PNAS 119 (8) e2113947119 | https://doi.org/10.1073/pnas.2113947119
Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, m...easure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world’s rivers, representing the environmental influence of 471.4 million people across 137 geographic regions. Samples were obtained from 1,052 locations in 104 countries (representing all continents and 36 countries not previously studied for API contamination) and analyzed for 61 APIs. Highest cumulative API concentrations were observed in sub-Saharan Africa, south Asia, and South America. The most contaminated sites were in low- to middle-income countries and were associated with areas with poor wastewater and waste management infrastructure and pharmaceutical manufacturing. The most frequently detected APIs were carbamazepine, metformin, and caffeine (a compound also arising from lifestyle use), which were detected at over half of the sites monitored. Concentrations of at least one API at 25.7% of the sampling sites were greater than concentrations considered safe for aquatic organisms, or which are of concern in terms of selection for antimicrobial resistance. Therefore, pharmaceutical pollution poses a global threat to environmental and human health, as well as to delivery of the United Nations Sustainable Development Goals.
more
A view of global supply chains, pressure points, and implications for antimicrobial resistance response
An interdisciplinary study within the framework of the dialogue project on the contribution of the Catholic Church to a socio-ecological transformation.
The study examines the obstacles to the implementation of the socio-ecological transformation and develops recommendations for action.
Europe and Central Asia Economic Update.
The Russian Federation’s war with Ukraine has triggered a catastrophic humanitarian crisis and threatened the stability of geopolitical relations. Economic output in the Europe and Central Asia region is forecast to contract by more than 4.1% in 2022—the... second major shock and regional recession in two years. Moreover, the war has added to mounting concerns of a sharp global growth slowdown.
more
Ambio 51, 9-12 (2022). This article belongs to Ambio’s 50th Anniversary Collection. Theme: Solutions-oriented research.
Inferences through Machine Learning.Background Report.
What are the major origins and drivers of different types of conflict? Sorting out the main
causes of conflict and war is difficult and often shaped by ideological believes. Even today,
historians and political scientists have discussions on... the primary causes of the First World
War. There are several types of conflict, ranging from international and civil wars to local
conflicts, riots and revolution. And there are many theories that explain these different types
of conflict, which mostly focus on economic conditions and a range of factors that can foster
grievances and greed, creating incentives to initiate or join a conflict
more
7 April 2022. Aimed at national policymakers, public health and healthcare planners, staff working in reception centres, and healthcare staff caring for displaced persons, the information note concludes that universal testing of incoming refugees from Ukraine for tuberculosis (TB) infection is not r...ecommended. Specific groups, such as household contacts of bacteriologically confirmed pulmonary cases, or those who are immunocompromised should however be considered for TB infection testing.
Available in Czech, Hungarian, Polish, Romanian, Slovakian, Ukranian
more
The Lancet Regional Health - Americas 2022;00: 100248 Published online xxx https://doi.org/10.1016/j.lana.2022.100248.
The Lancet Countdown report, discuss the overlapping social, climate and health challenges in Latin America and the Caribbean, and urge multisectoral and political action to trans...form these challenges into opportunities through adaptation and mitigation measures that place peoples’ health and wellbeing at the centre of public policies. Latin American and Caribbean governments are called upon to promote climate-resilient health care systems with adaptation plans that are tailored to guarantee quality access to care for all in this viewpoint.
more
Dengue is a mosquito-borne viral disease that occurs mainly in the tropics and subtropics but has a high potential to spread to new areas. Dengue infections are climate sensitive, so it is important to better understand how changing climate factors affect the potential for geographic spread and futu...re dengue epidemics. Vectorial capacity (VC) describes a vector's propensity to transmit dengue taking into account human, virus, and vector interactions. VC is highly temperature dependent, but most dengue models only take mean temperature values into account. Recent evidence shows that diurnal temperature range (DTR) plays an important role in influencing the behavior of the primary dengue vector Aedes aegypti. In this study, we used relative VC to estimate dengue epidemic potential (DEP) based on the temperature and DTR dependence of the parameters of A. aegypti. We found a strong temperature dependence of DEP; it peaked at a mean temperature of 29.3°C when DTR was 0°C and at 20°C when DTR was 20°C. Increasing average temperatures up to 29°C led to an increased DEP, but temperatures above 29°C reduced DEP. In tropical areas where the mean temperatures are close to 29°C, a small DTR increased DEP while a large DTR reduced it. In cold to temperate or extremely hot climates where the mean temperatures are far from 29°C, increasing DTR was associated with increasing DEP. Incorporating these findings using historical and predicted temperature and DTR over a two hundred year period (1901-2099), we found an increasing trend of global DEP in temperate regions. Small increases in DEP were observed over the last 100 years and large increases are expected by the end of this century in temperate Northern Hemisphere regions using climate change projections. These findings illustrate the importance of including DTR when mapping DEP based on VC.
more
Journal of Land Use Science, 16:3, 223-239, DOI: 10.1080/1747423X.2021.1933226
This European compendium was produced to provide operational examples of the new nursing and midwifery roles and new service delivery models currently being employed across the Region. The case studies directly relate to the priority areas in Health 2020 and exemplify the types of activities needed ...to fully implement the objectives within the Strategic Directions framework.
more
The Kigali Declaration on neglected tropical diseases (NTDs) is a high-level, political declaration which aims to mobilise political will and secure commitments to achieve the Sustainable Development Goal 3 (SDG3) target on NTDs and to deliver the targets set out in the World Health Organization’s... Neglected Tropical Disease Roadmap (2021-2030).
Available in English, French, Spanish, Portuguese, German, Kiswahli, Chinese,
more
Briefing Note no. 80 November 2015
Transformation and outlook
The Lab identifies, develops, and launches sustainable finance
instruments that can drive billions to a low-carbon economy. The
2019 Global Lab Cycle targets four specific sectors across
mitigation and adaptation: blue carbon in marine & coastal
ecosystems; sustainable agriculture for smallholde...rs in West and
Central Africa; sustainable energy access; and sustainable cities
more