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Bull World Health Organ 2016;94:554–556 | doi: http://dx.doi.org/10.2471/BLT.15.162610
The Lancet Global Health Volume 7, ISSUE 7, e912-e922, July 01, 2019
After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery for HAT with special emphasis on the discovery, pre-clinical development, and operational challenge
...
s of the clinical trials of fexinidazole. The screening of the Drugs for Neglected Diseases initiative (DNDi) HAT-library by the Swiss TPH had singled out fexinidazole, originally developed by Hoechst (now Sanofi), as the most promising of a series of over 800 nitroimidazoles and related molecules. In cell culture, fexinidazole has an IC50 of around 1 µM against Trypanosoma brucei and is more than 100-fold less toxic to mammalian cells. In the mouse model, fexinidazole cures both the first, haemolymphatic, and the second, meningoencephalitic stage of the infection, the latter at 100 mg/kg twice daily for 5 days. In patients, the clinical trials managed by DNDi and supported by Swiss TPH mainly conducted in the Democratic Republic of the Congo demonstrated that oral fexinidazole is safe and effective for use against first- and early second-stage sleeping sickness. Based on the positive opinion issued by the European Medicines Agency in 2018, the WHO has released new interim guidelines for the treatment of HAT including fexinidazole as the new therapy for first-stage and non-severe second-stage sleeping sickness caused by Trypanosoma brucei gambiense (gHAT). This greatly facilitates the diagnosis and treatment algorithm for gHAT, increasing the attainable coverage and paving the way towards the envisaged goal of zero transmission by 2030.
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The Cardiovascular Journal of Africa (CVJA) is an international peer-reviewed journal that keeps cardiologists up to date with advances in the diagnosis and treatment of cardiovascular disease. Topics covered include coronary disease, electrophysiology, valve disease, imaging techniques, congenital
...
heart disease (fetal, paediatric and adult), heart failure, surgery, and basic science.
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Lancet 2013; 381: 1405–16
Series: Childhood Pneumonia and Diarrhoea no.1
Lancet. 2018 Dec 19. pii: S0140-6736(18)31647-7. doi: 10.1016/S0140-6736(18)31647-7. [Epub ahead of print]
Rund drei Viertel der in Deutschland lebenden Flüchtlinge aus Syrien, dem Irak und Afghanistan sind nach Gewalterlebnissen traumatisiert.
Neue Empfehlungen für die Umgebungsuntersuchungen bei Tuberkulose
Diel, R., G. Loytved, A.Nienhaus, et al.
Deutsches Zentralkomitee zur Bekämpfung der Tuberkulose
(2011)
C2
DOI http://dx.doi.org/ 10.1055/s-0030-1256439 Online-Publikation: 10. 5. 2011 Pneumologie 2011; 65: 359–378
Accessed January 22, 2019.
This updated version include important research that has added to our knowledge about effective treatments for
child and adolescent depression. Its goal is to help parents and families make informed decisions about getting the best care for a child with depression. For
...
easy use, it is presented in Frequently Asked Questions (FAQ) format.
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La crisis del sistema de salud colombiano: una aproximación desde la legitimidad y la regulación
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Suárez-Rozo LF, Puerto-García S, Rodríguez-Moreno LM, Ramírez-Moreno
Rev. Gerenc. Polit. Salud, Bogotá, Colombia
(2017)
C1
El objetivo fue determinar cuáles son las percepciones de distintos actores del sistema de salud
colombiano sobre los problemas del sistema que están detrás de la crisis. Se realizó un estudio
cualitativo a partir de entrevistas semiestructuradas y en profundidad con cuarenta agentes del
sect
...
or salud, en Bogotá, Cali, Ibagué, Espinal y Calima-Darién. Los resultados mostraron que la
corrupción, el incumplimiento de normas y los conflictos entre los intereses de diversos actores
del sistema debilitan la legitimidad de este último, atomizan la cooperación y cohesión de los
actores y fortalecen el interés particular.
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DOI: 10.1126/science.aax2196; Science 08 Mar 2019: Vol. 363, Issue 6431, pp. 1017
The health system in Venezuela: a patient without medication?
Cad. Saúde Pública 34 (3) 05 Mar 2018 • https://doi.org/10.1590/0102-311X00058517
In: Mental health nursing: dimensions of praxis. Oxford University Press, Melbourne, Australia, pp. 427-442. ISBN 9780195566963
This chapter introduces you to the importance of culturally based health and well-being and to health care delivered by mental health nurses. There is a need for mental h
...
ealth professionals to incorporate knowledge about these beliefs and to develop the skills to work with clients from cultures other than their own if they are to care for them effectivel
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Afr J Psychiatry 2011;14:200-207
https://www.researchgate.net/publication/47460246_Mental_illness-stigma_and_discrimination_in_Zambia
Int Nurs Rev. 2018 Mar;65(1):78-92. doi: 10.1111/inr.12391. Epub 2017 May 25.
International Journal of Psychiatry in Clinical Practice, 2012; 16: 77–84