The key actions, activities, and approaches in this document are organized within each of the 5Cs (see Table 1 in the PDF) and those of the Strategic preparedness and response plan (SPRP) pillars as follows: National action plan key activities, prioritized for the current context and the current understanding of the threat of SARS-CoV-2 A. Transition from emergency response to longer term COVID-19 disease management. B. Integrate activities into routine systems. C. Strengthen global health security. Special considerations for fragile, conflict-affected and vulnerable (including humanitarian) settings WHO global and regional support to Member States to implement their national action plans Key guidance documents for reference This is a living document that will be updated to incorporate new technical guidance in response to the evolving epidemiological situation. National plans should be implemented in accordance with the principles of inclusiveness, respect for human rights, and equity.