The World Health Organization's fourth Country Cooperation Strategy 2022-2026 is an outcome of a consultative process with inputs from the Ministry of Health, various agencies in the health sector, and other relevant stakeholders. It has been developed to provide strategic direction and support toward achieving the priorities of the Government of the Kingdom of Eswatini. It is designed to support the strengthening of health systems and services toward the attainment of Universal Health Coverage (UHC) and the Sustainable Development Goals targets. The CCS 2022-2026 also presents the collaborative agenda between the Kingdom of Eswatini and the three levels of WHO, aligns with the strategic priorities of WHO’s 13th General Programme of Work (2019 – 2025), as well as Eswatini’s United Nations Sustainable Development Cooperation Framework (UNSDCF) 2021-2025