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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Policy Brief for the Legal Framework on Infection Prevention and Control

African Union; Africa CDC Centres for Disease Control and Prevention (2022) C1

The Infection Prevention and Control (IPC) Legal Framework comes before the Specialized Technical Committee on Health and Drug Control for adoption and endorsement. The IPC Legal Framework is designed to guide Member States in the review and strengthening of laws and policies that support IPC at bot... more

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Consultation with Children in East Africa for the World Humanitarian Summit - Messages from Children Affected by Emergencies

Save the Children (2015) CC

Children expressed the need for organisations to support in the delivery of services such as health and sanitation. The children also emphasized that schools and the child-friendly spaces (CFSs) were effective and important spaces to provide them with what they need.

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Infection Control outside the VHF Treatment Facility

MSF (2008)

This section deals with implementing and improving infection control practices in hospitals, health centres and other health services in the outbreak area. It explains the need for, and implementation of, effective triage procedures, and basic requirements for infection control and supporting activi... more

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National Strategic Plan Public Private Mix in Tuberculosis (2016-2020)

National TB Control Programme (NTP), DGHS, MoHFW (2016) C1

This 2016-2020 public-private mix strategic plan (PPM SP) is a 4-year framework designed to guide the National TB Control Programme (NTP) and its partners to implement PPM in Bangladesh. It provides goals, strategies and interventions for expanding and scaling up current PPM models and outlines appr... more

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COVID-19 Guidance Note: Virtual Inclusive Dialogue

Reliefweb; OCHA Services; The Global Fund (2020) C2

Date issued: 14 April 2020 The Global Fund is committed to ensuring that input from those closest to and living with HIV, tuberculosis and malaria are included in every funding request to the Global Fund. Their input is critical to ensuring that programs are effective and designed to help those m... more

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Smartphone‑based objective monitoring in bipolar disorder: status and considerations

Maria Faurholt-Jepsen, Michael Bauer and Lars Vedel Kessing (2018) CC

Int J Bipolar Disord (2018) 6:6 https://doi.org/10.1186/s40345‑017‑0110‑8 In 2001, the WHO stated that: "The use of mobile and wireless technologies to support the achievement of health objectives (mHealth) has the potential to transform the face of health service delivery across the globe"... more

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Guidance on infection prevention and control of COVID-19 in migrant and refugee reception and detention centres in the EU/EEA and the UK

European Centers for Disease Control and Prevention ECDC (2020) C_CDC

The main objective of this guidance is to provide scientific advice on public health principles and considerations for infection and prevention control of COVID-19 in migrant and refugee reception and detention centres in the European Union and European Economic Area (EU/EEA) and the United Kingdom ... more

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Medication review and medicines use review

International Pharmaceutical Federation (FIP) (2022) CC

A toolkit for pharmacists. Emerging data show that medication errors and adverse events cause significant harm to patients’ health and well-being. It is estimated that the burden of adverse events due to medicines is now comparable to that of widespread diseases, such as malaria or tuberculosis... more

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Ebola Myths, Realities and Structural Violence

ANNIEWILKINSON ANDMELISSA LEACH (2014)

The scale of West Africa’s Ebola epidemic has been attributed to the weak health systems of affected countries, their lack of resources, the mobility of communities and their inexperience in dealing with Ebola. This briefing for African Affairs argues that these explanations lack important contex... more

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The Role of Nursing Homes in the Spread of Antimicrobial Resistance Over the Healthcare Network

van den Dool C., PhD; A. Haenen; T. Leenstra, MD, PhD; et al. (2016) C2

The spread of antimicrobial-resistant microorganisms poses anincreasing threat to affordable modern health care. In the Netherlands, efforts to control the dispersal of known and novel antimicrobial-resistant organisms have been mostly implemented at the hospital level. However, recent studies have ... more

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Guidance on chlamydia control in Europe

European Centre for Disease Prevention and Control (2016) C1

This document updates the 2009 ECDC guidance on chlamydia control in Europe. It was developed by a technical expert group which conducted a critical review of the scientific evidence on the epidemiology of chlamydia and the effectiveness of screening programmes. The aim of this guidance is to suppo... more

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Essential WASH Actions: A Training & Reference Pack to Supplement Essential Nutrition Actions

Rosenbaum, Julia and Bery, Renuka (2017) C1

The Essential WASH Actions toolkit expands the connection between WASH and nutrition. This resource offers a comprehensive set of essential WASH actions, references training materials for health workers, nutrition managers and community workers to build capacity, and outlines accompanying behaviors ... more

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MEAL4KIDS: Quality Checklist - For Child Psychosocial Support and Child Friendly Spaces

Bohl, N Catholic Relief Services (CRS) (2018) CC

This checklist will help child psychosocial support and Child Friendly Space supervisors adhere to quality standards during program implementation. This checklist was developed by consultant Nicole Bohl, based on her previous work with Plan International and Save the Children. It has been adapted wi... more

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Republic of Kenya: National Policy on Prevention and Containment of Antimicrobial Resistance

Government of Kenya (2017) C2

Antimicrobial resistance (AMR) is a global threat that requires urgent collaborative action within and among countries. AMR makes standard treatments ineffective and facilitates the spread of antimicrobial resistant infections rendering communities vulnerable. The Ministry of Health (MOH) and Minist... more

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Nutrition Program Design Assistant: A Tool for Program Planners (NPDA)

CORE Group Nutrition Working Group, Food and Nutrition Technical Assistance III Project (FANTA), and Save the Children (2015)

Reference Guide Version 2. Revised. The Nutrition Program Design Assistant is a tool to help organizations design the nutrition component of their community-based maternal and child health, food security, or other development program. The tool focuses on prevention and also provides guidance on recu... more

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Maternal, Infant and Young Child Nutrition MIYCN Guidelines

Republic of South Sudan (2017) C1

Maternal, Infant and Young Child Nutrition Strategic Actions:
1 Endorse and disseminate key policies and regulations
2 Improve maternal nutrition
3 Protect, promote, and support optimal infant and young child feeding practices
4 Support optimal infant and young child feeding in ... more

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Disease Control Priorities 3: Palliative Care and Pain Control

World Bank (2018) C1

Palliative care has been shown to provide significant and diverse benefits for patients with serious, complex,or life-limiting health problem. Jamison DT, Gelband H, Horton S, Jha P, Laxminarayan R, Mock CN, Nugent R., editors. Disease Control Priorities, 3rd Edition, Volume 9: Improving Health an... more

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Continental Framework on Strengthening Mortality Surveillance Systems in Africa

Africa Center for Disease Control and Prevention (2023) CC

The importance of robust mortality surveillance systems cannot be overstated in an era marked by increasing global health challenges where health threats loom large and population dynamics continue to evolve. Accurate and timely mortality data is essential for identifying trends and detecting emergi... more

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Financing HIV Programming: How Much Should Low And Middle-Income Countries and their Donors Pay?

Galarraga, O.; V. J. Wirtz; Y. Santa-Ana-Tellez et al. PLOS One (2013) C1

Global HIV control funding falls short of need. To maximize health outcomes, it is critical that national governments sustain reasonable commitments, and that international donor assistance be distributed according to country needs and funding gaps. We develop a country classification framework in t... more