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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Тестування на туберкульозну інфекцію та скринінг на туберкульоз серед біженців, які прибувають до країн Європи з України

European Centre for Disease Prevention and Control ECDC (2022) C1

7 April 2022. Aimed at national policymakers, public health and healthcare planners, staff working in reception centres, and healthcare staff caring for displaced persons, the information note concludes that universal testing of incoming refugees from Ukraine for tuberculosis (TB) infection is not r... more

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Considerations for the use of face masks in the community in the context of the SARS-CoV-2 Omicron variant of concern

European Centre for Disease Prevention and Control ECDC (2022) CC

Wearing a face mask can help reduce the spread of COVID-19 in the community by reducing the release of respiratory droplets from asymptomatic / pre-symptomatic individuals or those with mild non-specific symptoms. The use of face masks for this purpose may be adopted to reduce the societal impact as... more

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Monitoring and Evaluation of COVID-19 Rapid Antigen Diagnostic Test Rollout in Africa
recommended

African Union; Africa CDC Centres for Disease Control and Prevention (2021) C1

Limited coverage of laboratory services and long turnaround times from real-time reverse transcription-polymerase chain reaction (rRT-PCR) for the detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been insufficient to meet the demands in many African countries in response... more

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Antibiotic resistance: How does antibiotic resistance spread?

European Centre for Disease Prevention and Control (2014) C2

Antibiotic resistance is a natural occurrence caused by mutations in bacteria’s genes. However, inappropriate use of antibiotics accelerates the emergence and spread of antibiotic-resistant bacteria. When exposed to antibiotics, susceptible bacteria are killed; while excessive antibiotic use or th... more

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A guide for surveillance of antimicrobial resistance in leprosy: 2017 update
recommended

E. A. Cooreman WHO SEARODepartment of Control of Neglected Tropical Diseases (2017) C_WHO

In case of resistance to rifampicin, fluoroquinolones become the preferred category of second-line drugs. Unfortunately, quinolone-resistant strains of Mycobacterium leprae have also been reported in several countries, probably due to the extensive use of quinolones for treating several types of inf... more

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African Union Framework for Antimicrobial Resistance Control 2020–2025
recommended

African Union; Africa CDC Centres for Disease Control and Prevention; World Health Organization WHO, et al. (2021) CC

Reports of antimicrobial-resistant (AMR) microorganisms are increasing globally, threatening to render existing treatments ineffective against many infectious diseases. In Africa, AMR has already been documented to be a problem for human immunodeficiency virus (HIV) and the pathogens that cause mala... more

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Africa CDC World Antimicrobial Awareness Week 2020 Resources and Social media Toolkit

African Union; Africa CDC Centres for Disease Control and Prevention (2020) CC

Such as antibiotics, antivirals, antiparasitics, and antifungals are important for infectious disease control in humans, animals and plants, but they can only continue to be effective if we use them responsibly and according to professional advice. Available in English, French and Portuguese

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Action Protocol for Enhanced SARI and ILI Surveillance for COVID-19 in Africa (Arabic)

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C2

March 2020 The number of African Union Member States reporting COVID- 19 cases is increasing and there is a likelihood of community transmission. The WHO recently modified the COVID-19 suspect case definition to include severe acute respiratory infection and advises testing of all severe acute r... more

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Guidance on Setting Up an Isolation Ward for COVID-19 Cases (Arabic Version)
recommended

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C1

إرشاداتٌ حول إنشاء عنابر العزل الخاصة بالحالات المصابة بفيروس كورونا المستجد This document simplifies the WHO guidance on severe acute respiratory infection (SARI) treatment centres and is meant to be accessible to healthcare work... more

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Interim guidance on COVID-19 Rapid Antigen self-testing to African Union Member States

African Union; Africa CDC Centres for Disease Control and Prevention (2022) C1

This guidance addresses rationale, risk-based scenarios, practical considerations prior to adoption of the self-testing products, quality assurance, safety and ethical considerations, and data management considerations for COVID-19 self-testing. The Africa CDC recommends the use of rapid antigen sel... more

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West Africa - Ebola Outbreak, Fact Sheet #39, Fiscal Year (FY) 2015 (as of July 14, 2015)

US Agency for International Development, Centers for Disease Control and Prevention (2015)

The Government of Liberia (GoL) reports three additional EVD cases linked to the Margibi County cluster, including one in Liberia’s Montserrado County; new confirmed case total reaches six Recently extended Operation Northern Push strengthens contact tracing and EVD prevention activities ... more

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Covid-19 Test to Treat Guidelines
recommended

African Union; Africa CDC Centres for Disease Control and Prevention (2022) C1

n response to the outbreak, the Africa Centres for Disease Control and Prevention (Africa CDC) has been supporting African Union Member States in responding to the COVID-19 pandemic through a variety of interventions such as non-pharmaceutical interventions, quarantine, testing, isolation, contact t... more

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Non-conventional humanitarian interventions on Ebola outbreak crisis in West Africa

Tambo, Ernest (2014)

Infectious Diseases of Poverty 2014, 3:42 http://www.idpjournal.com/content/3/1/42

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Child protection emergency preparedness and response guidance to the COVID-19

UNICEF East Asia and Pacific Region (2020) C_UNICEF

Infectious diseases, such as COVID-19, can have a significant impact on children’s and their caregivers’ wellbeing beyond the disease itself. In terms of child protection, there are three main potential secondary impacts: - Neglect and lack of parental care. - Mental health and Psychosocia... more

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Technical Note: Protection of Children during the Coronavirus Pandemic (v.2)

The Alliance for Child Protection in humanitarian action (2020) C2

Infectious diseases like COVID-19 can disrupt the environments in which children grow and develop. Disruptions to families, friendships, daily routines and the wider community can have negative consequences for children’s well-being, development and protection. In addition, measures used to preven... more

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Falling aid for reproductive, maternal, newborn and child health in the lead-up to the COVID-19 pandemic

Pitt, C.; Bath, D.; Binyaruka, P.; Borghi, J.; Martinez-Alvarez, M. BMJ Global Health (2021) CC

Infectious disease epidemics pose a threat to reproductive, maternal, newborn and child health (RMNCH) both directly—by worsening women’s and children’s health outcomes—and indirectly—by reducing their access to services.1–4 Greater investment is therefore needed to mitigate the negative... more

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Nodding syndrome

Scott F. Dowell, James J. Sejvar, Lul Riek, et al. CDC (2013) CC

Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 19, No. 9, September 2013

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Technical update on treatment optimization: use of efavirenz during pregnancy: a public health perspective

World Health Organization (2012) C_WHO

1.HIV infections – drug therapy. 2.Anti-HIV agents – adverse effects. 3.Anti-retroviral agents. 4.Benzoxazines – adverse effects. 5.Pregnancy. 6.Disease transmission, Vertical - prevention and control. 7.Treatment outcome. I.World Health Organization

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Situation Analysis Antibiotic Use and Resistance in India

Public Health Foundation India (2011) C2

The infectious disease burden in India is among the highest in the world. A large amount of antibiot-ics are consumed in fighting infections, some of them saving lives, but every use adding to antibiotic resistance in bacteria. Antibiotic use is increasing steadily (table 1), particularly ... more

Monitoring and Evaluation of COVID-19 Rapid Antigen Diagnostic Test Rollout in Africa recommended

A guide for surveillance of antimicrobial resistance in leprosy: 2017 update recommended

African Union Framework for Antimicrobial Resistance Control 2020–2025 recommended

Guidance on Setting Up an Isolation Ward for COVID-19 Cases (Arabic Version) recommended

Covid-19 Test to Treat Guidelines recommended

Monitoring and Evaluation of COVID-19 Rapid Antigen Diagnostic Test Rollout in Africa
recommended

A guide for surveillance of antimicrobial resistance in leprosy: 2017 update
recommended

African Union Framework for Antimicrobial Resistance Control 2020–2025
recommended

Guidance on Setting Up an Isolation Ward for COVID-19 Cases (Arabic Version)
recommended

Covid-19 Test to Treat Guidelines
recommended