Posttraumatic stress disorder (PTSD) in children and adolescents occurs as a result of a child’s exposure to one or more traumatic events: actual or threatened death, serious injury, or sexual violence. The victim may experience the event, witness it, learn about it from close family members or fr...iends, or experience repeated or extreme exposure to aversive details of the event. Potentially traumatic events include physical or sexual assaults, natural disasters, and accidents.
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The Global Campaign Against Epilepsy “Out of the Shadows”
Global Campaign Against Epilepsy
Version 15.4.2020
Mögliche Szenarien mit unterschiedlicher Daür und Wirkungsstärke wesentlicher Gegenmaßnahmen
Dieser Leitfaden soll ambulant tätige Ärztinnen und Ärzten in der für diese Klärung erforderlichen qualifizierten Gesprächsführung sowie in derkorrespondierenden, krisentauglichen Dokumentation unterstützen. Dazu werden nach einer Vorbemerkung (II.) Hinweise zur Therapiezielklärung (III.), ...zur Einschätzung der Prognose (IV.) und zur Ermittlung des Patientenwillens (V.) gegeben. Eine Priorisierung (Triage) wegen der Knappheit intensivmedizinischer Ressourcen ist Aufgabe der stationären Intensivmedizin und sollte im ambulanten Bereich vermieden werden (VI.)
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ifo Schnelldienst, 2020, 73, Nr. 12, 46-57
Der Artikel zeigt, dass diskriminierende Strukturen und die besondere Schutzbedürftigkeit von geflüchteten Kindern durch das Auftreten von Covid-19 verstärkt werden. Geflüchtete Kinder verfügen über weniger digitale Ausstattung, teilweise werden si...e nicht von der Schulpflicht erfasst, sowohl ehrenamtliche als auch psychosoziale Angebote werden erschwert und die Integration durch „Social Distancing“ beeinträchtigt
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15 July 2021. This report describes the demographics, clinical presentation, clinical outcomes, and risk factors among people living with HIV (PLHIV) who have been hospitalized for suspected or confirmed COVID-19.
The specific objectives of the analysis were to:
describe the clinical char...acteristics and outcomes of PLHIV hospitalized for COVID-19
assess whether PLHIV hospitalized with COVID-19 were at increased risk of presenting with severe or critical illness at admission and were at increased risk of in-hospital death compared to individuals not infected with HIV
assess risk factors associated with severe or critical illness at hospital admission and of in-hospital death among PLHIV hospitalized for COVID-19.
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Each year more than one million women are diagnosed with breast cancer worldwide over half of whom will die from the disease. Breast cancer is the most common cancer and the leading cause of cancer death for women
Chagas disease is a tropical parasitic infection transmitted by crawling, blood-sucking insects (kissing bugs). You may have flu-like symptoms or none at all. But the disease can lead to life-threatening complications. With prompt treatment, most people with Chagas disease, also known as American tr...ypanosomiasis, recover fully.
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Schistosomiasis is a helminthic infection and one of the neglected tropical diseases (NTDs). It is caused by blood flukes of the genus Schistosoma. It is an important public health problem, particularly in poverty-stricken areas, especially those within the tropics and subtropics. It is estimated th...at at least 236 million people worldwide are infected, 90% of them in sub-Saharan Africa, and that this disease causes approximately 300,000 deaths annually. The clinical manifestations are varied and affect practically all organs. There are substantial differences in the clinical presentation, depending on the phase and clinical form of schistosomiasis in which it occurs. Schistosomiasis can remain undiagnosed for a long period of time, with secondary clinical lesion. Here, we review the clinical profile of schistosomiasis. This information may aid in the development of more efficacious treatments and improved disease prognosis.
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Treatment of second-stage gambiense human African trypanosomiasis relied on toxicarsenic-based derivatives for over 50 years. The availability and subsequent use of eflornithine,initially in monotherapy and more recently in combination with nifurtimox (NECT), has drasticallyimproved the pro...gnosis of treated patients. However, NECT logistic and nursing requirementsremain obstacles to its deployment and use in peripheral health structures in rural sub-SaharanAfrica. Two oral compounds, fexinidazole and SCYX-7158, are currently in clinical development.The main scope of this article is to discuss the potential impact of new oral therapies to improvediagnosis-treatment algorithms and patients’access to treatment, and to contribute to reach theobjectives of the recently launched gambiense humanAfrican trypanosomiasis elimination program
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In der Fünften zivilgesellschaftlichen Bestandsaufnahme vom September 2016 mussten wir aufgrund der
damaligen Datenlage auf Projektionen für die Jahre 2014 und 2015 zurückgreifen. Insgesamt kam die
Schätzung der ODA-Zuschüsse für Gesundheit von damals sehr nah an die jetzt genauer bestimmte ...Summe, die
von allen relevanten Geberstaaten ausgezahlt wurde. Allerdings sind einige Korrekturen bei den Leistungen
einzelner Länder festzustellen, die zu bedeutenden Verschiebungen in den Beitragsanteilen führten.
Insbesondere bei Deutschland und einigen anderen europäischen Staaten erwiesen sich die realen
Auszahlungen als erheblich niedriger als zunächst vorhergesagt. Auf der anderen Seite führte die zum ersten
Mal realisierte Analyse der durch die USA unterstützten Projekte zu einem signifikant höheren Ergebnis als die
frühere Schätzung auf Basis der Geberangaben. Zu den wesentlichen Gründen für die Abweichungen zählen der
beschränkte prognostische Wert der angegebenen Neuzusagen für die im folgenden Jahr getätigten
Auszahlungen, der geringere Umfang oder die verzögerte Auszahlung der zusätzlichen Mittel für die
Bekämpfung des Ebola-Ausbruchs in Westafrika sowie die unterschiedliche Praxis der Berichterstattung über
die sektorale Zuordnung der Projekte und Komponenten zwischen den Geberländern.
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Peripheral artery disease (PAD) is the most underdiagnosed, underestimated and undertreated of the atherosclerotic vascular diseases despite its poor prognosis. There may be racial or contextual differences in the Asia-Pacific region as to epidemiology, availability of diagnostic and therapeutic mod...alities, and even patient treatment response. The Asian Pacific Society of Atherosclerosis and Vascular Diseases (APSAVD) thus coordinated the development of an Asia-Pacific Consensus Statement (APCS) on the Management of PAD.
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Background
Chronic congestive heart failure is a common condition that, if untreated, markedly impairs the quality of life and is associated with a high risk of recurrent hospitalization and death.
Methods
This review is based on articles retrieved by a selective search in PubMed, as well as on r...elevant guidelines.
Results
Evidence-based treatment options are available only for congestive heart failure with a low ejection fraction. Pharmacotherapy is based on neurohumoral inhibition of the renin-angiotensin-aldosterone system and the adrenergic system. The prognosis of patients with this condition has been further improved recently through the introduction of combined angiotensin receptor antagonists and neprilysin inhibitors. Modern implantable devices are a further component of treatment. Implantable defibrillators and special pacemakers for cardiac resynchronization are well established; the utility of alternative devices (baroreflex modulation or cardiac contractility modulation) needs to be investigated in further studies. It was recently shown that the catheter-based treatment of secondary mitral regurgitation with a MitraClip improves the outcome of selected patients.
Conclusion
The treatment of chronic systolic heart failure as recommended in the relevant guidelines, with drugs and implanted devices if indicated, can significantly improve the clinical outcome.
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The cardiovascular disease continuum begins with risk factors such as diabetes mellitus (DM), progresses to vasculopathy and myocardial dysfunction, and finally ends with cardiovascular death. Diabetes is associated with a 2- to 4-fold increased risk for heart failure (HF). Moreover, HF patients wit...h DM have a worse prognosis than those without DM. Diabetes can cause myocardial ischemia via micro- and macrovasculopathy and can directly exert deleterious effects on the myocardium. Hyperglycemia, hyperinsulinemia, and insulin resistance can cause alterations in vascular homeostasis. Then, reduced nitric oxide and increased reactive oxygen species levels favor inflammation leading to atherothrombotic progression and myocardial dysfunction. The classification, diagnosis, and treatment of HF for a patient with and without DM remain the same. Until now, drugs targeting neurohumoral and metabolic pathways improved mortality and morbidity in HF with reduced ejection fraction (HFrEF). Therefore, all HFrEF patients should receive guideline-directed medical therapy. By contrast, drugs modulating neurohumoral activity did not improve survival in HF with preserved ejection fraction (HFpEF) patients. Trials investigating whether sodium-glucose cotransporter-2 inhibitors are effective in HFpEF are on-going. This review will summarize the epidemiology, pathophysiology, and treatment of HF in diabetes.
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Ensure treatment decisions are timely, rely on evidence-based guidelines, capture key elements within the social determinants of health, and are made collaboratively with people with diabetes and care partners based on individual preferences, prognoses, comorbidities, and informed financial conside...rations.
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Coronary heart disease (CHD) is the single most common cause of death globally. However, with falling CHD mortality rates, an increasingnumber of people live with CHD and may need support to manage their symptoms and improve prognosis. Cardiac rehabilitation is acomplex multifaceted intervention whi...ch aims to improve the health outcomes of people with CHD. Cardiac rehabilitation consists of threecore modalities: education, exercise training and psychological support. This is an update of a Cochrane systematic review previouslypublished in 2011, which aims to investigate the specific impact of the educational component of cardiac rehabilitation.
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Our awareness necessity of cystic fibrosis (CF) significantly predates our ability to comprehend the molecular factors that underpin its cause and affect prognosis. The dire warning “Woe to that child which when kissed on the forehead tastes salty. He is bewitched and soon must die” has been cir...culating since the 1800s. CF patients taste salty when kissed because an elevated level of sweat chloride is a hallmark of the disease. If untreated, they rarely make it past their first birthday. Typical presentation also includes failure to thrive caused by pancreatic insufficiency and chronic recurrent chest infections.
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The article from the European Respiratory Journal discusses the natural history of chronic obstructive pulmonary disease (COPD), emphasizing its increasing global impact on morbidity and mortality. It highlights that while cigarette smoking is a primary risk factor, other influences such as environm...ental exposures and genetics also play significant roles. The article notes that lung function, measured by FEV1 (forced expiratory volume in one second), is a critical indicator of both diagnosis and prognosis. It further explores the impact of exacerbations, comorbidities, and systemic inflammation on disease progression and outcomes. The need for comprehensive patient management, which considers various comorbid conditions and inflammatory factors, is emphasized to improve clinical outcomes and reduce healthcare costs.
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