The objective of the EMTCT Plus initiative is to achieve and sustain the elimination of mother-to-child transmission of HIV, syphilis, Chagas, and perinatal hepatitis B (HBV) as a public health threat. It embraces the principles and lines of action of the Strategy for Universal Access to Health and Universal Health Coverage [2], building upon the lessons learned from the PAHO 2010 Strategy and Plan of Action for the EMTCT of HIV and Congenital Syphilis.