In Vietnam, most of the examination and treatment facilities are facing with of spread of bacteria resistant to many antibiotics. The level and speed of drug resistance are increasing, at alarming level. The burden of drug resistance is increasing due to the increasing cost of treatment, prolonged treatment,. That will affect patients’ health, community and social development. In the future, many nations will be able to face the possibility of having no effective drugs to treat infectious diseases if they do not make appropriate interventions.