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During the COVID-19 pandemic, healthcare providers in areas where dengue is endemic or who are treating patients with recent travel history to these areas, need to consider dengue and COVID-19 in the differential diagnosis of acute febrile illnesses.
Lymphatic filariasis is a neglected tropical disease that can cause permanent disability through disruption of the lymphatic system. This disease is caused by parasitic filarial worms that are transmitted by mosquitos. Mass drug administration (MDA) of antihelmintics is recommended by WHO to elimina
...
te lymphatic filariasis as a public health problem. This study aims to produce the first geospatial estimates of the global prevalence of lymphatic filariasis infection over time, to quantify progress towards elimination, and to identify geographical variation in distribution of infection.
more
The WHF IASC Roadmap proposes strategies and evidence-based solutions for healthcare professionals, health authorities and governments to help overcome the barriers to comprehensive care for Chagas disease patients. This roadmap describes an ideal patient care pathway, and explores the roadblocks al
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ong the way, offering potential solutions based on available research and examples in practice. It represents a call to action to decision-makers and health care professionals to step up efforts to eradicate Chagas disease.
more
J Clin Med . 2020 May 18;9(5):1517. doi: 10.3390/jcm9051517.
Chagas disease (CD) is a major burden in Latin America, expanding also to non-endemic countries. A gold standard to detect the CD causing pathogen Trypanosoma cruzi is currently not available. Existing real time polymerase chain reaction
...
s (RT-PCRs) lack sensitivity and/or specificity. We present a new, highly specific RT-PCR for the diagnosis and monitoring of CD.
more
Trachoma is an eye infection that for thousands of years caused many people to go blind across all continents. As the result of development and targeted interventions, trachoma is now limited to an estimated 57 countries, often affecting the poorest
populations of the world. Today, more than 2 mill
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ion people are either blind or suffer from a very painful disability as the result of trachoma.
more
The boundaries and names shown and the designations used on this map do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities,
or concerning the delimitation of its fr
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ontiers or boundaries. Dotted and dashed lines on maps represent approximate border lines for which there may not yet be full agreement.
more
eLife 2020;9:e52072. The Triatominae are vectors for Trypanosoma cruzi, the aetiological agent of the neglected tropical Chagas disease. Their distribution stretches across Latin America, with some species occurring outside of the Americas. In particular, the cosmopolitan vector, Triatoma rubrofasci
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ata, has already been detected in many Asian and African countries. We applied an ensemble forecasting niche modelling approach to project the climatic suitability of 11 triatomine species under current climate conditions on a global scale. Our results revealed potential hotspots of triatomine species diversity in tropical and subtropical regions between 21 ̊N and 24 ̊S latitude. We also determined the climatic suitability of two temperate species (T. infestans, T. sordida) in Europe, western Australia and New Zealand. Triatoma rubrofasciata has been projected to find climatically suitable conditions in large parts of coastal areas throughout Latin America, Africa and Southeast Asia, emphasising the importance of an international vector surveillance program in these regions.
more
Chagas disease, or American trypanosomiasis, is a condition that causes gradual organ damage. Without treatment, it can be fatal.
This article explains where the T. cruzi parasite is most common and how it can spread. It also outlines the symptoms of Chagas disease and the treatment options avail
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able.
more
PROGRAM DESCRIPTION: Course is designed to increase knowledge and develop competency in the management of patients suspected of infection with dengue virus.
El propósito de este curso es proveer al personal de salud encargado de atender casos sospechosos de dengue la información necesaria para realizar un diagnóstico y manejo clínico oportuno, evitando la progresión a las formas graves y las muertes ocasionadas por esta enfermedad.
Dengue Fever & What You Need to Know, including Pathophysiology, Symptoms, Diagnosis & Treatment. Dengue fever is a viral infection with potentially fatal consequences. In this lesson, we discuss how people are infected with Dengue fever, pathophysiology of the condition, along with phases of infect
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ion, signs and symptoms, diagnosis, treatment, preventative methods (vaccines, mosquito repellent).
more
The protozoan parasite Trypanosoma cruzi causes Chagas disease, an important public health problem throughout Latin America. Current therapeutic options are characterised by limited efficacy, long treatment regimens and frequent toxic side-effects. Advances in this area have been compromised by gaps
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in our knowledge of disease pathogenesis, parasite biology and drug activity. Nevertheless, several factors have come together to create a more optimistic scenario. Drug-based research has become more systematic, with increased collaborations between the academic and commercial sectors, often within the framework of not-for-profit consortia. High-throughput screening of compound libraries is being widely applied, and new technical advances are helping to streamline the drug development pipeline. In addition, drug repurposing and optimisation of current treatment regimens, informed by laboratory research, are providing a basis for new clinical trials. Here, we will provide an overview of the current status of Chagas disease drug development, highlight those areas where progress can be expected, and describe how fundamental research is helping to underpin the process.
more
Infographic
There are currently 4 different serotypes of Dengue virus known to science. Each time someone get infected and recovers, the individual will be protected by a lifelong immunity from further infection against that specific serotype and that serotype only.
Consequent infection from different serotype
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not only will infect the individual but may also cause a more serious or severe disease progression.
more
• تشكّل مقاومة مضادات الميكروبات تهديداً عالمياً للصحة والتنمية، وهي تستدعي اتخاذ إجراءات عاجلة متعددة القطاعات بشأنها من أجل تحقيق أهداف التنمية المستدامة.
أعلن
...
ت المنظمة أن مقاومة مضادات الميكروبات من التهديدات العالمية العشرة الرئيسية للصحة العامة التي تواجه البشرية.
تعدّ إساءة استعمال مضادات الميكروبات والإفراط في استعمالها المحركان الرئيسيان لظهور المُمرضات المقاومة للأدوية.
يؤدي نقص المياه النظيفة وخدمات الإصحاح وقصور الوقاية من عدوى الأمراض ومكافحتها إلى تعزيز انتشار الميكروبات التي يمكن لبعضها أن يقاوم العلاج بمضادات الميكروبات.
يترتب على مقاومة مضادات الميكروبات تكاليف طائلة. وإضافة إلى ما تخلفه الاعتلالات الممتدة لأجل طويل من وفيات وإعاقات، فإنها تسفر عن إطالة أمد رقود المرضى في المستشفيات وحاجتهم إلى أدوية أغلى ومواجهتهم لتحديات مالية.
من شأن نجاح الطب الحديث في حالات العدوى، بوسائل منها العمليات الجراحية الكبرى والعلاج الكيميائي للسرطان، أن يتعرض لمخاطر متزايدة من دون استعمال مضادات ميكروبات ناجعة.
more
Intégré à une équipe, l’aide-soignant assiste l’infirmier dans les activités quotidiennes de soins. Il contribue au bien-être des malades, en les accompagnant dans tous les gestes de la vie quotidienne et en aidant au maintien de leur autonomie.
En collaboration avec l’infirmier et sous
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sa responsabilité, l’aide-soignant assure auprès des patients des soins d’hygiène et de confort : toilette, repas, réfection des lits, accueil, installation et transfert des patients…
more
New Drugs for Human African Trypanosomiasis: A Twenty First Century Success Story
Dickie, E.A.; Giordani, F.; Gould, M.K.; Mäser, P.; Burri, C.; Mottram, J.C.; Rao, S.P.S.; Barrett, M.P.
MDPI Tropical Medicine and Infectious Disease
(2020)
CC2
The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging across many parts of Africa. Resistance to existing drugs was emerging, and many programs aiming to contain the disease had ground to a halt, given previous success against HAT and the competing priorities associat
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ed with other medical crises ravaging the continent. A series of dedicated interventions and the introduction of innovative routes to develop drugs, involving Product Development Partnerships, has led to a dramatic turnaround in the fight against HAT caused by Trypanosoma brucei gambiense. The World Health Organization have been able to optimize the use of existing tools to monitor and intervene in the disease. A promising new oral medication for stage 1 HAT, pafuramidine maleate, ultimately failed due to unforeseen toxicity issues. However, the clinical trials for this compound demonstrated the possibility of conducting such trials in the resource-poor settings of rural Africa.
more
Chagas disease affects approximately 6 million people, mainly in Latin America. Less than 1% of affected individuals receive proper antiparasitic treatment, and current drugs are inadequate to fight the entire spectrum of the disease. Against this background, Novartis is pursuing an end-to-end appro
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ach, with activity on three fronts: drug discovery, clinical research and health system strengthening.
more
Leishmaniasis is a parasitic disease that is found in parts of the tropics, subtropics, and southern Europe. Leishmaniasis is caused by infection with Leishmania parasites, which are spread by the bite of infected sand flies. There are several different forms of leishmaniasis in people. The most com
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mon forms are cutaneous leishmaniasis, which causes skin sores, and visceral leishmaniasis, which affects several internal organs (usually spleen, liver, and bone marrow).
more
Progress Toward Global Eradication of Dracunculiasis
Hopkins, D.; Weiss, A.; Roy, S.
Morbidity and Mortality Weekly Report MMWR; National Libary of Medicine
(2020)
CC
Dracunculiasis (Guinea worm disease), caused by the parasite Dracunculus medinensis, is traditionally acquired by drinking water containing copepods (water fleas) infected with D. medinensis larvae, but in recent years also appears increasingly to be transmitted by eating fish or other aquatic anima
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ls. The worm typically emerges through the skin on a lower limb of the host 1 year after infection, causing pain and disability.
more
