During the year 2022, COVID-19 continued to be a significant challenge in Eritrea as in many other countries across the world. As COVID-19 devastated communities around the world, WHO worked with the MoH to strengthen the National and Sub-National health systems in order to meet community needs and mitigate the devastation during the pandemic and beyond. One of the major achievements in the year 2022 was the beginning of the journey towards validation of the elimination of mother to child transmission of HIV, syphilis, and hepatitis B. This is the culmination of years of commitment and determination by the political leadership, national and international partnerships to reduce the associated indices to levels that qualify for elimination.