The WHO Laboratory Biosafety Manual (LBM) has been in broad use at all levels of clinical and public health laboratories, and other biomedical sectors globally, serving as a de facto global standard that presents best practices and sets trends in biosafety. The LBM4 suite consists of one core document and 7 subject-specific monographs which were developed in order to accommodate diverse interests and requests for learning more specific details, supplementing the core document. Readers are encouraged to start with the core document and learn the subject explained in each monograph accordingly.