynamic interactions among physical, sexual and brain development that take place during adolescence. They highlight some of the risks to optimal development – includi
...
ng toxic stress, which can interfere with the formation of brain connections, and other vulnerabilities unique to the onset of puberty and independence. They also point to the opportunities for developing interventions that can build on earlier investments in child development – consolidating gains and even offsetting the effects of deficits and traumas experienced earlier in childhood.
more
Climate Change 2021: The Physical Science Basis. Contribution of Working Group I to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change
The Lancet. Published Online December 22, 2016 http://dx.doi.org/10.1016/S0140-6736(16)32621-6. Open Access
Climate Change 2021: The Physical Science Basis. Contribution of Working Group I to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change
The report surveyed 9 leading bilateral and multilateral education donors in respect of their approach to disability-inclusive education.
Психическое здоровье детей и подростков в Российской Федерации в 2000–2012 годах
Е.В. Макушкин, Н.К. Демчева, Н.А. Творогова
ФГБУ «Государственный научный центр социальной и судебной психиатрии им. В.П. Сербского» Минздрава России
(2013)
C1
На основе эпидемиологического исследования за период 2000–2012 годов выявлены высокие показатели общей и первичной заболеваемости детского и подросткового населен
...
я в Российской Федерации и по всем федеральным округам. Установлено увеличение числа инвалидов среди детей и подростков при снижении коечных мест и тенденции сокращения числа детских и подростковых психиатров в психиатрических службах субъектов. Сложившаяся ситуация требует дальнейшего пересмотра подходов к оказанию психиатрической помощи несовершеннолетним лицам. Необходимо избежать сокращения объемов психиатрических ресурсов. Однако комплекс организационных мероприятий немыслим без адекватного финансового обеспечения территориальных программ оказания психиатрической помощи, в том числе на основании выполнения Программы государственных гарантий
бесплатного оказания гражданам медицинской помощи и выделения субсидий на диспансеризацию,
лечение и профилактику.
more
The pre-clinical pipeline shows more innovation and diversity, with 252 agents being developed to treat WHO priority pathogens.
However, these products are in the very early stages of development and still need to be proven effective and safe. The optimistic scenario, the report indicates, is for
...
the first two to five products to become available in about 10 years.
more
12 February 2021
Climate Change 2021: The Physical Science Basis. Contribution of Working Group I to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change
Open Journal of Psychiatry, 2014, 4, 390-395
Published Online October 2014 in SciRes. http://www.scirp.org/journal/ojpsych
http://dx.doi.org/10.4236/ojpsych.2014.44045
Цель: оценить этиологическую структуру симптоматической эпилепсии, возрастную структуру периода манифестации заболевания, среднюю длительность латентного пери
...
да среди детей с различным характером повреждений, зависимость частоты приступов от характера повреждения. Материал и методы. Изучались 180 медицинских карт пациентов, имевших симптоматическую и криптогенную формы заболевания. Анализ заключался в оценке анамнестических данных, параметров ЭЭГ-исследований и нейровизуализации. Результаты. Установлено преобладание гипоксически-ишемической энцефалопатии в этиологической структуре заболевания. Возраст манифестации чаще приходился на период от года до 3 лет. Наиболее частой локализаци-
ей эпилептогенного очага явилась область височной и лобной доли. Наиболее длительный латентный период отмечен при ЧМТ, а наиболее короткий — при нейроинфекциях и последствиях внутриутробных инфекций. Заключение. Симптоматическая эпилепсия у детей является многофакторным заболеванием, течение и проявление которого в значительной мере зависят от инициального повреждения, вызвавшего данную патологию.
http://www.ssmj.ru/system/files/2014_02_318-319.pdf
more
La thèse de Yobouet Inès Kouakou, soutenue à l’Université Claude Bernard Lyon 1, porte sur le traitement d’urgence du paludisme sévère chez l’enfant à l’aide d’une administration intranasale d’artésunate. L’objectif principal de ce travail est d’explorer, in vitro, la voie na
...
sale comme alternative à la voie intra-rectale recommandée actuellement en pré-hospitalier. L’étude démontre la non-toxicité de formulations d’artésunate sur un modèle de muqueuse nasale humaine, bien que la perméation observée reste faible. Des pistes sont proposées pour améliorer cette perméation, notamment par l’optimisation galénique. La thèse inclut également une revue de la pharmacocinétique de l’artésunate et le développement de méthodes de dosage simples et peu coûteuses, adaptées aux laboratoires à ressources limitées. Ce travail s’inscrit dans une démarche de lutte contre le paludisme, notamment en zones rurales où l’accès aux soins reste difficile.
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