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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Protect the promise: 2022 progress report on the every woman every child global strategy for women’s, children’s and adolescents’ health (2016–2030)

World Health Organisation (WHO) (2022) C_WHO

This global progress report attempts to lay the groundwork for the kind of accelerated action needed. Section 1 presents key data, trends and developments in women’s, children’s and adolescents’ health and well-being. That is followed in Section 2 by a deeper dive into the impact of the COVID-... more

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Responding to COVID-19 in Africa: using data to find a balance part III

African Union, African CDC, World Health Organisation (2021) C_WHO

12 May 2021. This third survey in the series shows that the COVID-19 pandemic continues to impact societies, not only in terms of health, but also social and economic conditions and day-to-day life

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Climate change and communicable diseases: a manual for health workers

World Health Organization. Regional Office for Europe (2011) C_WHO

There is a broad consensus nowadays that the Earth is warming up as a result of greenhouse gas emissions caused by anthropogenic activities. It is also clear that current trends in the fields of energy, development and population growth will lead to continuous and ever more dramatic climate change. ... more

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Antimicrobial Resistance: Challenges and Perspectives

Doyle, M.P.; G. H. Loneragan, H. M. Scott et al. (2006) C2

Comprehensive Reviews in Food Science and Food Safety, Vol.12 (2013) pp.234-248 In 2006, the Institute of Food Technologists (IFT) published an Expert Report entitled “Antimicrobial Resistance: Implications for the Food System” (IFT 2006). That report summarized current scientiﬁc knowledge pe... more

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Biodiversity & Infectious Diseases - Questions & Answers

Convention on Biological Diversity (2020) C2

Infectious diseases cause over one billion human infections per year, with millions of deaths each year globally. Extensive health and financial burden is seen from both established and emerging infectious diseases. Infectious diseases also affect plants and animals, which may pose threats to agricu... more

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Protocol for Enhanced Isolate-Level Antimicrobial Resistance Surveillance in the Americas. Primary Phase: Bloodstream Infections

Pan American Health Organisation PAHO (2021) C_WHO

Antimicrobial resistance (AMR) surveillance plays an important role in the early detection of resistant strains of public health importance and prompt response to outbreaks in hospitals and the community. Surveillance findings are needed to inform medical practice, antibiotic stewardship, and policy... more

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Managing epidemics
recommended

World Health Organization WHO (2018) C_WHO

Key facts about major deadly diseases.This manual provides concise and up-to-date knowledge on 15 infectious diseases that have the potential to become international threats, and tips on how to respond to each of them. You can download an interactive version directly at the website http://www.who.... more

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International Health Regulations (2005) and chemical events

World Health Organization (2015) C_WHO

In 2005, the World Health Organization (WHO) Member States adopted the revised International Health Regulations (IHR) (2005). The Regulations provide a unique public health framework in the form of obligations and recommendations that enable countries to better p... more

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Rohingya Refugee Crisis Response Plan - Monitoring Report 25

Inter Sector Coordination Group (ISCG) (2017) C1

The Monitoring Report, which covers the first two months of the response from 25 August to 31 October, highlights the work of the Government of Bangladesh, in cooperation with humanitarian partners who are working to provide relief services for the refugee population and Bangladeshi host communities... more

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Climate-Smart Healthcare : Low-Carbon and Resilience Strategies for the Health Sector

The World Bank Group (2017) CC

Climate change is damaging human health now and is projected to have a greater impact in the future. Low- and middle-income countries are seeing the worst effects as they are most vulnerable to climate shifts and least able to adapt given weak health systems and poor infrastructure. Low-carbon appro... more

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Sick Development

Anna Marriott Oxfam International (2023) CC

Development finance institutions owned by European governments and the World Bank Group are spending hundreds of millions of dollars on expensive for-profit hospitals in the Global South that block patients from getting care, or bankrupt them, with some even imprisoning patients who cannot afford th... more

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G7 Shared Understanding on Enhanced Finance-Health Coordination and PPR Financing

G7 (2023) CC

The COVID-19 pandemic has had unprecedented public health, economic, and social impacts on the international community, and prompted an unprecedented range and size of policy actions globally. Collective efforts, at national, regional, and global levels, were called for to contain and mitigate such ... more

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IDF Diabetes Atlas 2021

International Diabetes Federation IDF (2022) C1

10th edition The IDF Diabetes Atlas 10th edition provides detailed information on the estimated and projected prevalence of diabetes, globally, by region, country and territory, for 2021, 2030 and 2045. It draws attention to the growing impact of diabetes across the world and highlights proven and ... more

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IRC Health Strategy 2023-2027

International Rescue Committee (2023) CC

The International Rescue Committee (IRC) is a leading humanitarian agency dedicated to helping people whose lives have been shattered by conflict and disaster to survive, recover, and gain control of their future. Health comprises nearly half of IRC’s program portfolio globally and encompasses thr... more

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Global report on health data systems and capacity, 2020
recommended

World Health Organization WHO (2021) C_WHO

31 Janaury 2021 SCORE for health data technical package. The first global assessment on the status and capacity of health information systems in 133 countries, covering 87% of the global population. It identifies gaps and provides guidance for investment in areas that can have the greatest impact ... more

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Healthy environments for healthy children

World Health Organization (WHO) (2010) C_WHO

This booklet presents key messages for action, summarized from a set of chapters on different environmental health issues, available at www.who.int/ ceh/publications/healthyenvironmentsforhealthychildren. The work is a result of an on-going partnership between WHO, UNEP and UNICEF in the area of chi... more

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Climate change and Human Health : risks and responses

World Health Organization (WHO) (2003) CC

Over the ages, human societies have altered local ecosystems and modified regional climates. Today the human influence has attained a global scale. This reflects the recent rapid increase in population size, energy consumption, intensity of land use, international trade and travel, and other human a... more

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Towards disability - inclusive education

Saeboenes, A.-M.; et al. Expert Group on Disability (2015) CC

Background paper for the Oslo Summit on Education for Development. This paper covers the four topics of the Oslo Summit: investment in education, quality of learning, education in emergencies and girls’ education. Disability continues to be one of the primary causes of educational disadvantage a... more

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Climate Change and Health: Local Solutions to Local Challenges

Paul J. Schramm, Munerah Ahmed, Hannah Siegel, Jamie Donatuto et al. (2020) CC

Current Environmental Health Reports volume 7, pages 363–370 (2020) Climate change has direct impacts on human health, but those impacts vary widely by location. Local health impacts depend on a large number of factors including specific regional climate impacts, demographics and human vulnerabil... more

Managing epidemics recommended

Global report on health data systems and capacity, 2020 recommended

Managing epidemics
recommended

Global report on health data systems and capacity, 2020
recommended