Tuberculosis (TB) remains a serious public health threat in South Africa and is the leading cause of death in people living with HIV (PWH). Pre-hospital and early in- hospital mortality is of particular concern in PWH. Significant progress has been made to date, but a monumental effort is required to reach the END TB target of zero deaths due to TB by 2035. One of the measures would be to curb early in-hospital mortality due to TB. This goal provided impetus for the development of this package of care.