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1
The Strong Families Programme was developed and piloted in Afghanistan thanks to the generous support of the US-INL. To date, this programme has further been piloted in Central America
...
, Central and West Asia, East and West Africa thanks to the support of Sweden, France and the US
more
Gambiense human African trypanosomiasis is a deadly infectious disease affecting West and Central Afric
...
a, South Sudan and Uganda, and transmitted between humans by tsetse flies. The disease has caused several major epidemics, the latest one in the 1990s. Thanks to recent innovations such as rapid diagnostic tests for population screening, a single-dose oral treatment and a highly efficient vector control strategy, interruption of transmission of the causative parasite is now within reach. If indeed gHAT has an exclusively human reservoir, this could even result in eradication of the disease. Even if there were an animal reservoir, on the basis of epidemiological data, it plays a limited role. Maintaining adequate postelimination surveillance in known historic foci, using the newly developed tools, should be sufficient to prevent any future resurgence.
more
Human African trypanosomiasis is caused by Trypanosoma brucei gambiense in West and Central Africa
...
and by T. brucei rhodesiense in East Africa; both species are endemic in Uganda. Trypanosoma brucei gambiense accounts for 98% of all cases of African trypanosomiasis, and T. brucei rhodesiense accounts for 2%. African trypanosomiasis has been targeted for eradication by the World Health Organization (WHO) and, as a result of control efforts, there has been a dramatic decrease (> 95%) in the number of reported cases worldwide.
Professional version as well as patient education
more
An Independent Report
of the West Africa Commission on Drugs
The New England Journal of Medicine has a perspective on Ebola Virus Disease in West Africa — Clinical Manifestations and Management, written by
...
authors who have cared for more than 700 patients with EVD between August 23 and October 4, 2014, in the largest Ebola treatment unit in Monrovia, Liberia (Free Access) NEJm, November 5, 2014DOI: 10.1056/NEJMp1413084
more
IDS Practice Paper in Brief 23
Please find the latest interactive infographic on the websitehttp://www.humanitarianresponse.info/fr/operations/west-and-central-
...
africa/infographies-interactives. Click any chart or on the map to filter the data set
more
MMC Briefing Paper, February 2021
Briefing on the Situation of Ebola Virus Disease in Coastal West Africa and the Response of the Caritas Confederation and other Catholic Church-inspired Organizations
Vitillo, B.
(2014)
Report of Meeting: 4 November 2014, Roma
The Regional Child Protection Operational Note has been developed by IOM and UNICEF’s Regional and Country Offices in North, West
...
and Central Africa as a collaborative inter-agency and cross-regional endeavour within the framework of the sixth phase of the IOM Regional Development and Protection Programme (RDPP) for North Africa, a regional initiative funded by the European Union through the Directorate‑General for Migration and Home Affairs and the Italian Ministry of Interior.
more
Clinical Key
Elsevier
(2014)
Elsevier Provides Free Online Access to Medical Information for West African Countries Stricken with Ebola Outbreak
To support healthcare professionals in West
...
Africa battling the Ebola outbreak, Elsevier [http://www.elsevier.com/] will provide free access to its primary online clinical infomation and reference tool, ClinicalKey. The African countries that are part of this free r-
ClinicalKey access program include the four in West Africa currently affected –Liberia, Nigeria, Sierra Leone and Guinea –plus other African countries where the outbreak has the potential to spread, including Cameroon, Central African Republic, Ghana, Angola, Togo, United Republic of Tanzania, Ethiopia, Mozambique, Burundi, Equatorial Guinea, Madagascar and Malawi. All IPs originating from these countries will be granted free access for the next two months
more
More countries eliminate human African trypanosomiasis as a public health problem: Benin and Uganda (gambiense form) and Rwanda (rhodesiense form)
Human African trypanosomiasis (HAT), or sleeping s
...
ickness, transmitted by tsetse flies in sub-Saharan Africa, is a life-threatening disease that afflicts poor rural populations. It is caused by trypanosome parasites of 2 subspecies: Trypanosoma brucei gambiense in West and Central Africa, and T. b. rhodesiense in East Africa.
HAT transmission can be reduced and interrupted by deploying and maintaining capacities for testing people at risk in order to detect and treat cases, and by controlling tsetse populations that are in contact with humans.
more
BMJ Glob Health 2019;4:e001272. doi:10.1136/bmjgh-2018-001272
Trust is an essential component of successful cooperative endeavours. The global health response to the 2014–2016 West Africa Ebola o
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utbreak confronted historically tenuous regional relationships of trust. Challenging sociopolitical contexts and initially inappropriate communication strategies impeded trustworthy relationships between communities and responders during the epidemic. Social scientists affiliated with the Ebola 100-Institut Pasteur project interviewed approximately 160 local, national and international responders holding a wide variety of roles during the epidemic
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Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West
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and Central Africa. Despite the severity of the infection, therapeutic options are limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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Human African trypanosomiasis (HAT), or sleeping sickness, is caused by trypanosome parasites that are transmitted by tsetse flies. HAT is found only in sub-Saharan Africa. Two subspecies of Trypanosoma brucei cause disease: T. b. gambiense in
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West and Central Africa, and T. b. rhodesiense in East Africa.
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Updated version June 2015
