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Infectious disease outbreaks and epidemics are increasing in frequency, scale and impact. Health care facilities can amplify the transmission of emerging infectious diseases or multidrug-resistant organisms (MDRO) within their settings and communities. Therefore, evidence-based infection prevention
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and control (IPC) measures in health care facilities are critical for preventing and containing outbreaks, while still delivering safe, effective and quality health care. This toolkit is intended to support IPC improvements for outbreak management in all such facilities, both public and private throughout the health system. Specifically, this document systematically describes a framework of overarching principles to approach the preparedness, readiness and response outbreak management phases. The document also provides a toolkit of resource links to guide specific actions for each infectious disease and/or MDRO outbreak management phase at any health facility. This document is specifically tailored to an audience of stakeholders who establish and monitor health care facility-level IPC programs including: IPC focal points, epidemiologists, public health experts, outbreak response incident managers, facility-level IPC committee(s), safety and quality leads and managers, and other facility level IPC stakeholders.
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Africa CDC Institute of Pathogen Genomics (IPG) was launched in November 2019 and operates under the Division of Laboratory Systems and Networks.
IPG coordinate the implementation of molecular diagnostics, pathogen genomics and bioinformatics in National Public Health Institutions (NPHIs) and/or Re
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fe-
-rence Laboratories (NRLs) across Africa.
Africa CDC and APHF are coordinating a continental initiative to maximize the benefits of molecular approaches and pathogen genomics for more effective
outbreak preparedness, prevention, response, and for the control and elimination of endemic diseases in Africa. One of Africa CDC’s flagship initiative is the Africa
Pathogen Genomics Initiative (Africa PGI), a partnership that aims to strengthen laboratory systems and enhance genomic surveillance by equipping the continent’s
public health institutions with the tools, training, and data infrastructure.
About the Project
In 2023, 166 outbreaks and public health events were reported in Africa. This calls for a resilient laboratory systems for timely detection and reporting of current and future outbreaks. This project aims to scale up molecular diagnostic and genomic sequencing-based detection and characterization of outbreaks.
Africa CDC is working with Member States to develop guidance, diagnostic algorithm, training and capacity building to enable outbreak detection, and reporting to inform public health response.
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On March 16, 2023, the Tanzania Ministry of Health declared an outbreak of an unidentified illness in Bukoba district, Kagera region. A group of seven individuals presented with fever, vomiting, bleeding from various body orifices, and kidney failur
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e, sparking suspicion of a contagious disease. Laboratory results from patients and the deceased confirmed the Marburg virus disease (MVD) outbreak on March 21, 2023.
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Médecins Sans Frontières (MSF) has set up a 20-bed cholera treatment unit (CTU) at the Renk Civil Hospital in South Sudan, in response to a cholera outbreak declared by the Ministry of Health (MoH) on 28 October. We call on all organisations in Up
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per Nile state to help prevent the spread of the disease within Upper Nile State and beyond.
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On 4 September 2025, the Ministry of Health of the Democratic Republic of the Congo (DRC) declared an outbreak of Ebola Virus Disease (EVD) in Kasai Province, following confirmation of Zaire ebolavirus by the National Institute of Biomedical Researc
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h (INRB) in Bulape and Mweka Health Zones. As of 19 September, there have been 48 total cases (38 confirmed, 10 probable) with 31 deaths (21 confirmed, 10 probable) and a CFR of 64.5%. Among laboratory confirmed cases, 16 deaths were recorded (CFR: 45.7%). Four deaths occurred among health workers, underscoring the risk of nosocomial transmission. Most cases (39.7%) are among adults aged 20 years and above, in a densely populated, remote, and under-resourced area.
The outbreak is driven by multiple risk factors, including transmission in health facilities with limited infection prevention and control (IPC) measures and personal protective equipment (PPE), incomplete contact tracing, delayed detection, and unsafe burial practices. High population mobility between Bulape and Tshikapa, reliance on traditional healers, and the concurrent mpox outbreak are further straining the fragile health system and increasing the risk of geographic spread.
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Front. Commun., 17 February 2025 Sec. Health Communication, Volume 9 - 2024 | https://doi.org/10.3389/fcomm.2024.1509940. Effective risk communication during enteric illness outbreak investigations requires public health authorities to identify, cha
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racterize, tailor information to, and meaningfully engage with their target audiences, build relationships and collaborate with media outlets, and maintain and increase credibility to deliver trustworthy risk communication message
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Please read the text online on the CDC website http://www.cdc.gov/vhf/ebola/hcp/limiting-heat-burden.html
Recommended measures for medical and other staff who were involved in patient care or outbreak response during the Ebola outbreak in 2014
Robert-Koch-Institut
(2014)
This document describes recommended measures for dealing with medical and other staff employed either in patient care or in outbreak control during the 2014 Ebola outbreak.
This Roadmap is structured around a results-based framework of outcomes, outputs and deliveraebles, to ensure that WHO maintains appropriate levels of organizational readiness, supports country-level capacity building and preparedness, deploys efficiently and effectively to respond to outbreaks and
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emergencies at national and subnational levels, and engages effectively with partners and stakeholders throughout
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This report documents the secondary humanitarian problems and impacts of large-scale Ebola outbreak on the different humanitarian sectors, to provide a non-exhaustive plan to help future responders. A large scale Ebola
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outbreak, in this document, refers to an epidemic with an unprecedented scale, geographical spread and duration.
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Lancet Glob Health 2016; 4: e856–63. Open Access
The article "Effectiveness of one dose of oral cholera vaccine in response to an outbreak: a case-cohort study" investigates whether a single dose of the Shanchol oral cholera vaccine can provide e
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ffective protection during an outbreak. Conducted in Juba, South Sudan, in 2015, the study involved a case-cohort approach, analyzing vaccination status and disease outcomes.
Findings showed that a single dose was 80.2% effective in preventing medically attended cholera cases, increasing to 87.3% after adjustments for confounding factors. These results suggest that a single-dose strategy can be an effective emergency response, particularly in settings with limited vaccine supply and high mobility of affected populations. The study supports using a single-dose approach during outbreaks when a two-dose regimen is logistically challenging.
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Detection, Confirmation and Management of a Dysentery Outbreak caused by Shigella Dysenteriae type 1
Standard Operating Procedures | RBC/IHDPC/EID Division | 9/30/2011
Social science and behavioural data compilation, DRC Ebola outbreak, June - August 2019
Bardosh, K.; T. Jones and J. Bedford
Social Science in Humanitarian Action: A Communication for Development Platform
(2019)
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This rapid compilation of data analyses provides a ‘stock-take’ of social science and behavioural data related to the on-going outbreak of Ebola in North Kivu, South Kivu and Ituri provinces. Based on data gathered and analysed by organisations
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working in the Ebola response and in the region more broadly, it explores convergences and divergences between datasets and, when possible, differences by geographic area, demographic group, time period and other relevant variables. Data sources are listed at the end of the document.
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Report for WHO Meningitis guideline revision
Dr Thomas Waite, April 2014
Field Epidemiology Services, Public Health England; UK
Briefing note on addressing mental health and psychosocial aspects of COVID-19 Outbreak- Version 1.1
recommended
This briefing note summarises key mental health and psychosocial support (MHPSS) considerations in relation to the 2019 novel coronavirus (COVID-19) outbreak.
Coronavirus (Covid-19) - A collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary.
The New England Journal of Medicine; Massachusetts Medical Society
The New England Journal of Medicine; Massachusetts Medical Society
(2020)
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Accessed: 25.03.2020
Communique by the Emergency Meeting of African Ministers of Health on the Coronavirus Disease Outbreak (Arabic)
African Union; Africa CDC Centres for Disease Control and Prevention (Safeguarding Africa's Health)
African Union; Africa CDC Centres for Disease Control and Prevention (Safeguarding Africa's Health)
(2020)
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Accessed: 01.04.2020
