The recommendations in these guidelines promote the use of simple, non-invasive diagnostic tests to assess the stage of liver disease and eligibility for treatment; prioritize treatment for those with most advanced liver disease and at greatest risk of mortality; and recommend the preferred use of n...ucleos(t)ide analogues with a high barrier to drug resistance (tenofovir and entecavir, and entecavir in children aged 2–11 years) for first- and second-line treatment. Recommendations for the treatment of HBV/HIV-coinfected persons are based on the WHO 2013 Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection, which will be updated in 2015.
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La Convención de los Derechos del Niño (Convención) de las Naciones
Unidas (ONU) y documentos relacionados tienen el potencial de mejorar
enormemente varias dimensiones de la vida de los niños (definidos como
desde el nacimiento hasta la los 18 años, dependiendo de la cultura), ofreciendo
p...rotección ante el abuso, fortaleciendo la relación de los niños con sus familias
y garantizando la realización del potencial individual. Estos documentos van
más allá de implicaciones para los gobiernos y deben considerarse en relación
con todas las actividades profesionales relacionadas con la vida de los niños,
incluyendo la práctica clínica, la investigación, la participación y educación.
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Dérivant du grec τραῦμα signifiant « blessure », le mot « traumatisme »
a été utilisé durant des siècles comme un terme médical désignant « une blessure
des tissus vivants causée par un agent externe.» Ainsi, ce n’est qu’en 1889, lorsque
Oppenheim fit la première descrip...tion clinique des « névroses traumatiques »
chez des victimes d’accidents de chemin de fer, que le terme pris également une
acceptation psychologique.
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Mem Inst Oswaldo Cruz , Rio de Janeiro, Vol. 110 (3): 377-386, May 2015
Euro Surveill. 2015 Mar 26;20(12). pii: 21073.
Mood disorders
Chapter E.1
2015 edition
This document presents an integrated strategy for mental health system development that will lead to enhanced service delivery, improved outcomes, and improved human rights for people with mental disorders.
By using the practical guidance provided in this document, countries can ensure that thei...r mental health systems are not haphazard, but rather, the products of careful consideration and planning.
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(2015)
Scoping question: Are antidepressants (specifically, tricyclic antidepressants and selective serotonin reuptake inhibitors) effective and safe in adolescents with moderate-severe depressive disorder for whom psychosocial interventions have proven ineffective?
The SAARC Member States have more than an estimated 2.0 million TB cases accounting for close to one-third of the total cases of TB in the world. India alone had almost one-fifth of the global disease burden due to TB. India, Pakistan and Bangladesh followed by Afghanistan are the major contributors... of disease burden of TB in the SAARC Region. They are countries that have a dubious distinction of being on the list of 22 TB High Disease Countries in the world.
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Environmental Research Letters
Microplastic debris floating at the ocean surface can harm marine life. Understanding the severity of this harm requires knowledge of plastic abundance and distributions. Dozens of expeditions measuring microplastics have been carried out since the 1970s, but they ha...ve primarily focused on the North Atlantic and North Pacific accumulation zones, with much sparser coverage elsewhere. Here, we use the largest dataset of microplastic measurements assembled to date to assess the confidence we can have in global estimates of microplastic abundance and mass. We use a rigorous statistical framework to standardize a global dataset of plastic marine debris measured using surface-trawling plankton nets and coupled this with three different ocean circulation models to spatially interpolate the observations. Our estimates show that the accumulated number of microplastic particles in 2014 ranges from 15 to 51 trillion particles, weighing between 93 and 236 thousand metric tons, which is only approximately 1% of global plastic waste estimated to enter the ocean in the year 2010. These estimates are larger than previous global estimates, but vary widely because the scarcity of data in most of the world ocean, differences in model formulations, and fundamental knowledge gaps in the sources, transformations and fates of microplastics in the ocean.
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