RBC/IHDPC/ EID Division | November2011 - The aim of the standard operating procedures is to guide health care providers and public health
experts from various levels of the health system in the implementation of enhanced surveillance of meningococcal meningitis.
WHO/iVB.11.09
WHO manual, 2nd edition
Нозокомиальный менингит (НМ) является одним из грозных осложнений, возникающих у пациентов после черепномозговых травм и ней-рохирургических вмешательств в ... связи с раз-вившейся бактериемией. Распространённость НМ варьирует достаточно широко, составляя 0,8–17% от общего количества прооперирован-ных пациентов, а его развитие сопровождает-ся высоким риском неблагоприятного исхода. Летальность от НМ у нейрохирургических боль-ных колеблется от 20% до 50%. Диагностика строится на клинических данных, а также резуль-татах исследования ликвора, биохимического и микробиологического анализов. В данной статье представлены последние данные по этиологии, патогенезу, диагностике и лечению пациентов с нозокомиальным менингитом.
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Report for WHO Meningitis guideline revision
Dr Thomas Waite, April 2014
Field Epidemiology Services, Public Health England; UK
Report for the WHO Meningitis Guideline Revision (May 2014)
Guide de référence rapide à l’intention des autorités sanitaires et des soignants
Révisé en 2015
Hight threat in 2018-2019
Accessed: 11.03.2019
В статье представлен анализ имеющихся в настоящее время возможностей диагностики бактериальных менингитов, лечения и ведения больных с этим заболеванием... с точки зрения доказательной медицины. В основу легли опубликованные результаты исследований в данной области. Приведены аргументы за и против использования соответствующих методов диагностики бактериальных менингитов, различные мнения относительно сроков начала антимикробной терапии и целесообразности использования дополнительной терапии глюкокортикоидами на основании результатов клинических исследований и их качества. Представлены современные антимикробные средства и режимы терапии бактериальных менингитов у пациентов разных возрастных категорий в зависимости от предполагаемой и подтвержденной этиологии заболевания.
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Cryptococcal disease is one of the most common opportunistic infections among people living with advanced HIV disease and is a major contributor to severe illness, morbidity, and mortality, particularly in sub-Saharan Africa.
These guidelines update the recommendations that were first released i...n 2018 on diagnosing, preventing, and managing cryptococcal disease. In response to important new evidence that became available in 2021, these new guidelines strongly recommend a single high dose of liposomal amphotericin B as part of the preferred induction regimen for the treatment of cryptococcal meningitis in people living with HIV. This simplified regimen - a single high dose of liposomal amphotericin B paired with other standard medicines (flucytosine and fluconazole) - is as effective as the previous WHO standard of care, with the benefits of lower toxicity and fewer monitoring demands.
The objective of these guidelines is to provide updated, evidence-informed recommendations for treating adults, adolescents and children living with HIV who have cryptococcal disease. These guidelines are aimed at HIV programme managers, policymakers, national treatment advisory boards, implementing partners and health-care professionals providing care for people living with HIV in resource-limited settings with a high burden of cryptococcal disease.
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Response to the tropical cyclone in southern Africa
Ebola virus disease outbreak in the Democratic Republic of the Congo
Meningitis outbreak in Togo
Lassa fever outbreak in Liberia.
For SARS-CoV-2 testing only
On the 31st December 2019, the World Health Organization (WHO) China country office reported a cluster of pneumonia cases in Wuhan City, Hubei Province of China now known to be caused by a novel virus. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been confirmed as the causative v...irus of Coronavirus disease 2019 (COVID-19). Cases have now been identified in over 100 countries including South Africa.
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Outline
• Welcome and objectives
• Microbiology, epidemiology and clinical presentation
• Surveillance for imported cases including case definitions
• Laboratory diagnosis • Infection prevention and hospital readiness
• Patient flow and actions required at each step
• Co-ord...inating a public health response
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1. What is COVID-19?
2. Who is at most risk for COVID-19?
3. What is the risk of COVID-19 infection in humans in South Africa?
4. How is COVID-19 transmitted?
5. What are the signs and symptoms of COVID-19 infection in humans?
6. How is COVID-19 diagnosed?
7. How is COVID-19 infection ...treated?
8. How can COVID-19 infection in humans be prevented?
9. What measures have been put in place in South Africa to minimise the risk of transmission should cases be imported?
10. Should I travel now?
11. Who can I contact for more information?
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The information contained in this document, be it guidelines, recommendations, diagnostic algorithms or treatment regimens, are offered in this document in the public interest. To the best of the knowledge of the guideline writing team, the information contained in these guidelines is correct. Imple...mentation of any aspect of these guidelines remains the responsibility of the implementing agency in so far as public health liability resides, or the responsibility of the individual clinician in the case of diagnosis or treatment.
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Defeating meningitis by 2030: a roadmap
The Updated guidelines on Management of tuberculosis in children and adolescents include new recommendations that cover diagnostic approaches for TB, shorter treatment for children with non-severe drug-susceptible TB, a new option for the treatment of TB meningitis, the use of bedaquiline and delama...nid in young children with multidrug- and rifampicin-resistant TB and decentralized and family-centred, integrated models of care for TB case detection and prevention in children and adolescents.
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Cryptococcal disease, particularly cryptococcal meningitis is a significant cause of morbidity and mortality among people living with HIV with advanced HIV disease. It is estimated that it is responsible for nearly 19% of AIDS-related mortality, second only to tuberculosis. Rapid screening, diagnosi...s and linking to appropriate treatment are critical actions national programs must take to reduce the burden of disease.
WHO in 2022 introduced updated guidelines for diagnosing, preventing, and managing cryptococcal disease among adults, adolescents and children living with HIV. This policy brief provides a summary of the key recommendations, clinical considerations, and also stresses the importance of ensuring access to life-saving antifungals. There is an urgent need for countries to scale-up management for not just cryptococcal meningitis, but address cryptococcal disease in the context of a package of care for advanced HIV disease as recommended by WHO.
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