The Updated guidelines on Management of tuberculosis in children and adolescents include new recommendations that cover diagnostic approaches for TB, shorter treatment for children with non-severe drug-susceptible TB, a new option for the treatment of TB meningitis, the use of bedaquiline and delama...nid in young children with multidrug- and rifampicin-resistant TB and decentralized and family-centred, integrated models of care for TB case detection and prevention in children and adolescents.
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For the molecular diagnosis of Chagas disease by real-time PCR (polymerase chain reaction), optimization of diagnostic accuracy is desirable. The detection limit of real-time PCR assays for the diagnosis of Trypanosoma cruzi in human serum is affected by various influences including the choice of th...e nucleic acid extraction assay. In this study, three nucleic acid extraction assays were compared regarding their influence on the sensitivity of a T. cruzi-specific real-time PCR with 62 reference sera containing T. cruzi target DNA (deoxyribonucleotide acid). More than 95% of the positive sera were correctly identified after all three nucleic acid extraction strategies with a detection rate ranging from 96.8% (60/62) for the worst assay to 100% (62/62) for the best one. A matched pairs analysis for the comparison of the cycle threshold (Ct) values obtained with the 59 reference samples with positive real-time PCR results after all three nucleic acid extraction schemes indicated differences in a range of about 3 Ct steps. Summarized, all three compared nucleic acid extraction schemes were basically suitable for T. cruzi-specific PCR from serum with some minor differences. However, in the case of low quantities of circulating parasite DNA in the serum of a patient with Chagas disease, even minor effects can make a difference in the individual diagnosis.
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The guide is especially appropriate for settings where the provision of medical, diagnostic and support services is sparse or lacking. It covers adult and child mental health problems, as well as childhood developmental disorders. It includes information and guidance on dealing with mental health cr...ises and emergencies and identifying mental health and developmental problems, together with simple intervention strategies, including suggestions for parents and family members to use themselves. It outlines strategies for Community Health Workers to employ in promoting mental health and in raising their community’s awareness of mental health problems
Accessed July 4, 2019
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The latest update (28 January 2021) includes the following addition and revision:
biosafety aspects for working with antigen-detecting rapid diagnostic test;
handling new variants of SARS-CoV-2 in the laboratory;
updated assay decontamination before disposal;
personal protectiv...e equipment (PPE) for specimen collection;
addressing chemical hazards and their safe disposal; and
the fourth edition of the WHO Laboratory Biosafety Manual (LBM4) is now available and the terminology in this guidance was aligned with the LBM4.
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6 July 2021. Three new nucleic acid amplification test (NAAT) classes are endorsed by WHO and included.
The latest operational handbook includes the new classes recommended by WHO. It aims at facilitating the implementation of the WHO recommendations by the Member States, technical partners, and ot...hers involved in managing patients with TB and DR-TB. The operational handbook provides practical information on existing and new tests recommended by WHO, step-by-step advice on implementing and scale-up testing to achieve local and national impact and lastly, model diagnostic algorithms, which are updated to incorporate the latest recommendations. An overview of budgetary considerations and information sheets on each of the newly recommended tests is provided.
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“Continuum of HIV services refers to a comprehensive package of HIV prevention, diagnostic, treatment, care and support services provided for people at risk of HIV infection or living with HIV and their families”
August, 2018
La page intitulée « Paludisme » sur le site des Guides médicaux de Médecins Sans Frontières (MSF) fournit des directives cliniques détaillées pour le diagnostic, le traitement et la prévention du paludisme, en particulier dans les contextes humanitaires et les zones à ressources limitées.... Elle décrit les différentes espèces de Plasmodium responsables de la maladie, les symptômes cliniques associés aux formes simples et sévères, les méthodes de diagnostic telles que les tests rapides et la microscopie, ainsi que les protocoles thérapeutiques adaptés à chaque situation, y compris pour les populations vulnérables comme les enfants et les femmes enceintes. La page aborde également les stratégies de prévention, notamment l'utilisation de moustiquaires imprégnées d'insecticide et la chimioprévention saisonnière dans les zones à transmission élevée. Ces recommandations sont basées sur les lignes directrices de l'Organisation mondiale de la santé (OMS) et l'expérience de MSF sur le terrain.
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ndependent of the current conflict, the health sector in Ukraine faces several critical shortcomings. In particular, the country has an oversupply of hospitals and an undersupply of primary care and diagnostic facilities. Addressing these limitations will require substantial amounts of capital inves...tment, but constraints on public finances in the post-war context will reduce the Government’s ability to fund the needed reconfiguration. Multiple international financial institutions have stated their intention to support reconstruction in the aftermath of the war. The use of public–private partnerships (PPPs) may support the achievement of these outcomes and their use in Ukraine is likely to remain an important issue for Government policy-makers and their partners to consider in a variety of post-war scenarios.
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Le présent document vise à fournir des orientations provisoires sur la mesure du périmètre crânien, les normes de croissance, l’évaluation clinique et les examens requis pour établir un diagnostic de microcéphalie et déterminer si elle s’accompagne d’anomalies neurologiques.
Les notes d’orientation décrivent les mesures essentielles que les décideurs nationaux et infranationaux peuvent mettre en place concernant les aspects suivants de la lutte contre la COVID-19 : les tests de diagnostic, la prise en charge clinique, la réalisation des cibles en matière de vaccin...ation, le maintien des mesures de lutte anti-infectieuse liées à la maladie dans les établissements de soins de santé, les efforts
visant à instaurer la confiance par la communication sur les risques et la participation communautaire ainsi que la gestion de l’infodémie liée à la COVID-19.
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L'anthrax est une maladie bactérienne, causée par Bacillus anthracis, qui peut se transmettre des animaux
herbivores à l'homme par contact étroit, en mangeant de la viande d'animaux infectés, ou par contamination
environnementale. L'anthrax peut être une maladie grave nécessitant un diagnos...tic et un traitement précoces
pour éviter une issue fatale, un handicap ou une charge financière pour les patients et leurs familles. e. La
maladie affecte également le bien-être de l'homme lorsque le bétail constitue son moyen de subsistance et
un élément important de la pratique agricole. La prévention est un mayen efficace de lutte contre la maladie.
Ces observations fournissent des données sur la survenue des cas d’anthrax dans les communes de Alafia
et Douekiré dans la région de Tombouctou ; les caractéristiques des populations et la description de la zone
en appliquant une approche One Health et la vaccination du cheptel. L’objectif était de Vacciner au moins
80% du cheptel identifié des communes de Alafia dans le cercle de Tombouctou, et de Douekiré dans le
cercle Goundam contre le charbon bactéridien afin de prévenir une épizootie de pathologie infectieuse
zoonotique.
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The article "Under- and over-diagnosis of COPD: a global perspective" reviews the worldwide variation in the prevalence of chronic obstructive pulmonary disease (COPD) and issues related to its misdiagnosis. It highlights that COPD is under-diagnosed due to factors such as limited access to spiromet...ry and variable diagnostic criteria, especially in low- and middle-income countries. Conversely, over-diagnosis often results from reliance on non-standard criteria or inadequate spirometry use. The article discusses key risk factors, including age, gender, exposure to pollutants, and comorbidities, and emphasizes the need for standardized diagnostic practices to better address and manage COPD globally.
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The development of this target product profile (TPP) was led by the WHO Department of Control of Neglected Tropical Diseases (NTD) following standard WHO guidance for TPP development. In order to identify and prioritize diagnostic needs, a WHO NTD Diagnostics Technical Advisory Group (DTAG) was form...ed, and different subgroups were created to advise on specific NTDs, including a subgroup working on the human African trypanosomiasis (HAT) diagnostic innovation needs. This group of independent experts included leading scientists, public health officials and endemic-country end-user representatives. Standard WHO Declaration of Interest procedures were followed. A landscape analysis of the available products and of the development pipeline was conducted, and the salient areas with unmet needs were identified.
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The updates are based on evidence emerging from the: Ongoing monitoring of the disease. Protection that the population already developed against COVID-19 through previous infection or vaccination. Epidemiological situation, availability of diagnostic tests and access to therapeutic options.
Operational Guidelines for the national and district health workers & planners.
These new approaches include use of selective chemotherapy, Rapid Diagnostic Tests (RDTs), Zinc for treatment of cholera in children and complementary use of OCV
The information contained in this document, be it guidelines, recommendations, diagnostic algorithms or treatment regimens, are offered in this document in the public interest. To the best of the knowledge of the guideline writing team, the information contained in these guidelines is correct. Imple...mentation of any aspect of these guidelines remains the responsibility of the implementing agency in so far as public health liability resides, or the responsibility of the individual clinician in the case of diagnosis or treatment.
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Le présent document est un manuel destiné au Dispensateur de Soins à Domicile (DSDOM) exerçant dans un site PECADOM. Il a pour objet de l’aider à prendre en charge de façon précoce et adéquate le paludisme, la diarrhée et les infections respiratoires aigües.
Les informations et les ...images contenues dans le manuel aideront le DSDOM d’une part à se familiariser avec les différentes pathologies décrites pour un diagnostic et un traitement adéquats et d’autre part à connaitre les messages clés à véhiculer sur la prise en charge et la prévention du paludisme, des IRA et de la diarrhée au niveau communautaire.
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La enfermedad de Chagas es parasitaria y afecta a más de 6 millones
de personas en el mundo. Como normalmente es asintomática durante
años, los nuevos casos suelen no detectarse ni reportarse y la mayoría
de las personas con la enfermedad no tiene conciencia de su condición.
Se diagnostica ...a menos del 10% de las personas afectadas, y en su gran
mayoría estas no reciben el tratamiento que necesitan. Sin tratamiento,
la enfermedad de Chagas puede causar daños irreversibles al corazón y
otros órganos vitales, o la muerte.
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The Strategic plan aims to ensure alignment of preparedness and readiness actions in the nine countries focusing on eight technical areas: strengthening multisectoral coordination; surveillance for early detection; laboratory diagnostic capacity; points of entry; rapid response teams; risk communica...tion, social mobilization and community engagement; case management and infection prevention and control (IPC) capacities; and, operations support and logistics. The purpose of the WHO Regional Strategic Plan is to ensure that the countries bordering the Democratic Republic of the Congo are prepared and ready to implement timely and effective risk mitigation, detection and response measures should there be any importation of EVD cases.
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This document provides interim guidance to countries on testing considerations and strategies for suspect cases of severe acute hepatitis of unknown aetiology in children. It is primarily intended for clinical, programmatic, laboratory and diagnostic stakeholders across Member States and national pu...blic health authorities involved in the identification and investigation of cases of severe acute hepatitis in children.
This document is part of a package of guidance for this event, which includes suggested minimum reporting variables and a clinical Case Report Form support Member States with case investigation and reporting.
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