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Vitamin Deficiency and Tuberculosis: Need for Urgent Clinical Trial for Managment of Tuberculosis

S. Chakraborty, K. Syal, R. Bhattacharyya, et al. (2014) CC
Review Article: Journal of Nutritional Health & Food Science Vitamin Deficiency and Tuberculosis: Need for Urgent Clinical Page 1- 6
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BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial

M. A. Gasper, A. C. Hesseling, I. Mohar, et al. JCI insight (2017) C2
Clinical Medicine JCI Insight. 2017;2(7):e91963.
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Antidepressant drugs and generic counselling for treatment of major depression in primary care: randomised trial with patient preference arms

C. Chilvers, M. Dewey, K. Fielding, et al. (2001) CC
BMJ 2001;322:1–5
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Guidelines for Good Clinical Practice (GCP) for Trials on Pharmaceutical Products Bangladesh

Directorate General of Drug Administration,, Ministry of Health and Family Welfare, People's Republic of Bangladesh (2015) C1
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Sierra Leone: Guidelines for Conducting Clinical Trials of Medicinal Products and Vaccines

Pharmacy Board Sierra Leone (2014) C1
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Ebola research and development landscape of clinical candidates and trials

World Health Organization (WHO) (2015) C_WHO
The report presents current information (updated to September 2015) on candidate vaccines, therapies and medical devices for Ebola and gives an overview of completed and on-going trials.
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Guideline for Application to conduct Clinical Trials in Liberia

Liberia Medicines and Health Products Regulatory Authority (LMHRA) (2014) C1
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Adherence interventions and outcomes of tuberculosis treatment: A systematic review and meta-analysis of trials and observational studies

Alipanah N, Jarlsberg L et al. (2018) CC
We systematically reviewed Medline as well as the references of published review articles for relevant studies of adherence to multidrug treatment of both drug-susceptible and drug-resistant TB through February 3, 2018. We included randomized controlled trials (RCTs) as well as prospective and retro... more
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Zambia: GUIDELINES ON REGULATING THE CONDUCT OF CLINICAL TRIAL IN HUMAN PARTICIPANTS

Zambia Medicines Regulatory Authority (ZAMRA) (2016) C2
First Edition
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Cognitive Training for Schizophrenia in Developing Countries: A Pilot Trial in Brazil (Clinical Study)

Pontes LM, Martins CB, Napolitano IC, Fonseca JR, Oliveira GM, Iso SM, Menezes AK, Vizzotto AD, di Sarno ES, Elkis H. Schizophrenia Research and Treatment (2013) CC
Cognitive deficits in schizophrenia can massively impact functionality and quality of life, furthering the importance of cognitive training. Despite the development of the field in Europe and in the United States, no programmes have been developed and tested in developing countries. Different cultur... more
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Involving male partners in maternity care in Burkina Faso: a randomized controlled trial

Daniele M.A., Ganaba R., Sarrassat S. et. al. Research (2018) C2
Bull World Health Organ 2018;96:450–461 | doi: http://dx.doi.org/10.2471/BLT.17.206466 The aim of our study was to determine whether an intervention designed to involve the male partners of pregnant women in Burkina Faso in facility-based maternity care influences care-seeking and healthy practi... more
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Africa CDC Consortium for COVID-19 Vaccine Clinical Trials (CONCVACT)

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C1
August 2020, The Africa Joint Continental Strategy for COVID-19 is underpinned by the need to limit transmission, prevent deaths and reduce associated harms. Participation by African nations in clinical trials is an essential step to ensure that sufficient data is generated on the safety and efficac... more
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WHO Sciene in 5 #13 - COVID-19 - Vaccine trials

World Health Organization WHO (2021) C_WHO
Learn what scientists look for in the different phases of a clinical trial for a vaccine. What does it mean when a vaccine trial is halted due to an adverse event? WHO’s Dr Kate O’Brien explains in Science in 5 this week
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Mobile Tuberculosis Treatment Support Tools to Increase Treatment Success in Patients with Tuberculosis in Argentina: Protocol for a Randomized Controlled Trial

Iribarren, S.; Milligan H., Goodwin K., et al. (2021) CC
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Routine sterile glove and instrument change at the time of abdominal wound closure to prevent surgical site infection (ChEETAh): a pragmatic, cluster-randomised trial in seven low-income and middle-in

NIHR Global Reserach Health Unit on Global Surgery (2022) CC
The Lancet Vol.400 (2022) p.17-67-1776. Published:October 31, 2022DOI:https://doi.org/10.1016/S0140-6736(22)01884-0. Surgical site infection (SSI) is the most common complication of surgery around the world: ChEETAh trial finds routinely changing gloves and instruments for wound closure could preve... more
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Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial

Pohlig G, Bernhard SC, Blum J, Burri C, Mpanya A, et al. PLOS Neclected Tropical Diseases (2016) CC
This was a Phase 3, multi-center, randomized, open-label, parallel-group, active control study where 273 male and female patients with first stage Trypanosoma brucei gambiense HAT were treated at six sites: one trypanosomiasis reference center in Angola, one hospital in South Sudan, and four hospita... more
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Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol

Ásbjörnsdóttir K.H., Ajjampur S.S.R., Anderson R.M. et al (2018) C2
Soil-transmitted helminths (STH) affect 1.45 billion people worldwide, and high intensity infections are associated with anemia, undernutrition and impaired cognition, particularly among children. Mathematical models suggest it may be possible to interrupt the transmission of STH in a community by e... more
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Training community healthcare workers on the use of information and communication technologies: a randomised controlled trial of traditional versus blended learning in Malawi, Africa

Nikolaos Mastellos, Tammy Tran, Kanika Dharmayat et al. BMC Medical Education (2018) CC
Despite the increasing uptake of information and communication technologies (ICT) within healthcare services across developing countries, community healthcare workers (CHWs) have limited knowledge to fully utilise computerised clinical systems and mobile apps. The ‘Introduction to Information and ... more
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A household-based community health worker programme for non-communicable disease, malnutrition, tuberculosis, HIV and maternal health: a stepped-wedge cluster randomised controlled trial in Neno Distr

Wroe, E.B.; Nhlema, B.; Dunbar, E.L. et al. BMJ Global Health (2021) CC
Background: Community health worker (CHW) programmes are a valuable component of primary care in resource-poor settings. The evidence supporting their effectiveness generally shows improvements in disease-specific outcomes relative to the absence of a CHW programme. In this study, we evaluated expan... more
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Home visits versus fixed-site care by community health workers and child survival: a cluster-randomized trial, Mali

World Health Organisation (WHO) (2024) C_WHO
Despite recent global declines, under-five mortality remains high in many of the poorest countries. Barriers to timely quality care, including user fees, distance to facilities and the availability of trained health workers and medical supplies, hinder progress in further reducing morbidity and m... more