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The cardiovascular disease continuum begins with risk factors such as diabetes mellitus (DM), progresses to vasculopathy and myocardial dysfunction, and finally ends with cardiovascular death. Diabetes is associated with a 2- to 4-fold increased risk for heart failure (HF). Moreover, HF patients wit
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h DM have a worse prognosis than those without DM. Diabetes can cause myocardial ischemia via micro- and macrovasculopathy and can directly exert deleterious effects on the myocardium. Hyperglycemia, hyperinsulinemia, and insulin resistance can cause alterations in vascular homeostasis. Then, reduced nitric oxide and increased reactive oxygen species levels favor inflammation leading to atherothrombotic progression and myocardial dysfunction. The classification, diagnosis, and treatment of HF for a patient with and without DM remain the same. Until now, drugs targeting neurohumoral and metabolic pathways improved mortality and morbidity in HF with reduced ejection fraction (HFrEF). Therefore, all HFrEF patients should receive guideline-directed medical therapy. By contrast, drugs modulating neurohumoral activity did not improve survival in HF with preserved ejection fraction (HFpEF) patients. Trials investigating whether sodium-glucose cotransporter-2 inhibitors are effective in HFpEF are on-going. This review will summarize the epidemiology, pathophysiology, and treatment of HF in diabetes.
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Стратегия народосбережения в Российской Федерации — один из основных документов государственной социальной политики. Она может быть реализована различными путя
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ми, в частности увеличением продолжительности жизни представителей старшего поколения. Анализ концепций старения и гендерных особенностей процесса старения, дискурс-анализ практики формирования социального и психического здоровья женщин старшего поколения позволили выделить типологию основных социальных проблем этой возрастной группы.
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Malawi Internationally recommended key policies uptake
Country Profile
Le Tchad reste confronté à un cycle récurrent de crises alimentaires et nutritionnelles ayant un impact négatif sur la santé et l’état nutritionnel des populations en général et celle des personnes les plus vulnérables que sont les enfants, les femmes enceintes et/ou allaitantes et les pe
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rsonnes âgées en particulier.
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This publication discusses official development assistance (ODA) provided by the USA with a focus on health, HIV/AIDS, tuberculosis and malaria. It also reflects upon ODA by the USA in comparison to other donors and funding targets.
The "Regional Action Plan 2017–2030: Towards a Malaria-Free South-East Asia Region" by the World Health Organization (WHO) outlines a strategic framework to eliminate malaria in the 11 countries of the WHO South-East Asia Region by 2030. It focuses on reducing transmission, particularly of Plasmod
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ium falciparum and P. vivax, addressing multidrug resistance, improving surveillance, and ensuring universal access to diagnosis, treatment, and prevention. The plan sets clear objectives and milestones and emphasizes strong governance, cross-border collaboration, community involvement, and sustainable financing to achieve and maintain a malaria-free status across the region.
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Tanzania has an estimated 2.9 million adults with diabetes, 35% of whom are undiagnosed, and over 22,000 people living with type 1 diabetes. While the 2023 Universal Health Insurance law aims to improve access to care, only 15% of people are insured. Over 700 clinics provide diabetes care and offer
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free insulin to children and young adults. However, challenges remain regarding insulin availability, diagnostics, patient education and the healthcare workforce. Community engagement, training and policy advocacy are essential for improving diabetes management and achieving universal health coverage.
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This guide aims to provide an overview of successful practice from the field for the disaster risk reduction/management practitioner interested in EWS. It presents guiding principles that will build a strong foundation for the design or strengthening of EWS at any level. It is not an operational, bu
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t a strategic, guide that insists on asking the right questions and exploring all perspectives prior even to deciding whether or not early warning is the appropriate tool for a given context.
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Rights of employees who are HIV-positive. HIV-positive employees will be protected against discrimination, victimisation or harassment
Strategic information and analytics report No 1, published 17 April 2025. 75 out of 106
surveyed countries reported disruptions in at least one essential health service area.
Guidelines for the Prevention and Treatment of Opportunistic Infections in Children With and Exposed to HIV
recommended
Full Guidelines
Dosing Recommendations for Prevention and Treatment
IAS–USA Topics in Antiviral Medicine. September 22, 2025
Safe Motherhood Series
Managers Who Lead empowers health managers at all levels of an organization to lead teams to face challenges and achieve results. It answers questions such as: How can I lead and manage more effectively? How do I create a shared vision and a clear path for achieving it? What can I do to improve work
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climate? How can I prepare myself and others for higher levels of responsibility? How do I lead change inside and outside my organization?
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to identify measure and decide how to meet the humanitarian needs of disaster-affected community
Practical Pharmacy for Developing Countries No.22
Aarti Patel, Patrick Mubangizi, Christa Cepuch
Ecumenical Pharmaceutical Network (EPN); HAI Africa
(2010)
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