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Buruli ulcer (BU) is a skin-related neglected tropical disease (skin NTD) caused by infection with
Mycobacterium ulcerans. BU is the third most common mycobacterial disease after tuberculosis and leprosy
in people who are not immunocompromised. The infection manifests in non-ulcerative forms as no
...
dules,
plaques and/or oedemas, which ulcerate within 4–6 weeks and display characteristic undermined edges and yellowish-white necrotic slough . Most lesions occur on the lower limbs.
more
The 2022 report reviews the global malaria diagnostics market and technological landscape to support Unitaid’s 2023–2027 strategy for quality malaria case management. The report highlights the stalled progress of malaria control efforts, the gaps in access to diagnostics and the public health im
...
plications of P. falciparum HRP2/3 gene deletions, which compromise the accuracy of the widely used HRP2-detecting rapid diagnostic tests (RDTs). The report analyses the malaria RDT market, noting supplier diversification, price trends and production shifts resulting from the pandemic. It also addresses the emerging point-of-care G6PD testing market, which is required to ensure the safe radical cure of P. vivax infections. It surveys technological innovation, including digital microscopy, hemozoin tests, nucleic acid detection and biosensors, while emphasising that RDTs and microscopy will remain the mainstay of case management in the near term. The report identifies market shortcomings, access barriers and opportunities to improve malaria case management and diagnostic coverage.
more
The Best Buys for Disease Elimination is a practical, evidence-based guide to the most effective actions for countries to implement in order to eliminate communicable diseases. The guide highlights the efficient use of resources and prioritizing populations in vulnerable situations.
“The Region
...
of the Americas is advancing steadily towards the elimination of communicable diseases,” said Dr. Jarbas Barbosa, PAHO Director. “To achieve this, it is necessary to increase and sustain high vaccination coverage, engage communities to expand access to diagnosis and treatment, strengthen surveillance, and bring integrated services to marginalized communities, incarcerated populations, and those living in informal settlements,” he added.
For each disease and condition included in the Elimination Initiative, the Best Buys are presented as one-page documents with clear, accessible information. Each Best Buy summarizes expected impact goals, disease elimination targets, key operational indicators, and priority interventions that have proven to be cost-effective in different contexts.
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In an era of constrained resources and tightening budgets, strategic prioritization in tuberculosis (TB) programming is more critical than ever. Countries must make informed decisions to allocate limited resources effectively - maximizing impact, preventing avoidable deaths, and sustaining progress
...
towards ending TB.
more
Rwanda’s mountainous topography makes ground transportation of medical supplies unreliable — some roads stretching into rural areas remain uncared for and unpaved. Between 25 and 40 per cent of all temperature-sensitive medical supplies sent from urban centres to rural health clinics are wasted
...
because of an unreliable cold-chain infrastructure. Rural clinics are also often subject to stockouts, and patients in need of specialized blood products, drugs and other supplies are unable to acquire them. Zipline, a US-based health logistics company, aims to address the issue of access to medical supplies, largely leapfrogging traditional modes of transportation and various obstacles. Zipline uses drones to deliver blood and other routine and emergency medical supplies from distribution centres to district hospitals and rural health centres.
Although the company has been celebrated in the media for its operations, there is little scholarly work on its operations and performance. This has led to some confusion over its scale. We aimed to gain insight into the details of Zipline’s business model, including the infrastructure, regulations and government support that make Zipline possible, and to understand its impact on health outcomes in Rwanda. Our work was entirely based on published materials since our research was conducted during the COVID-19 pandemic.
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Data presentation is the basis for describing data and generating hypotheses for further testing. It consists of a number of methods for summarising data in order to support the identification of patterns. Data can be summarised in a number of forms, including tables or graphical representations s
...
uch as graphs or maps. Effective data presentation requires an understanding of the principles introduced in this guide.
more
The UNICEF Gender Equality Action Plan, 2026–2029 provides the road map
for the organization’s key commitments to advancing gender equality and the
empowerment of all girls and women, anchored in the UNICEF Strategic Plan,
2026–2029.
The NIAID Pandemic Preparedness Plan describes the strategy of the National Institute of Allergy and Infectious Diseases (NIAID) to strengthen research and development for future pandemic threats. The plan focuses on identifying and studying viruses with the potential to cause epidemics or pandemics
...
and developing medical countermeasures such as vaccines, therapeutics and diagnostics. A key concept is the research on “prototype pathogens,” which represent virus families that may cause future outbreaks, allowing scientists to prepare tools and knowledge in advance. The document also outlines the importance of surveillance, epidemiological research, technological innovation, clinical trials and international collaboration to enable a faster and more effective response to emerging infectious diseases. Overall, the plan aims to improve scientific preparedness so that new health threats can be detected earlier and controlled more rapidly.
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International Journal for Parasitology: Drugs and Drug Resistance Volume 28, August 2025, 100602
This review provides innovative insights to circumvent antimalarial drug resistance and diversify malaria therapeutics.
The Global hepatitis report 2026 provides the most comprehensive and up-to-date assessment of the global burden of hepatitis B (HBV) and hepatitis C (HCV), which together account for more than 95% of deaths related to viral hepatitis. Despite being preventable and treatable, viral hepatitis remains
...
one of the leading infectious disease killers worldwide.
The report also highlights the progress in response efforts at global, regional and country levels, in the context of global commitments, strategies and targets.
more
Epidemic Preparedness and Response in Africa | Guidelines for the Decentralization of Laboratory Capacity
recommended
New
The decentralization of laboratory capacities is a critical strategy for improving epidemic preparedness and response in Africa. Centralized systems often delay case confirmation, hinder timely interventions, and exacerbate the impact of outbreaks, especially in rural and hard-to-reach areas.
Thi
...
s Guidelines outlines a structured approach to decentralization, focusing on:
Strategic Goals: Strengthening laboratory capacity at subnational levels to ensure timely detection and control of epidemic-prone diseases.
Guiding Principles: Equity, country ownership, multisectoral collaboration and evidence-based decision-making.
Implementation Framework: Practical steps for planning, executing, and sustaining decentralized diagnostic networks, with intra- and post-implementation reviews for continuous improvement.
Integration: Alignment with existing surveillance, case management and infection prevention and control (IPC) systems, with a focus on the One Health approach.
While the Guidelines is informed by the Mpox outbreak response, it is adaptable to other priority diseases and aligned with the International Health Regulations (IHR 2005), the Africa CDC Strategic Plan (2022-2027), and the WHO Health Security Framework.
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Préparatiom et la riposte aux Épidémies er Afrique guide de Décentralisation des capacités de Laboratoire
recommended
New
L’augmentation en fréquence et en ampleur des urgences de santé publique en Afrique met en évidence
l’importance cruciale d’un dépistage précoce, d’une intervention rapide et d’un accès équitable aux
capacités de laboratoire. Les systèmes centralisés se sont souvent révélés
...
insuffisants, notamment
dans les zones reculées ou mal desservies, entraînant des retards dans la confirmation des cas et
réduisant l’efficacité des mesures de contrôle des épidémies.
La décentralisation des capacités de laboratoire constitue une stratégie transformative pour combler
ces lacunes. En rapprochant les examens diagnostiques des points de prestation de soins, les États
Membres de l’Union Africaine peuvent détecter les épidémies plus tôt, réagir plus efficacement et
renforcer la confiance du public dans les systèmes de santé.
Ce document propose un cadre global pour aider les États Membres à concevoir, mettre en œuvre
et pérenniser des réseaux de diagnostic décentralisés. Il met l’accent sur l’équité, l’appropriation
nationale, la collaboration multisectorielle et l’intégration avec les autres fonctions du système de santé.
De plus, il souligne l’importance du maintien des normes de qualité dans les contextes décentralisés,
en recommandant la mise en place de dispositifs de contrôle qualité adaptés, de mécanismes de
supervision ciblés et l’harmonisation avec les cadres nationaux d’assurance qualité.
Africa CDC, l’OMS et leurs partenaires restent déterminés à soutenir les États Membres à travers une
assistance technique, des plateformes de coordination et la mobilisation de ressources. Ensemble,
nous pouvons bâtir un écosystème de diagnostic résilient, réactif et inclusif, protégeant la santé de
toutes les communautés africaines.
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The second edition of the WHPCA Global Atlas of Palliative Care was launched during World Hospice & Palliative Care Day 10 October. The Atlas is an update of the original WHPCA/WHO Global Atlas of Palliative care at the end of life published in 2014. It is full of useful facts and figures to support
...
palliative care advocacy and development. In this edition we have switched from using the WHO methodology for need for palliative care to the evolving Lancet Commission on Palliative Care and Pain Relief methodology. As a result the number of people needing palliative care has gone from 40 million per year to almost 57 million and more accurately reflects the need for palliative care globally models of palliative care worldwide? What resources are devoted to palliative care? What is the way forward?
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In: Bonk M., Ulrichs T (eds). Global Health: Das Konzept der Globalen Gesundheit. Berlin: De Gruyter, 2021, pp. 523–556
Wohlstand, Gesundheit und Gesundheitsausgaben sind eng miteinander verknüpft. Im weltweiten Durchschnitt haben alle drei seit vielen Jahren stetig zugenommen. Im Vergleich hab
...
en Menschen in Ländern mit höheren Einkommen eine höhere Lebenserwartung. Die höchste Krankheitslast pro Mensch tritt in Ländern mit niedrigem Einkommen auf. Den größten Anteil an der gesamten globalen Krankheitslast haben Länder mit mittlerem Einkommen, in denen rund drei Viertel der Weltbevölkerung lebt. Im Mittel sind die Gesundheitsausgaben in Ländern mit höheren Einkommen insgesamt sowie pro Kopf höher als die Gesundheitsausgaben in Ländern mit niedrigeren Einkommen.
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The objectives of these WHO guidelines are to provide updated evidence- based recommendations for the treatment of persons with hepatitis C infection using, where possible, all DAA-only combinations. The guidelines also provide recommendations on the preferred regimens based on a patient’s HCV gen
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otype and clinical history, and assess the appropriateness of continued use of certain medicines. This document also includes existing recommendations on screening for HCV infection and care of persons infected with HCV that were first issued in 2014
more
Development assistance for health (DAH)
plays a vital role in supporting health programmes in lowand middle-income countries. While DAH has historically
focused on infectious diseases and maternal and child
health, there is a lack of comprehensive analysis of DAH
trends, strategic shifts and the
...
ir impact on health systems
and outcomes. This study aims to provide a comprehensive
review of DAH from 1990 to 2022, examining its evolution
and funding allocation shifts.
more
In many countries neonatal tetanus is responsible for half of all neonatal deaths due to vaccine-preventable diseases and for almost 14% of al¡ infant deaths. It is estimated that in the 1970s more than 10,000 newborns died annually from neonatal tetanus in the Americas. Neonatal tetanus is prevent
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ed by immunization and/or assuring clean delivery and post-delivery practices.
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