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Diagnostic testing for Ebola and Marburg virus diseases: interim guidance, 20 December 2024

World Health Organization WHO (2024) C_WHO

- The goal of diagnostic testing for Ebola and Marburg virus diseases is to identify cases to provide timely and appropriate care and to stop disease transmission. - All individuals meeting the case definition for Ebola or Marburg virus diseases should be tested. - The recommended sample type ... more

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Practical manual on tuberculosis laboratory strengthening, 2022 update

World Health Organisation (WHO) (2023) C_WHO

The Practical manual on laboratory strengthening, 2022 update provides practical guidance on implementation of WHO recommendations and best practices for TB laboratory strengthening. It is an updated version of the GLI Practical Guide to Laboratory Strengthening published in 2017 and provides the la... more

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Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review

Wright J.E., Werkman M., Dunn J.C. et al Parasites and Vectors (2018) C2

Background: The human helminth infections include ascariasis, trichuriasis, hookworm infections, schistosomiasis, lymphatic filariasis (LF) and onchocerciasis. It is estimated that almost 2 billion people worldwide are infected with helminths. Whilst the WHO treatment guidelines for helminth infecti...ons are mostly aimed at controlling morbidity, there has been a recent shift with some countries moving towards goals of disease elimination through mass drug administration, especially for LF and onchocerciasis. However, as prevalence is driven lower, treating entire populations may no longer be the most efficient or cost-effective strategy. Instead, it may be beneficial to identify individuals or demographic groups who are persistently infected, often termed as being “predisposed” to infection, and target treatment at them. Methods: The authors searched Embase, MEDLINE, Global Health, and Web of Science for all English language, humanbased papers investigating predisposition to helminth infections published up to October 31st, 2017. The varying definitions used to describe predisposition, and the statistical tests used to determine its presence, are summarised. Evidence for predisposition is presented, stratified by helminth species, and risk factors for predisposition to infection are identified and discussed. Results: In total, 43 papers were identified, summarising results from 34 different studies in 23 countries. Consistent evidence of predisposition to infection with certain species of human helminth was identified. Children were regularly found to experience greater predisposition to Ascaris lumbricoides, Schistosoma mansoni and S. haematobium than adults. Females were found to be more predisposed to A. lumbricoides infection than were males. Household clustering of infection was identified for A. lumbricoides, T. trichiura and S. japonicum. Ascaris lumbricoides and T. trichiura also showed evidence of familial predisposition. Whilst strong evidence for predisposition to hookworm infection was identified, findings with regards to which groups were affected were considerably more varied than for other helminth species. Conclusion: This review has found consistent evidence of predisposition to heavy (and light) infection for certain human helminth species. However, further research is needed to identify reasons for the reported differences between demographic groups. Molecular epidemiological methods associated with whole genome sequencing to determine ‘who infects whom’ may shed more light on the factors generating predisposition. more

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Global genomic surveillance strategy for pathogens with pandemic and epidemic potential, 2022–2032

World Health Organization WHO (2022) C_WHO

The Strategy provides a high-level unifying framework to leverage existing capacities, address barriers and strengthen the use of genomic surveillance in the detection, monitoring and response to public health threats. Genomic surveillance is part of the broader surveillance and laboratory system, a... more

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Methods for the detection and identification of SARS-CoV-2 variants, March 2021

World Health Organization WHO, Regional Office of Europe (2021) C_WHO

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The role of antibiotic stewardship in limiting antibacterial resistance among hematology patients

Gyssens I. C., W. V. Kern, D. M. Livermore Haematologica (2013) C2

Haematologica has published European guidelines for empirical and targeted antibacterial therapy forfebrile neutropenic patients in the era of emerging resistance (ECIL-4). Indeed, collateral damage by broad-spectrum antibiotic therapy includes selection of multidrugresistant pathogens, and incr... more

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Guidance for surveillance of SARS-CoV-2 variants: Interim guidance, 9 August 2021
recommended

World Health Organization WHO (2021) CC

This document aims to describe a minimum set of surveillance activities recommended at the national level to detect and monitor the relative prevalence of SARS-CoV-2 variants and outline a set of activities for the characterization and assessment of risk posed by these variants. A set of indicators ... more

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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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WHO confirms Zika virus strain imported from the Americas to Cabo Verde

World Health Organization WHO (2016) C_WHO

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Virological analysis: no link between Ebola outbreaks in west Africa and Democratic Republic of Congo

World Health Organization (2014)

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Multidrug-resistant tuberculosis in migrants, multi-country cluster - third update, 13 April 2017

European Centre for Disease Prevention and Control (2017) C1

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Central African Republic: National Recovery and Peacebuilding Plan 2017-21

World bank group The World Bank (2017) CC

The Central African Republic is at a major turning point in its history. The country is just emerging from a very violent conflict, during which thousands of human lives were lost and one-third of the population was displaced. After a three-year transition, and with the support of the internationa... more

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Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern

World Health Organization WHO (2021) C_WHO

26 Nov. 2021

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Buruli ulcer : management of Mycobacterium ulcerans disease : a manual for health care providers
recommended

J. Buntine; Crofts, K. World Health Organization WHO (2001) CC

This manual is addressed to health care providers dealing with Mycobacterium ulcerans disease (Buruli ulcer). The manual aims to achieve a better understanding of the disease, its clinical presentation and its surgical management. The manual is aimed particularly at district health care providers. A... more

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Special Focus: Update on SARS-CoV-2 Variants of Interest and Variants of Concern

World Health Organization WHO (2022) C_WHO

Weekly epidemiological update on COVID-19, 28 September 2022

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WHO/Europe and ECDC Monkeypox Surveillance Bulletin
recommended

World Health Organization WHO, Regional Office of Europe; European Center for Disease Control ECDC (2022) C_WHO

Here you can find the latest reports

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Buruli ulcer : diagnosis of Mycobacterium ulcerans disease : a manual for health care providers

F. Portaels; Johnson, P.; Meyers, W. World Health Organization WHO (2001) CC

This manual is to assist health care providers and laboratory scientists to diagnose mycobacterium ulcerans disease (Buruli ulcer). The manual aims to achieve a better understanding of the clinical presentation and its diagnosis. The methods described are tailored to various levels of care and avail... more

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Руководство по эпидемиологическому надзору за вариантами SARS-CoV-2

World Health Organisation (WHO) (2021) C_WHO

Временные рекомендации 9 августа 2021 г. Цель данного документа - описать минимальный набор мероприятий по эпиднадзору, рекомендуемых на национальном уровне для вы�... more

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Геномное секвенирование SARS-CoV-2 для целей общественного здравоохранения

World Health Organization WHO (2021) C_WHO

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Genomic Surveillance for SARS-CoV-2 in India, Indian SARS-CoV-2 Genomics Consortium

Ministry of Health& Family Welfare, Goverment of India (2021) CC

15 July 2021

Guidance for surveillance of SARS-CoV-2 variants: Interim guidance, 9 August 2021 recommended

Buruli ulcer : management of Mycobacterium ulcerans disease : a manual for health care providers recommended

WHO/Europe and ECDC Monkeypox Surveillance Bulletin recommended

Guidance for surveillance of SARS-CoV-2 variants: Interim guidance, 9 August 2021
recommended

Buruli ulcer : management of Mycobacterium ulcerans disease : a manual for health care providers
recommended

WHO/Europe and ECDC Monkeypox Surveillance Bulletin
recommended