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A role for nuclear techniques
Antimicrobials play a critical role in the treatment of human and animal (aquatic and terrestrial) diseases, which has led to their widespread application and use. Antimicrobial resistance (AMR) is the ability of micro
...
organisms to stop an antibiotic, such as an antimicrobial, antiviral or antimalarial, from working against them. Globally, about 700 000 deaths per year arise from resistant infections as a result of the fact that antimicrobial drugs have become less effective at killing resistant pathogens. Antimicrobial chemicals that are present in environmental compartments can trigger the development of AMR. These chemicals can also cause antibiotic-resistant bacteria (ARB) to further spread antibiotic resistance genes (ARG) because they may have an evolutionary advantage over non-resistant bacteria.
more
In aquaculture, antibiotics have been used mainly for therapeutic purposes and as prophylactic agents. The contribution to antimicrobial resistance of antibiotics used in aquaculture is reviewed here, using a risk analysis framework. Some recommenda
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tions on responsible conduct in this context are proposed, aimed at diminishing the threat of build up of antimicrobial resistance.
more
Veterinarians are leaders and stewards in preserving the effectiveness of antibiotics for animals and people. Working with animal owners and producers, veterinarians can slow antibiotic resistance by implementing disease prevention strategies and im
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proving the use of antibiotics while also guaranteeing high-quality medical care for animal patients.
more
The global tripartite self-assessment survey of country progress in addressing antimicrobial resistance (AMR) is a component of a broader approach for monitoring and evaluation of the global action plan on AMR. This report analyses the results of th
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e second tripartite self-assessment survey
more
The ability of bacteria to resist the action of an antibiotic has become a recognised global problem. Antibiotic resistance severely limits the number of antibiotics available for the treatment of diseases.
Scientists have known for more than half a century that patients could develop resistance to the drugs used to treat them. Alexander Fleming, who is credited with creating the first antibiotic, penicillin, in 1928, cautioned of the impending crisis
...
while accepting his Nobel prize in 1945: “There is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant.” Since then antibiotics have proved one of the most effective interventions in human medicine. Sadly, the overuse and misuse of this precious resource have brought us to a global crisis of antimicrobial resistance (AMR). To address this crisis nearly seven decades after Fleming’s lecture the first UN general assembly meeting on drug resistance bacteria was convened in September 2017.
more
Antibiotics save lives, but poor prescribing practices are putting patients at unnecessary risk for preventable allergic reactions,
super-resistant infections, and deadly diarrhea. Errors in prescribing decisions also contribute to antibiotic resistance
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, making these drugs less likely to work in the future.
more
The National Action Plan for Combating Antibiotic-Resistant Bacteria (CARB), 2020-2025, presents
coordinated, strategic actions that the United States Government will take in the next five years to improve the health and wellbeing of all Americans by changing the course of antibiotic
...
resistance.
This Plan is based on the U.S. Government’s 2014 National Strategy for CARB, and builds on the first National Action Plan released in 2015 by expanding evidence-based activities that have already been shown to reduce antibiotic resistance, such as optimizing the use of antibiotics in human and animal health settings.
more
Tunisie Plan National de Lutte contre l'Antibioresistance 2019-2023
République Tunienne - Ministére de la santé
Food and Agriculture Organization of the United Nations FAO and World Health Organization WHO
(2019)
C_WHO
L'antibiorèsistance constitue actuellment un problème de santè puplique en Tunisie. En effet, depuis une quinzaine d'anneés, notre pays fait face á un accroissment global des rèsistances bactériennes aux agents antimicrobiens. Ce phénoméne qui concerne également la majorité des pays, est
...
dû á l'apparition et l'extension de nouveaux mécanismes de résistance, rendant inefficaces les traitements actuellment disponibles.
République Tunienne - Ministére de la santé
more
Tanzania: The National Action Plan on AMR 2017-2022
The United Republic of Tanzania - Ministry of Health Community Development Gender Elderly and Children
World Health Organization WHO
(2017)
C_WHO
This National Action Plan addresses actions needed to be taken in order to combat antimicrobial resistance (AMR) in the country. It is obligatory to raise awareness of antimicrobial resistance and p
...
romote behavioral change through public communication
programmes that targets human, animal and plant health. Inclusion of the use of antimicrobial agents and resistance in school curricula will further promote better understanding and awareness from an early age. Antimicrobial Resistance knowledge, surveillance and research will be strengthened through establishing a national surveillance system for antimicrobial resistance, establishing and building capacity for a national reference laboratory and designated laboratories for AMR surveillance, developing a national research agenda on AMR and establishing and supporting a coordinated mechanism that will ensure harmonized AMR guidelines, data management and sharing systems in human, animal and plant health settings.
more
This action plan for the Kingdom Saudi Arabia to combat antimicrobial resistance has been formulated in the line of the WHO five objectives. It addresses the need for effective “one health” approach involving coordination among numerous national
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sectors and actors, including human and veterinary medicine, agriculture, finance, environment, and well-informed consumers. Therefore, a large committee of all stakeholders was formed with five technical subcommittees were established to addresses every aspect
to contain antimicrobial resistance in the country.
more
Antimicrobial agents play an indispensable role in animal health and welfare management. At the same time, the need for prudent use is obvious to ensure good food safety outcomes and to manage the potential risk of antimicrobial resistance. The emer
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gence of multi-resistant bacteria is posing challenges to health professionals and communities around the world for both human and animal health. These bacteria are not destroyed by the common antimicrobial agents and so pose a risk to people, particularly children, the elderly and those with poorly functioning immune systems, as well as to animals.
Throughout the years, the dairy sector has been very much aware of the need for responsible use and has, in many countries, implemented adequate measures throughout the dairy supply chain.
more
This document is intended for use by state and local health departments and healthcare facilities and serves as general guidance for the initial response for the containment of novel or targeted multidrug-resistant organisms (MDROs) or resistance me
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chanisms. It is not intended to describe all the actions that might be required for control of an outbreak (e.g., sustained transmission within a facility or region). In addition, further evaluation might be required based on the findings of the initial response described in this document.
more
This guideline covers making people aware of how to correctly use antimicrobial medicines (including antibiotics) and the dangers associated with their overuse and misuse. It also includesmeasures to prevent and control infection that can stop people needing antimicrobials or spreadinginfection to o
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thers. It aims to change people's behaviour to reduce antimicrobial resistance and thespread of resistant microbes.
more
AWaRe – a new WHO tool to help countries improve antibiotic treatment, increase access and reduce resistance. We can reduce or even reverse antibiotic resistance by using antibiotics more responsi
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bly. But how do we do that and still ensure that patients are treated effectively?WHO has developed a tool to help global, regional and national decision-making on which antibiotics to use when. The tool indexes the most effective antibiotics into three groups – ACCESS, WATCH, RESERVE (AWaRe for short). Evidence shows that to optimize use of antibiotics and reduce resistance, countries should increase the proportion of ACCESS antibiotics to correspond to at least 60% of total national consumption.
more
Antibiotic Stewardship (AS) is a coordinated program that promotes the appropriate use of antimicrobials to improve patient outcomes, reduce microbial resistance, and decrease the spread of multi-drug resistant organisms. In clinical settings, stewa
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rdship activities focus on measuring and improving how antibiotics are prescribed by clinicians and used by patients. Improving antibiotic prescribing involves implementing effective strategies to modify prescribing practices to align them with evidence-based recommendations for diagnosis and management.
more
Nepal has only recently started its journey on the path to an integrated response to the challenge of antimicrobial resistance (AMR). Despite this, it is notable that the Nepal Health Sector Strategy Plan (HSSP)-2 mentions growing antibiotic resista
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nceas a public health challenge.
more
The WHO CIA List should be used as a reference to help formulate and prioritize risk assessment and risk management strategies for containing antimicrobial resistance. The WHO CIA List supports strategies to mitigate the human
...
health risks associated with antimicrobial use in food-producing animals and has been used by both public and private sector organizations. The list helps regulators and stakeholders know which types of antimicrobials used in animals present potentially higher risks to human populations and how use of antimicrobials might be managed to minimize antimicrobial resistance of medical importance. The use of the WHO CIA List, in conjunction with the OIE list of antimicrobials of veterinary importance (1) and the WHO Model Lists of Essential Medicines (2) , will allow for prioritization of risk management strategies in the human sector, the food animal sector, inagriculture (crops) and horticulture, through a coordinated multisectoral One Health approach.
more
WHO CIA list categorizes all antimicrobials used in human medicine into 3 groups based on their importance to human medicine. The current scope is limited to antibacterial drugs of which most are also used in veterinary medicine. The list assists in man
...
aging antimicrobial resistance, ensuring that all, especially critically important antimicrobials, are used prudently both in human and veterinary medicine
more
La liste CIA de l’OMS catégorise tous les antimicrobiens utilisés en médecine humaine en 3 groupes, selon leur importance pour la médecine humaine. Elle se limite actuellement aux médicaments antibactériens, dont la plupart sont également employés en médecine vété
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rinaire.Cette liste est destinée à aider à la gestion de la résistance bactérienne, en veillant à ce que l’ensemble des antimicrobiens, surtout ceux d’importance critique, sont utilisés prudemment aussi bien en médecine humaine qu’en médecine vétérinaire.
more
